scholarly journals Expression of human DNA mismatch-repair protein, hMSH2, in patients with oral lichen planus

2014 ◽  
Vol 9 (1) ◽  
pp. 203-206
Author(s):  
HAO-BO LI ◽  
YING-HUAI ZHANG ◽  
HUI-ZHEN CHEN ◽  
YONG CHEN
Keyword(s):  
Mismatch Repair ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Dna Mismatch Repair ◽  
Dna Mismatch ◽  
Human Dna ◽  
Repair Protein ◽  
Oral Lichen ◽  
Mismatch Repair Protein

scholarly journals Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)

2007 ◽  
Vol 35 (8) ◽  
pp. 2609-2619 ◽  
Author(s):  
Nina Østergaard Knudsen ◽  
Finn Cilius Nielsen ◽  
Lena Vinther ◽  
Ronni Bertelsen ◽  
Steen Holten-Andersen ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Nuclear Localization ◽  
Dna Mismatch Repair ◽  
Dna Mismatch ◽  
Human Dna ◽  
Repair Protein ◽  
Exonuclease 1 ◽  
Mismatch Repair Protein

scholarly journals The Bloom's Syndrome Helicase Interacts Directly with the Human DNA Mismatch Repair Protein hMSH6

2003 ◽  
Vol 384 (8) ◽  
Author(s):  
G. Pedrazzi ◽  
C. Z. Bachrati ◽  
N. Selak ◽  
I. Studer ◽  
M. Petkovic ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Bloom's Syndrome ◽  
Dna Mismatch ◽  
Human Dna ◽  
Repair Protein ◽  
Bloom’S Syndrome ◽  
Mismatch Repair Protein

scholarly journals The Human DNA Mismatch Repair Protein MSH3 Contains Nuclear Localization and Export Signals That Enable Nuclear-Cytosolic Shuttling in Response to Inflammation

2020 ◽  
Vol 40 (13) ◽  
Author(s):  
Stephanie S. Tseng-Rogenski ◽  
Koji Munakata ◽  
Daniel Y. Choi ◽  
Paul K. Martin ◽  
Supal Mehta ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Nuclear Localization ◽  
Nuclear Export ◽  
Dna Mismatch Repair ◽  
Dna Mismatch ◽  
Neoplastic Processes ◽  
Human Dna ◽  
Repair Protein ◽  
Exon 1 ◽  
Mismatch Repair Protein

ABSTRACT Inactivation of DNA mismatch repair propels colorectal cancer (CRC) tumorigenesis. CRCs exhibiting elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) show reduced nuclear MutS homolog 3 (MSH3) expression with surrounding inflammation and portend poor patient outcomes. MSH3 reversibly exits from the nucleus to the cytosol in response to the proinflammatory cytokine interleukin-6 (IL-6), suggesting that MSH3 may be a shuttling protein. In this study, we manipulated three putative nuclear localization (NLS1 to -3) and two potential nuclear export signals (NES1 and -2) within MSH3. We found that both NLS1 and NLS2 possess nuclear import function, with NLS1 responsible for nuclear localization within full-length MSH3. We also found that NES1 and NES2 work synergistically to maximize nuclear export, with both being required for IL-6-induced MSH3 export. We examined a 27-bp deletion (Δ27bp) within the polymorphic exon 1 that occurs frequently in human CRC cells and neighbors NLS1. With oxidative stress, MSH3 with this deletion (Δ27bp MSH3) localizes to the cytoplasm, suggesting that NLS1 function in Δ27bp MSH3 is compromised. Overall, MSH3’s shuttling in response to inflammation enables accumulation in the cytoplasm; reduced nuclear MSH3 increases EMAST and DNA damage. We suggest that polymorphic sequences adjacent to NLS1 may enhance cytosolic retention, which has clinical implications for inflammation-associated neoplastic processes.

scholarly journals DNA Mismatch Repair Protein Msh6 Is Required for Optimal Levels of Ultraviolet-B-Induced Apoptosis in Primary Mouse Fibroblasts

2003 ◽  
Vol 121 (4) ◽  
pp. 876-880 ◽  
Author(s):  
Leah C. Young ◽  
Anthea C. Peters ◽  
Tomoko Maeda ◽  
Winfried Edelmann ◽  
Raju Kucherlapati ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Ultraviolet B ◽  
Mouse Fibroblasts ◽  
Dna Mismatch ◽  
Repair Protein ◽  
Primary Mouse ◽  
Induced Apoptosis ◽  
Mismatch Repair Protein

scholarly journals Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis

2008 ◽  
Vol 29 (6) ◽  
pp. 1290-1297 ◽  
Author(s):  
Ruben van Boxtel ◽  
Pim W. Toonen ◽  
Henk S. van Roekel ◽  
Mark Verheul ◽  
Bart M. G. Smits ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Dna Mismatch ◽  
Repair Protein ◽  
Mismatch Repair Protein
Sign in / Sign up

Export Citation Format

Share Document