scholarly journals siRNA-mediated downregulation of GluN2B in the rostral anterior cingulate cortex attenuates mechanical allodynia and thermal hyperalgesia in a rat model of pain associated with bone cancer

2015 ◽  
Vol 11 (1) ◽  
pp. 221-229 ◽  
Author(s):  
YONGGUANG XU ◽  
GONGMING WANG ◽  
XULI ZOU ◽  
ZAIQI YANG ◽  
QIN WANG ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Rat Model ◽  
Mechanical Allodynia ◽  
Thermal Hyperalgesia ◽  
Bone Cancer ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Rostral Anterior Cingulate Cortex

scholarly journals Electroacupuncture Alleviates Chronic Pain-Induced Anxiety Disorders by Regulating the rACC-Thalamus Circuitry

2021 ◽  
Vol 14 ◽  
Author(s):  
Zui Shen ◽  
Haiyan Zhang ◽  
Zemin Wu ◽  
Qiaoying He ◽  
Jinggen Liu ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Anxiety Disorders ◽  
Anterior Cingulate Cortex ◽  
Rat Model ◽  
Cingulate Cortex ◽  
Mechanistic Explanation ◽  
Anterior Cingulate ◽  
Intraplantar Injection ◽  
Rostral Anterior Cingulate Cortex ◽  
Underlying Mechanisms

Anxiety is a common comorbidity associated with chronic pain, which results in chronic pain complexification and difficulty in treatment. Electroacupuncture (EA) is commonly used to treat chronic pain and anxiety. However, the underlying mechanisms of the EA effect are largely unknown. Here, we showed that a circuitry underlying chronic pain induces anxiety disorders, and EA can treat them by regulating such circuitry. Using chemogenetic methods, we found that chemogenetic activation of the rostral anterior cingulate cortex (rACC) glutamatergic output to the thalamus induced anxiety disorders in control rats. Then, chemogenetic inhibition of the rACC-thalamus circuitry reduced anxiety-like behavior produced by intraplantar injection of the complete Freund’s adjuvant (CFA). In this study, we examined the effects of EA on a rat model of CFA-mediated anxiety-like behaviors and the related mechanisms. We found that chemogenetic activation of the rACC-thalamus circuitry effectively blocked the effects of EA on chronic pain-induced anxiety-like behaviors in CFA rats. These results demonstrate an underlying rACC-thalamus glutamatergic circuitry that regulates CFA-mediated anxiety-like behaviors. This study also provides a potential mechanistic explanation for EA treatment of anxiety caused by chronic pain.

scholarly journals A connectional hub in the rostral anterior cingulate cortex links areas of emotion and cognitive control

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Wei Tang ◽  
Saad Jbabdi ◽  
Ziyi Zhu ◽  
Michiel Cottaar ◽  
Giorgia Grisot ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Diffusion Magnetic Resonance Imaging ◽  
Cingulate Cortex ◽  
Retrograde Tracing ◽  
Anterior Cingulate ◽  
Resonance Imaging ◽  
Macaque Monkeys ◽  
Afferent Inputs ◽  
Rostral Anterior Cingulate Cortex ◽  
A Site

We investigated afferent inputs from all areas in the frontal cortex (FC) to different subregions in the rostral anterior cingulate cortex (rACC). Using retrograde tracing in macaque monkeys, we quantified projection strength by counting retrogradely labeled cells in each FC area. The projection from different FC regions varied across injection sites in strength, following different spatial patterns. Importantly, a site at the rostral end of the cingulate sulcus stood out as having strong inputs from many areas in diverse FC regions. Moreover, it was at the integrative conjunction of three projection trends across sites. This site marks a connectional hub inside the rACC that integrates FC inputs across functional modalities. Tractography with monkey diffusion magnetic resonance imaging (dMRI) located a similar hub region comparable to the tracing result. Applying the same tractography method to human dMRI data, we demonstrated that a similar hub can be located in the human rACC.

FKBP5 methylation predicts functional network architecture of the rostral anterior cingulate cortex

2019 ◽  
Vol 225 (1) ◽  
pp. 33-43
Author(s):  
Markus Muehlhan ◽  
Robert Miller ◽  
Jens Strehle ◽  
Michael N. Smolka ◽  
Nina Alexander
Keyword(s):  
Anterior Cingulate Cortex ◽  
Network Architecture ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Functional Network ◽  
Rostral Anterior Cingulate Cortex
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