scholarly journals Association between Wnt inhibitory factor-1 expression levels in articular cartilage and the disease severity of patients with osteoarthritis of the knee

2016 ◽  
Vol 11 (4) ◽  
pp. 1405-1409 ◽  
Author(s):  
SHU-GUANG GAO ◽  
CHAO ZENG ◽  
JUN-JIE LIU ◽  
JIAN TIAN ◽  
CHAO CHENG ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Disease Severity ◽  
Inhibitory Factor ◽  
Osteoarthritis Of The Knee ◽  
Expression Levels ◽  
Wnt Inhibitory Factor 1 ◽  
Inhibitory Factor 1

scholarly journals Promoter methylation of WNT inhibitory factor-1 may be associated with the pathogenesis of multiple human tumors

2018 ◽  
Vol 14 (9) ◽  
pp. 381 ◽  
Author(s):  
Jianliang Zhang ◽  
Yong Zhou ◽  
Zhaohua Li ◽  
Yinlu Ding ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Promoter Methylation ◽  
Human Tumors ◽  
Inhibitory Factor ◽  
Wnt Inhibitory Factor 1 ◽  
Inhibitory Factor 1

scholarly journals Evaluating macrophage migration inhibitory factor 1 expression as a prognostic biomarker in colon cancer

Tumor Biology ◽  
2020 ◽  
Vol 42 (6) ◽  
pp. 101042832092452
Author(s):  
Lina Olsson ◽  
Gudrun Lindmark ◽  
Marie-Louise Hammarström ◽  
Sten Hammarström ◽  
Basel Sitohy
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Mrna Expression ◽  
Cancer Patients ◽  
Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Expression Levels ◽  
Significant Difference ◽  
Mrna Expression Levels ◽  
Inhibitory Factor 1

Objective: Several studies indicate that macrophage migration inhibitory factor 1 plays a role for tumor progression in colon cancer. We investigated whether determination of migration inhibitory factor 1 mRNA expression levels in lymph nodes of colon cancer patients could be used as a prognostic marker. Methods: Expression levels of migration inhibitory factor 1 and carcinoembryonic antigen mRNAs were assessed in primary tumors and regional lymph nodes of 123 colon cancer patients (stages I–IV), and in colon cancer- and immune cell lines using quantitative reverse transcriptase–polymerase chain reaction. Expression of migration inhibitory factor 1 protein was investigated by two-color immunohistochemistry and immunomorphometry. Results: Migration inhibitory factor 1 mRNA was expressed at 60 times higher levels in primary colon cancer tumors compared to normal colonic tissue (medians 8.2 and 0.2 mRNA copies/18S rRNA unit; p < .0001). A highly significant difference in mRNA expression levels was found between hematoxylin-eosin positive lymph nodes and hematoxylin-eosin negative lymph nodes (p < .0001). Migration inhibitory factor 1 and carcinoembryonic antigen proteins were simultaneously expressed in many colon cancer-tumor cells. Kaplan–Meier survival model and hazard ratio analysis, using a cutoff level at 2.19 mRNA copies/18S rRNA unit, revealed that patients with lymph nodes expressing high levels of migration inhibitory factor 1 mRNA had a 3.5-fold (p = .04) higher risk for recurrence, associated with a small, but significant, difference in mean survival time (7 months, p = .03) at 12 years of follow-up. Conclusion: Although migration inhibitory factor 1 mRNA expression levels were related to severity of disease and lymph node analysis revealed that colon cancer patients with high levels had a shorter survival time after surgery than those with low levels, the difference was small and probably not useful in clinical practice.

144 HYPERMETHYLATION SILENCES WNT INHIBITORY FACTOR 1 IN NASOPHARYNGEAL CARCINOMA.

2006 ◽  
Vol 54 (1) ◽  
pp. S104.6-S105
Author(s):  
E. G. Thung ◽  
J. Chou ◽  
L. You ◽  
Z. Xu ◽  
D. M. Jablons
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Inhibitory Factor ◽  
Wnt Inhibitory Factor 1 ◽  
Inhibitory Factor 1

scholarly journals Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers

Oncogene ◽  
2005 ◽  
Vol 24 (53) ◽  
pp. 7946-7952 ◽  
Author(s):  
Hiroaki Taniguchi ◽  
Hiroyuki Yamamoto ◽  
Tamaki Hirata ◽  
Nobuki Miyamoto ◽  
Mariko Oki ◽  
...  
Keyword(s):  
Inhibitory Factor ◽  
Gastrointestinal Cancers ◽  
Epigenetic Inactivation ◽  
Wnt Inhibitory Factor 1 ◽  
Inhibitory Factor 1

scholarly journals Functional Significance of Wnt Inhibitory Factor-1 Gene in Kidney Cancer

2009 ◽  
Vol 69 (22) ◽  
pp. 8603-8610 ◽  
Author(s):  
K. Kawakami ◽  
H. Hirata ◽  
S. Yamamura ◽  
N. Kikuno ◽  
S. Saini ◽  
...  
Keyword(s):  
Kidney Cancer ◽  
Functional Significance ◽  
Inhibitory Factor ◽  
Wnt Inhibitory Factor 1 ◽  
Inhibitory Factor 1

scholarly journals Wnt Inhibitory Factor 1 (Wif1) Is Regulated by Androgens and Enhances Androgen-Dependent Prostate Development

Endocrinology ◽  
2012 ◽  
Vol 153 (12) ◽  
pp. 6091-6103 ◽  
Author(s):  
Kimberly P. Keil ◽  
Vatsal Mehta ◽  
Amanda M. Branam ◽  
Lisa L. Abler ◽  
Rita A. Buresh-Stiemke ◽  
...  
Keyword(s):  
Branching Morphogenesis ◽  
Inhibitory Factor ◽  
Urogenital Sinus ◽  
Sexually Dimorphic ◽  
Bud Formation ◽  
Prostate Development ◽  
Mouse Prostate ◽  
Necessary And Sufficient ◽  
Wnt Inhibitory Factor 1 ◽  
Inhibitory Factor 1

Abstract Fetal prostate development from urogenital sinus (UGS) epithelium requires androgen receptor (AR) activation in UGS mesenchyme (UGM). Despite growing awareness of sexually dimorphic gene expression in the UGS, we are still limited in our knowledge of androgen-responsive genes in UGM that initiate prostate ductal development. We found that WNT inhibitory factor 1 (Wif1) mRNA is more abundant in male vs. female mouse UGM in which its expression temporally and spatially overlaps androgen-responsive steroid 5α-reductase 2 (Srd5a2). Wif1 mRNA is also present in prostatic buds during their elongation and branching morphogenesis. Androgens are necessary and sufficient for Wif1 expression in mouse UGS explant mesenchyme, and testicular androgens remain necessary for normal Wif1 expression in adult mouse prostate stroma. WIF1 contributes functionally to prostatic bud formation. In the presence of androgens, exogenous WIF1 protein increases prostatic bud number and UGS basal epithelial cell proliferation without noticeably altering the pattern of WNT/β-catenin-responsive Axin2 or lymphoid enhancer binding factor 1 (Lef1) mRNA. Wif1 mutant male UGSs exhibit increased (Sfrp)2 and (Sfrp)3 expression and form the same number of prostatic buds as the wild-type control males. Collectively our results reveal Wif1 as one of the few known androgen-responsive genes in the fetal mouse UGM and support the hypothesis that androgen-dependent Wif1 expression is linked to the mechanism of androgen-induced prostatic bud formation.

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