scholarly journals Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats

2012 ◽  
Vol 4 (5) ◽  
pp. 871-876 ◽  
Author(s):  
DONGHONG FANG ◽  
XUESI WAN ◽  
WANPING DENG ◽  
HONGYU GUAN ◽  
WEIJIAN KE ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Rats ◽  
Oxidative Stress Markers ◽  
Stress Markers

Effects ofPistacia atlanticaon Oxidative Stress Markers and Antioxidant Enzymes Expression in Diabetic Rats

2019 ◽  
Vol 38 (3) ◽  
pp. 267-274 ◽  
Author(s):  
Shahrokh Bagheri ◽  
Mostafa Moradi Sarabi ◽  
Peyman Khosravi ◽  
Reza Mohammadrezaei Khorramabadi ◽  
Saeid Veiskarami ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Diabetic Rats ◽  
Oxidative Stress Markers ◽  
Stress Markers

scholarly journals ANTIHYPERGLYCEMIC AND ANTIOXIDATIVE EFFECTS OF LYGODIUM MICROPHYLLUM IN ALLOXAN INDUCED DIABETIC RATS

2018 ◽  
Vol 10 (12) ◽  
pp. 75
Author(s):  
D. G. Syahidah Nadiah Binti Abdull Majid ◽  
Mohammad Iqbal
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Control Group ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Antioxidative Effects ◽  
And Oxidative Stress

Objective: The antihyperglycemic and antioxidative effects of L. microphyllum were evaluated by using in vivo methods in normal and alloxan induced diabetic rats.Methods: Diabetes was induced in Sprague Dawley rats by injecting alloxan through intravenous (i. v) at a dose of 100 mg/kg of body weight. Aqueous extract of L. microphyllum at different doses (400, 200 and 100 mg/kg of body weight) was administered orally (orogastric intubation) for 14 d. Blood glucose and oxidative stress markers were measured. Hematoxylin and eosin staining method were used to examine the pancreatic tissues.Results: At the 14 d interval, fasting blood glucose showed a reduction in serum glucose levels in animals pretreated with L. microphyllum compared with alloxan alone treated group. Oxidative stress was noticed in rat’s pancreatic tissue as evidenced by a significant decrease in glutathione level, glutathione reductase, glutathione-S-transferase, and catalase activities. Malondialdehyde showed a significant increase compared to the normal saline-treated control group. Serum biochemistry and oxidative stress markers were consistent with the pancreatic histopathological studies. Treatment of diabetic rats with L. microphyllum at a dose level of 100, 200 and 400 mg/kg body weight leaves extract for 14 d significantly prevented these alterations and attenuated alloxan-induced oxidative stress (P<0.05).Conclusion: The results of the present study indicated that the antihyperglycemic potential of L. microphyllum might be ascribable to its antioxidant and free radical scavenging properties. Thus, it is concluded that L. microphyllum may be helpful in the prevention of diabetic complications associated with oxidative stress.

Oxidative stress markers and apoptosis in the prostate of diabetic rats and the influence of vitamin C treatment

2012 ◽  
Vol 113 (7) ◽  
pp. 2223-2233 ◽  
Author(s):  
Marina Guimarães Gobbo ◽  
Daniele Lisboa Ribeiro ◽  
Sebastião Roberto Taboga ◽  
Eduardo Alves de Almeida ◽  
Rejane Maira Góes
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Diabetic Rats ◽  
Oxidative Stress Markers ◽  
Stress Markers

scholarly journals Hepatoprotective Activities of Ethanolic Roots Extract of Ageratum Conyzoides on Alloxan-Induced Hepatic Damage in Diabetic Wistar Rats

2018 ◽  
Vol 36 (01) ◽  
pp. 039-045 ◽  
Author(s):  
A.O. Ojewale ◽  
H.B. Akpan ◽  
F.A. Faduyile ◽  
P.D. Shallie ◽  
A.A. Akande ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Wistar Rats ◽  
Diabetic Rats ◽  
Hepatic Damage ◽  
Oxidative Stress Markers ◽  
Ageratum Conyzoides ◽  
Stress Markers

Introduction The aim of the present study was to evaluate the hepatoprotective activities of the ethanolic roots extract of Ageratum conyzoides (AC) in alloxan-induced hepatic damage in diabetic rats. Materials and Methods Diabetes was induced in Wistar rats by the administration of alloxan (150 mg/kg, intraperitoneal). The ethanolic roots extract of AC, at doses of 250 and 500 mg/kg of body weight, was administered to diabetes-induced rats at a single dose per day for a period of 28 days. Results The effect of the ethanolic roots extract of AC on blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatic oxidative stress markers was measured in the diabetic rats. The ethanolic roots extract of AC exhibited significant reduction of blood glucose (p < 0.05) at the dose of 500 mg/kg when compared with the standard drug glibenclamide (600 µg/kg). The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels increased significantly (p < 0.05) in the diabetic group without treatment when compared with the control group. In addition, the levels of oxidative stress markers, such as superoxide dismutase (SOD), catalase (CT), glutathione peroxidase (GPx), and glutathione (GSH), were significantly decreased in the diabetic rats compared with the normal rats, while the lipid peroxidation significantly increased in the diabetic group without treatment compared with the control (normal) group. The results demonstrated that the morphological, functional and oxidative stress changes in the liver caused by the ingestion of alloxan were attenuated in diabetic rats treated with the ethanolic roots extract of AC. Conclusion We concluded that the ethanolic roots extract of AC possesses significant antidiabetic, antioxidant and hepatoprotective effects on alloxan-induced diabetic rats.

