scholarly journals Promoter and histone methylation and p16INK4A gene expression in colon cancer

2012 ◽  
Vol 4 (5) ◽  
pp. 865-870 ◽  
Author(s):  
EBRU ESIN YORUKER ◽  
UFUK MERT ◽  
DURSUN BUGRA ◽  
SUMER YAMANER ◽  
NEJAT DALAY
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Histone Methylation ◽  
P16ink4a Gene

scholarly journals Methyltransferases in the Pathogenesis of Keratinocyte Cancers

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3402
Author(s):  
Eun Kyung Ko ◽  
Brian C. Capell
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Histone Methylation ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Therapeutic Approaches ◽  
Novel Therapeutic

Recent evidence suggests that the disruption of gene expression by alterations in DNA, RNA, and histone methylation may be critical contributors to the pathogenesis of keratinocyte cancers (KCs), made up of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), which collectively outnumber all other human cancers combined. While it is clear that methylation modifiers are frequently dysregulated in KCs, the underlying molecular and mechanistic changes are only beginning to be understood. Intriguingly, it has recently emerged that there is extensive cross-talk amongst these distinct methylation processes. Here, we summarize and synthesize the latest findings in this space and highlight how these discoveries may uncover novel therapeutic approaches for these ubiquitous cancers.

scholarly journals Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression

2009 ◽  
Vol 23 (8) ◽  
pp. 951-962 ◽  
Author(s):  
D. P. Mersman ◽  
H.-N. Du ◽  
I. M. Fingerman ◽  
P. F. South ◽  
S. D. Briggs
Keyword(s):  
Gene Expression ◽  
Histone Methylation

Abstract 190: Epigenetic Modifications of Pro-inflammatory Gene Expression in Macrophages by a Demethylase Enzyme, JMJD3, May Promote Chronic Inflammation in Type 2 Diabetic (T2D) Wounds

2013 ◽  
Vol 33 (suppl_1) ◽  
Author(s):  
Katherine A Gallagher ◽  
Amrita Joshi ◽  
William Carson ◽  
Dawn Coleman ◽  
Peter Henke ◽  
...  
Keyword(s):  
Gene Expression ◽  
Progenitor Cells ◽  
Chronic Inflammation ◽  
Histone Methylation ◽  
Gene Promoter ◽  
Epigenetic Modifications ◽  
Macrophage Phenotype ◽  
M1 Macrophage ◽  
Type 2 Diabetic

Introduction Type 2 diabetic(T2D) wounds are characterized by chronic inflammation, maintained by an exaggerated M1(pro-inflammatory) macrophage phenotype response. We seek to define a link between epigenetic modifications of bone marrow(BM) cells in T2D and dysregulated macrophages in wounds. We hypothesized that a chromatin modifying demethylase enzyme, JMJD3, is responsible for the decrease in H3K27me3 repressive methylation at the IL-12 gene promoter and thus drives an M1 macrophage phenotype in T2D wounds. Methods BM/adipose tissue(AT)/wounds were harvested from 30 diet-induced obese mice(DIO)(MG= 350g/DL) and 30 matched(WT) controls. For chromatin immunoprecipitation(ChIP) analysis, cells were isolated via ferromagnetic columns(CD34+,CD11b+). ChIP to detect histone methylation at the promoter regions of JMJD3 and IL-12(key M1 macrophage gene) was performed and RNA analysis was done with standard primers. Results JMJD3 mRNA in the BM is significantly increased in the DIO versus WT. ChIP showed increased H3K4me3(gene expression mark) in CD34+ progenitor cells and a corresponding decrease in H3K27me3(repressive mark) in monocytes at the promoter region of JMJD3. These changes correspond with the decrease in H3K27me3 seen at the IL-12 promoter in macrophages(CD11b+) from AT/T2D wounds. Conclusions Epigenetic changes initiated by JMJD3 in BM progenitor cells result in changes in histone methylation at the IL-12 promoter favoring an M1 phenotype in macrophages and thus contributes to the chronic inflammation seen in T2D wounds and AT. Whether manipulation of epigenetic enzymes could reduce chronic inflammation in T2D wounds requires further work.

