scholarly journals Adenosine monophosphate-activated protein kinase activation mediates the leptin-induced attenuation of cognitive impairment in a streptozotocin-induced rat model

2015 ◽  
Vol 9 (5) ◽  
pp. 1998-2002
Author(s):  
BIN ZHU ◽  
RI-YUE JIANG ◽  
CHUN YANG ◽  
NING LIU
Keyword(s):  
Cognitive Impairment ◽  
Protein Kinase ◽  
Rat Model ◽  
Adenosine Monophosphate ◽  
Kinase Activation ◽  
Protein Kinase Activation

scholarly journals Adenosine monophosphate-activated protein kinase activation protects against sepsis-induced organ injury and inflammation

2015 ◽  
Vol 194 (1) ◽  
pp. 262-272 ◽  
Author(s):  
Daniel A. Escobar ◽  
Ana M. Botero-Quintero ◽  
Benjamin C. Kautza ◽  
Jason Luciano ◽  
Patricia Loughran ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Adenosine Monophosphate ◽  
Organ Injury ◽  
Kinase Activation ◽  
Protein Kinase Activation

Cyclic AMP in action of antidiuretic hormone: effects of exogenous cyclic AMP and its new analogue

1977 ◽  
Vol 232 (4) ◽  
pp. F368-F376 ◽  
Author(s):  
D. A. Hall ◽  
L. D. Barnes ◽  
T. P. Dousa
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Antidiuretic Hormone ◽  
Kidney Tissue ◽  
Adenosine Monophosphate ◽  
Kinase Activation ◽  
Camp Generation ◽  
Protein Kinase Activation ◽  
Hormone Effects ◽  
Collecting Tubules

Exogenous cyclic 3',5'-adenosine monophosphate (cAMP) stimulates the effect of the antidiuretic hormone, vasopressin (VP), only in pharmacologic quantities and results have often been inconsistent. The present study examined the ability of a new analogue, 8-[p-Cl-phenylthio]cyclic 3',5'-adenosine monophosphate (C1-PheS-cAMP) to mimic the effect of VP, both biochemically (protein kinase activation) and functionally (hydrosomatic response of perfused collecting tubules) in mammalian kidney tissue. C1PheS-cAMP was found to be about 100 times as effective as cAMP both biochemically and functionally. The increased effectiveness of C1PheS-cAMP is probably is probably due to a greater permeability across the cell membrane and to the resistance of C1PheS-cAMP to enzymatic degradation, Cyclic AMP phosphodiesterase inhibition was observed with C1PheS-cAMP, but its contribution to overall effect was minor. C1PheS-cAMP was found to be more effective than exogenous vasopressin, an effect probably due primarily to its resistance to catabolism. The results provide further new evidence that cAMP and protein kinase are involved in the cellular action of vasopressin. C1PheS-cAMP proved to be a useful tool in the study of hormone action, especially in steps subsequent to cAMP generation.

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