scholarly journals Association of endothelial progenitor cells and peptic ulcer treatment in patients with type 2 diabetes mellitus

2016 ◽  
Vol 11 (5) ◽  
pp. 1581-1586
Author(s):  
ZHIHONG NIE ◽  
LIMIN XU ◽  
CHUANYUAN LI ◽  
TAO TIAN ◽  
PINGPING XIE ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peptic Ulcer ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Ulcer Treatment

scholarly journals Oxidant Stress Impairs In Vivo Reendothelialization Capacity of Endothelial Progenitor Cells From Patients With Type 2 Diabetes Mellitus

Circulation ◽  
2007 ◽  
Vol 116 (2) ◽  
pp. 163-173 ◽  
Author(s):  
Sajoscha A. Sorrentino ◽  
Ferdinand H. Bahlmann ◽  
Christian Besler ◽  
Maja Müller ◽  
Svenja Schulz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Oxidant Stress ◽  
Endothelial Progenitor

scholarly journals RELATION OF GROWTH-DIFFERENTIATION FACTOR-15 LEVELS AND NUMBER OF CIRCULATING ENDOTHELIAL PROGENITOR CELLS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2018 ◽  
Vol 2 (2) ◽  
pp. 15-15
Author(s):  
Alexander A. Kremzer ◽  
Ivan M. Fushtey ◽  
Alexander A. Berezin
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Growth Differentiation Factor 15 ◽  
Differentiation Factor ◽  
Circulating Endothelial Progenitor Cells

RELATION OF GROWTH-DIFFERENTIATION FACTOR-15 LEVELS AND NUMBER OF CIRCULATING ENDOTHELIAL PROGENITOR CELLS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

scholarly journals The Number and Potency of Endothelial Progenitor Cells in Type 2 Diabetes Mellitus Patients

2019 ◽  
Vol 11 (2) ◽  
pp. 205-9
Author(s):  
Siska Darmayanti ◽  
Rini Hendriani ◽  
Cynthia Retna Sartika
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Specific Marker ◽  
Endothelial Progenitor ◽  
Hematopoietic Stem

BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is a metabolic disease, due to the disorder of insulin function, insulin secretion, or both. Long-term hyperglycemia conditions promote endothelial dysfunction precedes to the development of multiple organ dysfunctions. Endothelial progenitor cells (EPCs) and hematopoietic stem cell (HSCs) are the key cellular effectors of postnatal neovascularization and play central role in endothelial dysfunction. However, in T2DM condition, the number of apoptotic HSCs increase, it may cause the reduction in potency and number of EPCs. In diabetes, the circulating EPCs number decrease and their functionality is impaired,  but mechanism underlie of this impairement is unknown. The purpose of this study was to examine the relationship duration diabetes with  the number and potency of EPC cells in T2DM patients controlled and poorly controlled.METHODS: Thirty-eight T2DM male patients were classified into two group based on Indonesian Society of Endocrinology/Perkumpulan Endokrinologi Indonesia (PERKENI) criteria   on T2DM.  The   first   group   was a controlled glycemic condition group (hemoglobin A1c (HbA1C) <7.0%) and the second group was a poorly controlled glycemic condition group (HbA1C >7.0%). Cluster of differentiation (CD)34+ and CD133+ expressions were used as specific marker for EPC, while quantified bright aldehyde dehydrogenase (ALDHbr) assay was used to represented the potency of EPCs.RESULTS: This study showed that in poorly controlled T2DM group the number of EPCs was lower by 24.80% (p<0.05) compared to the T2DM controlled group. Similarly, the expression of ALDHbr was lower by 43.07% (p<0.05) in poorly controlled group.CONCLUSION: There was a decrease in the number and potency of EPCs in poorly controlled T2DM patients compared to the controlled T2DM patients. There was also a strong negative correlation between the duration of diabetes and number of EPCs.KEYWORDS: ALDHbr, endothelial progenitor cells, type 2 diabetes mellitus

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