scholarly journals Folate receptor-mediated targeted polymeric gadolinium complexes for magnetic resonance imaging in pulmonary tumor xenografts

2012 ◽  
Vol 3 (5) ◽  
pp. 903-907 ◽  
Author(s):  
ZHENG YUAN ◽  
WEN-TAO LI ◽  
XIAO-DAN YE ◽  
SHI-YUAN LIU ◽  
XIANG-SHENG XIAO
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Folate Receptor ◽  
Resonance Imaging ◽  
Tumor Xenografts ◽  
Pulmonary Tumor ◽  
Gadolinium Complexes

scholarly journals PAMAM Dendrimers as Potential Carriers of Gadolinium Complexes of Iminodiacetic Acid Derivatives for Magnetic Resonance Imaging

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Magdalena Markowicz-Piasecka ◽  
Joanna Sikora ◽  
Paweł Szymański ◽  
Oliwia Kozak ◽  
Michał Studniarek ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Plasma Concentrations ◽  
Iminodiacetic Acid ◽  
Pamam Dendrimers ◽  
Clot Formation ◽  
Increase Signal Intensity ◽  
Resonance Imaging ◽  
Gadolinium Complexes ◽  
Biodistribution Studies

This is the first study describing the utilization of PAMAM dendrimers as delivery vehicles of novel magnetic resonance imaging (MRI) contrast agents. The purpose of this paper was to establish the potential of G4 PAMAM dendrimers as carriers of gadolinium complexes of iminodiacetic acid derivatives and determine imaging properties of synthesized compounds inin vivostudies. Furthermore, we examined the influence of four synthesized complexes on the process of clot formation, stabilization, and lysis and on amidolytic activity of thrombin. Biodistribution studies have shown that the compounds composed of PAMAM G4 dendrimers and gadolinium complexes of iminodiacetic acid derivatives increase signal intensity preferably in liver in range of 59–116% in MRI studies which corresponds with the greatest accumulation of gadolinium after administration of the compounds. Synthesized compounds affect kinetic parameters of the proces of clot formation, its stabilization, and lysis. However, only one synthesized compound at concentration 10-fold higher than potential plasma concentrations contributed to the increase of general parameters such as the overall potential of clot formation and lysis (↑CLAUC) and total time of the process (↑T). Results of described studies provide additional insight into delivery properties of PAMAM dendrimers but simultaneously underscore the necessity for further research.

Gadolinium complexes of macrocyclic diethylenetriamine-N-oxide pentaacetic acid-bisamide as highly stable MRI contrast agents with high relaxivity

2020 ◽  
Vol 49 (26) ◽  
pp. 8927-8932
Author(s):  
Kehan Xu ◽  
Na Xu ◽  
Beibei Zhang ◽  
Weijun Tang ◽  
Yun Ding ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Gadolinium Complexes ◽  
High Relaxivity ◽  
Magnetic Resonance Imaging Mri

Macrocyclic gadolinium(iii) complexes with hyphenated-amino-N-oxide (HAO) type ligand structures are designed as efficient magnetic resonance imaging (MRI) contrast agents (CAs) with high relaxivity and stability.

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