scholarly journals Organ microenvironment affects growth and metastasis of hepatocellular carcinoma via the TGF-β/Smad pathway in mice

2012 ◽  
Vol 5 (1) ◽  
pp. 133-137 ◽  
Author(s):  
GUOCAI LI ◽  
LUNXIU QIN ◽  
QINGHAI YE ◽  
QIONGZHU DONG ◽  
NING REN ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Smad Pathway ◽  
Organ Microenvironment

Asiatic Acid Encapsulated Exosomes of Hepatocellular Carcinoma Inhibit Epithelial-Mesenchymal Transition Through Transforming Growth Factor Beta/Smad Signaling Pathway

2021 ◽  
Vol 17 (12) ◽  
pp. 2338-2350
Author(s):  
Tianming Chen ◽  
Changhao Zhu ◽  
Xing Wang ◽  
Yaozhen Pan ◽  
Bin Huang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Epithelial Mesenchymal Transition ◽  
Asiatic Acid ◽  
Potential Drug ◽  
Smad Pathway ◽  
Mesenchymal Transition ◽  
Cell Vitality ◽  
Liver Cancers ◽  
Hcc Cells

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death in many countries, which accounts for more than 80% of primary liver cancers. Better understanding of the biology of HCC and more therapeutic strategies are urgently needed to improve the current situation. Exosomes, lipid-bound particles derived from cells, have been revealed to play versatile roles in mediating communication between tumor and its microenvironment. Thus, exosomes could act as potential drug delivery systems in cancer treatment. This study aimed to investigate the effect of asiatic acid (AA)-loaded exosomes on the proliferation and migration of HCC cells and clarify the underlying mechanisms. HCC cells were treated with AA-loaded exosomes and cell vitality, migration and invasion were examined. Compared with free AA, AA-loaded exosomes significantly reduced cell vitality, migration, invasion and epithelial mesenchymal transition (EMT). And the inhibition was enhanced as AA concentration went up. Moreover, the expression of proteins involved in EMT and TGF-β/Smad pathway such as TGF-β1, Smad4 and Vimentin were decreased while E-cadherin was up-regulated. Collectively, these findings demonstrate that HCC derived exosomes display as potential drug delivery vehicles in HCC treatment. And AA-loaded exosomes might work by inhibiting EMT through inactivating TGF-β/Smad pathway.

Tumor derived exsomes mediate tumor infiltrating NK-cell dysfunction in patients with hepatocellular carcinoma via TGF-β/SMAD pathway

2017 ◽  
Vol 66 (1) ◽  
pp. S77 ◽  
Author(s):  
Q.-F. Zhang ◽  
W.-W. Yin ◽  
Q. Liu ◽  
Y.-L. Li ◽  
M.-H. Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nk Cell ◽  
Smad Pathway ◽  
Cell Dysfunction

Multimodality treatment of hepatocellular carcinoma

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S315-S319 ◽  
Author(s):  
ZHAO-YOU TANG ◽  
XIN-DA ZHOU ◽  
ZENG-CHEN MA ◽  
ZHI-QUAN WU ◽  
JIA FAN ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Multimodality Treatment

Hepatocellular carcinoma

1982 ◽  
Vol 118 (1) ◽  
pp. 69-70 ◽  
Author(s):  
A. J. Bennett
Keyword(s):  
Hepatocellular Carcinoma

Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplanation

2001 ◽  
Vol 120 (5) ◽  
pp. A90-A90
Author(s):  
N ESNAOLA ◽  
G LAUWERS ◽  
N MIRZA ◽  
D NAGORNEY ◽  
D DOHERTY ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microvascular Invasion

Serum and tissue PIVKA-II expression reflect the biological malignant potential of small hepatocellular carcinoma

2001 ◽  
Vol 120 (5) ◽  
pp. A558-A558
Author(s):  
M TAMANO ◽  
K KOJIMA ◽  
M OGUMA ◽  
M LIJIMA ◽  
T MUROHISA ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Malignant Potential ◽  
Small Hepatocellular Carcinoma
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