scholarly journals PAR-2, IL-4R, TGF-β and TNF-α in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis

2014 ◽  
Vol 8 (2) ◽  
pp. 533-538 ◽  
Author(s):  
RADOSLAV MATĚJ ◽  
MAGDALENA SMĚTÁKOVÁ ◽  
MARTINA VAŠÁKOVÁ ◽  
JANA NOVÁKOVÁ ◽  
MARTINA ŠTERCLOVÁ ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Extrinsic Allergic Alveolitis ◽  
Allergic Alveolitis ◽  
Tnf Α

scholarly journals Bronchoalveolar lavage cell profiles and proteins concentrations can be used to phenotype extrinsic allergic alveolitis patients

2019 ◽  
Vol 14 ◽  
Author(s):  
Martina Sterclova ◽  
Magdalena Smetakova ◽  
Ludek Stehlik ◽  
Jelena Skibova ◽  
Martina Vasakova
Keyword(s):  
Bronchoalveolar Lavage ◽  
Negative Correlation ◽  
Corticosteroid Treatment ◽  
Outcome Data ◽  
Extrinsic Allergic Alveolitis ◽  
Allergic Alveolitis ◽  
Tnf Α ◽  
Lung Functions ◽  
Cell Profile

Background: Extrinsic allergic alveolitis (EAA) patients form heterogenous group with different clinical manifestation and different prognosis. We aimed to determine how to phenotype distinct EAA subgroups. Predictive role of the bronchoalveolar lavage fluid (BALF) IL-4Rα concentration at the time of diagnosis with regard to the clinical behavior in EAA patients was studied. Methods: Concentrations of MMP-7, IL-4Rα, TNF-α, and PAR-2 were measured in the BALF od 71 EAA patients at the time of diagnosis. Lung functions and outcome data were assessed at 12 months after the diagnosis. Correlations between the BALF protein concentration, cell profile, lung functions and patient outcome were determined. Results: We found positive correlations between BALF IL-4Rα concentration and BALF eosinophils (p = 0,006), negative correlation between IL-4Rα BALF concentration and diffusing capacity (DLco) (p = 0,003), negative correlation between IL-4Rα BALF concentration and forced vital capacity (FVC) (p = 0,004) and negative correlation between IL-4Rα concentration and BALF lymphocytes (p = 0,04). The BALF concentration of IL-4Rα was significantly higher in acute exacerbation patients (p = 0,0032) and in patients progressing despite corticosteroid treatment (p = 0,04). We observed a positive correlation between MMP-7 BALF concentration and the BALF lymphocytes (p = 0.05), negative correlation between the PAR-2 BALF concentration and DLco (p = 0.04) and a negative correlation between the BALF TNF-α concentration and DLco (p = 0.03). Conclusions: Specific subgroup of EAA patients with more severe functional impact, distinct BALF cell profile and higher IL-4Rα BALF concentration can be differentiated. Correlations between the BALF concentrations of PAR-2, MMP-7 and TNF-α with clinical parameters may reflect the role of inflammation in the pathogenesis of EAA.

Bronchoalveolar Lavage in Extrinsic Allergic Alveolitis

Respiration ◽  
1986 ◽  
Vol 49 (1) ◽  
pp. 45-51 ◽  
Author(s):  
J.M.M. van den Bosch ◽  
C. Heye ◽  
Sj.Sc. Wagenaar ◽  
H.C.W. van Velzen-Blad
Keyword(s):  
Bronchoalveolar Lavage ◽  
Extrinsic Allergic Alveolitis ◽  
Allergic Alveolitis

scholarly journals Transfer of 99mTc DTPA and bronchoalveolar lavage findings in patients with asymptomatic extrinsic allergic alveolitis.

Thorax ◽  
1990 ◽  
Vol 45 (7) ◽  
pp. 525-529 ◽  
Author(s):  
B Schmekel ◽  
P Wollmer ◽  
P Venge ◽  
M Linden ◽  
B Blom-Bulow
Keyword(s):  
Bronchoalveolar Lavage ◽  
Extrinsic Allergic Alveolitis ◽  
Allergic Alveolitis

Hypersensitivity Pneumonitis

Asthma ◽  
2014 ◽  
pp. 3-11
Author(s):  
David I. Bernstein
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Gas Exchange ◽  
Early Diagnosis ◽  
Bronchoalveolar Lavage ◽  
Hypersensitivity Pneumonitis ◽  
Extrinsic Allergic Alveolitis ◽  
Allergic Alveolitis ◽  
High Resolution Computed Tomography ◽  
Parenchymal Lung Disease

Hypersensitivity pneumonitis (HP), also referred to as extrinsic allergic alveolitis, is an allergic inflammatory parenchymal lung disease usually caused by inhalational exposure to organic antigens from microbial bioaerosols or animal sources encountered in the work or home environment. Patients with HP can present with wheezing and obstructive abnormalities leading to an incorrect asthma diagnosis. The presence of a gas exchange abnormality, bronchoalveolar lavage lymphocytosis, and characteristic infiltrative changes on high-resolution computed tomography of the chest can be used to distinguish HP from asthma. The early diagnosis of HP and cessation of exposure to causative antigens result in remission of the disease and no residual impairment.

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