scholarly journals The clinical impact of miRNA34a and P53 gene expression in colon cancer

2018 ◽  
Vol 16 ◽  
pp. 88-95 ◽  
Author(s):  
Eman A.E. Badr ◽  
Mohamed Farag Ali Assar ◽  
Suzy F. Gohar ◽  
Mohamed Hamdy Badr ◽  
Rawda Magdy Hathout ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
P53 Gene ◽  
Clinical Impact

Su1772 - The RNA Binding Protein Imp1 Enhances Colon Cancer Metastasis via Promotion of a Pro-Metastatic Gene Expression Program

2018 ◽  
Vol 154 (6) ◽  
pp. S-585
Author(s):  
Sarah F. Andres ◽  
Kathy N. Williams ◽  
Kathryn E. Hamilton ◽  
Rei Mizuno ◽  
Jeff Headd ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cancer Metastasis ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Gene Expression Program ◽  
Colon Cancer Metastasis ◽  
Expression Program

DNA and Histone Methylation in Colon Cancer

2017 ◽  
pp. 461-487
Author(s):  
Hiromu Suzuki ◽  
Eiichiro Yamamoto ◽  
Hiroshi Nakase ◽  
Tamotsu Sugai
Keyword(s):  
Colon Cancer ◽  
Histone Methylation

scholarly journals Colon Cancer and SARS-CoV-2: Impact of ACE2 Expression in Susceptibility to COVID-19

2020 ◽  
Author(s):  
Mohsen Ahmadi ◽  
Negin Saffarzadeh ◽  
Mohammad Amin Habibi ◽  
Fatemeh Hajiesmaeili ◽  
Nima Rezaei
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Immune Cell ◽  
Expression Patterns ◽  
Methylation Status ◽  
Functional Enrichment ◽  
Cell Infiltration ◽  
Survival Outcomes ◽  
Immune Cell Infiltration ◽  
Ace2 Gene

AbstractNovel coronavirus disease (COVID-19) pandemic has become a global health emergency. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts with angiotensin-converting enzyme 2 (ACE2) to enter the cells and infects diverse human tissues. It has been reported that a few conditions, including cancer, predispose individuals to SARS-CoV-2 infection and severe form of COVID-19. These findings led us to evaluate the susceptibility of colon adenocarcinoma (COAD) patients to SARS-CoV-2 infection by investigation of ACE2 expression in their tumor tissues. The expression analysis revealed that both mRNA and protein levels of ACE2 had increased in colon cancer samples than normal group. Next, the prognosis analysis has indicated that the upregulation of ACE2 was not correlated with patient survival outcomes. Further assessment displayed the hypomethylation of the ACE2 gene promoter in COAD patients. Surprisingly, this methylation status has a strong negative correlation with ACE2 gene expression. The functional enrichment analysis of the genes that had similar expression patterns with ACE2 in colon cancer tissues demonstrated that they mainly enriched in Vitamin digestion and absorption, Sulfur relay system, and Fat digestion and absorption pathways. Finally, we found that ACE2 gene expression had a significant association with the immune cell infiltration levels in COAD patients. In conclusion, it has plausible that COAD patients are more likely to be infected with SARS-CoV-2 and experience severe injuries. Moreover, COVID-19 would bring unfavorable survival outcomes of patients with colon cancer by the way of immune cell infiltration linked process. The present study highlights the importance of preventive actions for COAD patients during the COVID-19 pandemic.

Evaluation of the Effects of the Flavonoid Apigenin on Apoptotic Pathway Gene Expression on the Colon Cancer Cell Line (HT29)

2011 ◽  
Vol 14 (10) ◽  
pp. 1107-1117 ◽  
Author(s):  
Mehmet Turktekin ◽  
Ece Konac ◽  
H. Ilke Onen ◽  
Ebru Alp ◽  
Akin Yilmaz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Colon Cancer Cell Line ◽  
Colon Cancer Cell ◽  
Apoptotic Pathway ◽  
Pathway Gene
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