scholarly journals Predictive value of the pathological extent of tumor invasion in endoscopic resection margins positive for residual tumor cells in surgically resected specimens of early gastric cancer

2012 ◽  
Vol 4 (3) ◽  
pp. 507-513 ◽  
Author(s):  
HIRONORI TSUJIMOTO ◽  
SHO OGATA ◽  
YOSHIHISA YAGUCHI ◽  
ISAO KUMANO ◽  
RISA TAKAHATA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Tumor Cells ◽  
Endoscopic Resection ◽  
Predictive Value ◽  
Tumor Invasion ◽  
Residual Tumor ◽  
Resection Margins

Sa1647 Predictors of Lymph Node Metastasis and Residual Tumor in Non-Curative Endoscopic Resection of Early Gastric Cancer

2014 ◽  
Vol 79 (5) ◽  
pp. AB288
Author(s):  
Hyo-Joon Yang ◽  
Sang Gyun Kim ◽  
Joo Hyun Lim ◽  
Jeongmin Choi ◽  
Jong Pil IM ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Endoscopic Resection ◽  
Residual Tumor ◽  
Node Metastasis

scholarly journals Preprocedural prediction of non-curative endoscopic submucosal dissection for early gastric cancer.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 74-74
Author(s):  
Cheol Woong Choi ◽  
Dae Hwan Kang ◽  
Su Jin Kim
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Endoscopic Resection ◽  
Predictive Factors ◽  
Lesion Size ◽  
Treatment Modalities ◽  
Resection Margins ◽  
Tertiary Referral Hospital ◽  
Submucosal Dissection

74 Background: Endoscopic submucosal dissection (ESD) has been accepted as the treatment of choice for early gastric cancer (EGC) without lymph node metastasis. However, additional surgical gastrectomy should be considered after non-curative endoscopic resection. We aimed to evaluate the predictive factors associated with non-curative endoscopic resection. Methods: Between November 2008 and June 2015, a retrospective study was conducted in a single, tertiary, referral hospital. A total of 596 EGC lesions resected by ESD were analyzed. Non-curative endoscopic resection was defined as the occurrence of lesions associated with piecemeal resection, positive resection margins, lymphovascular invasion, or lesions that did not meet the expanded indications for ESD. Results: The rate of non-curative endoscopic resection was 16.1%. The mean follow-up period was 35.3 ± 25.0 months. Associated predictive factors for non-curative endoscopic resection were female sex (OR, 2.470; p = 0.004), lesion size ≥ 20 mm (OR 3.714; p < 0.001), longer procedure time (OR 2.449, p = 0.002), ulceration (OR 3.538, p = 0.002), nodularity (OR 2.967, p < 0.001), depression (OR 1.806, p = 0.038), undifferentiated carcinoma (OR 2.825, p = 0.031) and lesion located in the mid or upper third of stomach (OR 7.135 and OR 4.155, p < 0.001, respectively). As the number of risk factors increased, the risk of non-curative ESD also increased. Conclusions: Prior to selection of ESD, the risks associated with non-curative ESD should be considered so that appropriate treatment modalities may be selected.

Comparison of endoscopic resection and gastrectomy for the treatment of early gastric cancer: a meta-analysis

2015 ◽  
Vol 30 (9) ◽  
pp. 3673-3683 ◽  
Author(s):  
Fan-Sheng Meng ◽  
Zhao-Hong Zhang ◽  
Ya-Mei Wang ◽  
Lin Lu ◽  
Jin-Zhou Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Resection ◽  
Meta Analysis

scholarly journals Predictive value of risk score using Kyoto classification of gastritis a few years prior to diagnosis of early gastric cancer

JGH Open ◽  
2020 ◽  
Author(s):  
Yo Fujimoto ◽  
Yasumi Katayama ◽  
Yoshinori Gyotoku ◽  
Ryosuke Oura ◽  
Ikuhiro Kobori ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Risk Score ◽  
Predictive Value

scholarly journals Clinicopathological significance of primitive phenotypes in early gastric cancer with differentiated histology

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Zhi-Yi Zhou ◽  
Jie Sun ◽  
Qing Guo ◽  
Hai-Bin Zhao ◽  
Zhi-Hua Zhou
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Early Gastric Cancer ◽  
Endoscopic Resection ◽  
Independent Risk Factor ◽  
Lymphatic Invasion ◽  
Clinicopathological Features ◽  
Surgical Operation ◽  
Tissue Sections ◽  
Clinicopathological Significance

Abstract Background Certain gastric cancers exhibit some primitive phenotypes, which may indicate a high malignancy. In histologically differentiated early gastric cancer (EGC), the presence and the clinicopathological significance of the primitive phenotype remain unclear. Methods Using immunohistochemical staining we detected the expression of three primitive phenotypic markers SALL4, Glypican-3(GPC3), and AFP in whole tissue sections of differentiated EGC (gastrectomy specimens, n = 302). For those cases with primitive phenotypes, we analyzed their clinicopathological features and evaluated whether the criteria for endoscopic resection were met. Results We found that 9.3% (28/302) of all differentiated EGC cases have primitive phenotypes, and most of these cases (25/28) exhibit a histomorphology similar to conventional differentiated EGC. Patients with primitive phenotypes had a deeper invasion, a higher rate of ulcer and lymphatic invasion than cases without primitive phenotype. Moreover, patients with primitive phenotypes displayed a significantly higher frequency of LNM than those without (57.1% vs 8.8%, P < 0.001). Multivariate analysis revealed that presence of primitive phenotypes was an independent risk factor for LNM (P = 0.001, HR 6.977, 95% CI: 2.199–22.138). Interestingly, we found 2 cases with primitive phenotypes developed LNM, and they both met the expanded indications of endoscopic resection for differentiated EGC. Conclusions A small number of differentiated EGC have primitive phenotypes, which were closely related to LNM and were an independent risk factor for LNM. Given its highly aggressive behavior, differentiated EGC with primitive phenotypes should be evaluated with stricter criteria before endoscopic resection, or considered to give an additional surgical operation after endoscopic resection.

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