Effect of Artemisia absinthium ethanolic extract on oxidative stress markers and the TLR4, S100A4, Bax and Bcl-2 genes expression in the kidney of STZ-induced diabetic rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Fatemeh Bagheri ◽  
Jamal Amri ◽  
Mehdi Salehi ◽  
Hadi Karami ◽  
Abbas Alimoradian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fasting Blood Glucose ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Herbal Extract ◽  
Oxidative Stress Markers ◽  
Artemisia Absinthium ◽  
Beneficial Effects ◽  
Stress Markers ◽  
Antidiabetic Effects

AbstractObjectivesThe present study was conducted to examine antidiabetic effects of Artemisia absinthium ethanolic extract [A. absinthium] and to investigate its effects on oxidative stress markers and the expression of TLR4, S100A4, Bax and Bcl-2 genes in the kidney of STZ-induced diabetic rats.MethodsThirty six rats (weight 200–250 g) were randomly divided into diabetes and control groups. Induction of diabetes was performed using STZ (55 mg/kg.bw). Biochemical parameters and oxidative stress markers (SOD and MDA) were measured using spectrophotometry after 60 days of treatment. The expression of TLR4, S100A4, Bax and Bcl-2 were analyzed by real-time PCR. One-way analysis of variance (ANOVA) and Bonferroni post hoc test were used to compare the data.ResultsDiabetes significantly impairs the serum fasting blood glucose (FBG), lipid profile, urea, creatinine and albumin. At the end of treatment with A. absinthium extract, these parameters were close to the normal range. The results showed that the A. absinthium extract significantly decreased the kidney expression of TLR4, S100A4, Bax and increased the expression of Bcl-2 and improved oxidative stress markers (SOD and MDA) in the kidney tissues of treated rats. Also, all of these beneficial effects of the A. absinthium were dose-dependent.ConclusionsThe extract of A. absinthium possesses antidiabetic effects. A. absinthium decreased the expression of TLR4, S100A4, Bax and increased the expression of Bcl-2 and improved oxidative stress. Therefore, this herbal extract can be used as an adjuvant treatment for diabetic complications.

scholarly journals Comparative Study on the Influence of Some Medicinal Plants on Diabetes Induced by Streptozotocin in Male Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Daklallah A. Almalki ◽  
Sameera A. Alghamdi ◽  
Atef M. Al-Attar
Keyword(s):  
Oxidative Stress ◽  
Saudi Arabia ◽  
Medicinal Plants ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Male Rats ◽  
Therapeutic Effects ◽  
Oxidative Stress Markers ◽  
Histopathological Alterations ◽  
Stress Markers

Medicinal plants have played an important role in the treatment of many diseases. Medicinal plants are believed to be well appropriate with the human body and to produce less side influences than the pharmaceuticals. Kingdom of Saudi Arabia has abundant and wide variety of medicinal plants whose therapeutic effects have not been adequately studied. The aim of this study was to investigate the hypoglycemic activities of the extracts of three plant species collected from Albaha region of Saudi Arabia including Olea oleaster (Oleaceae family) leaves (OLE), Juniperus procera (Cupressaceae family) leaves (JLE), and Opuntia ficus-indica (Cactaceae family) stems (OSE) on streptozotocin (STZ) diabetic male rats. The animals were distributed into eight groups. The first group was used as normal control. The second group was diabetic control. Diabetic rats of the third, fourth, and fifth groups were supplemented with OLE, JLE, and OSE, respectively. Normal rats of the sixth, seventh, and eighth groups were treated with OLE, JLE, and OSE, respectively. As expected, the mean of body weight was significantly decreased in rats of the second group. Significant increase in the value of serum glucose and decline of insulin value were observed in rats of the second group. Several alterations of lipid and protein profile and oxidative stress markers were noted in diabetic control rats. Severe histopathological alterations of pancreatic tissues were observed in untreated diabetic rats. The obtained results showed that OLE, JLE, and OSE attenuated the physiological and histopathological alterations. These new data indicate that the attenuation influences of OLE, JLE, and OSE attributed to their antioxidant properties confirmed by oxidative stress markers evaluation.

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