scholarly journals Global dysregulation of the chromosome 14q32 imprinted region in uterine carcinosarcoma

2012 ◽  
Vol 3 (4) ◽  
pp. 677-682 ◽  
Author(s):  
ERIC J. DEVOR ◽  
JILLIAN N. DE MIK ◽  
SHYAM RAMACHANDRAN ◽  
MICHAEL J. GOODHEART ◽  
KIMBERLY K. LESLIE
Keyword(s):  
Uterine Carcinosarcoma ◽  
Chromosome 14Q32

scholarly journals Hyaluronan-mediated motility receptor expression functions as a prognostic biomarker in uterine carcinosarcoma based on bioinformatics analysis

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110210
Author(s):  
Hui Sun ◽  
Li Ma ◽  
Jie Chen
Keyword(s):  
Interaction Network ◽  
Maximal Clique ◽  
Receptor Expression ◽  
The Cancer Genome Atlas ◽  
Uterine Carcinosarcoma ◽  
Sequencing Data ◽  
Hub Genes ◽  
Protein Protein Interaction ◽  
Normal Tissues ◽  
Potential Biomarker

Objective Uterine carcinosarcoma (UCS) is a rare, aggressive tumour with a high metastasis rate and poor prognosis. This study aimed to explore potential key genes associated with the prognosis of UCS. Methods Transcriptional expression data were downloaded from the Gene Expression Profiling Interactive Analysis database and differentially expressed genes (DEGs) were subjected to Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses using Metascape. A protein–protein interaction network was constructed using the STRING website and Cytoscape software, and the top 30 genes obtained through the Maximal Clique Centrality algorithm were selected as hub genes. These hub genes were validated by clinicopathological and sequencing data for 56 patients with UCS from The Cancer Genome Atlas database. Results A total of 1894 DEGs were identified, and the top 30 genes were considered as hub genes. Hyaluronan-mediated motility receptor (HMMR) expression was significantly higher in UCS tissues compared with normal tissues, and elevated expression of HMMR was identified as an independent prognostic factor for shorter survival in patients with UCS. Conclusions These results suggest that HMMR may be a potential biomarker for predicting the prognosis of patients with UCS.

Characterization of a newly established uterine carcinosarcoma cell line featuring the sarcomatous phenotype of the tumor in vitro

2008 ◽  
Vol 18 (2) ◽  
pp. 339-344 ◽  
Author(s):  
H.-J. Schulten ◽  
J. Wolf-Salgó ◽  
C. Gründker ◽  
B. Gunawan ◽  
L. FÜZESI
Keyword(s):  
Cell Line ◽  
Hormone Receptors ◽  
Tumor Biology ◽  
Growth Factor Receptor ◽  
Population Doubling ◽  
Established Cell Line ◽  
Population Doubling Time ◽  
Uterine Carcinosarcoma ◽  
Specific Staining

We describe the newly established cell line CS-99 derived from a uterine carcinosarcoma retaining features of the sarcomatous phenotype in vitro. CS-99 cells exhibit a mesenchymal morphology with predominantly spindle-shaped cells at nonconfluence turning to pleomorphic appearance at confluence. The mesenchymal phenotype was evidenced immunohistochemically by strong vimentin and moderate SM-actin, which was similar to the sarcomatous component of the primary tumor. P53 was overexpressed in a subset of CS-99 cells. Epithelial membrane antigen was moderately expressed whereas other markers including pan CK, CK 5/6, CK 34, epidermal growth factor receptor, desmin, carcinoembryonic antigen, S100, KIT, ERBB2, and the hormone receptors, estrogen receptor and progesterone receptor revealed either weak or no specific staining in CS-99 cells. High self-renewal capacity corresponded to the population doubling time of 23 h in high passage. CS-99 cells were able to develop three-dimensional tumor spheroids in vitro. Cytogenetic analysis and multicolor fluorescence in situ hybridization of CS-99 demonstrated an almost stable karyotype including numerical changes +8, +18, and +20 and translocations, amongst others der(1)t(1;2), der(1)t(1;7), der(2)t(2;19), der(5)t(5;8), and der(5)t(5;14). Taken together, the cell line CS-99 exhibits strong growths dynamics and a complex but stable karyotype in higher passages, and can be further a useful in vitro model system for studying tumor biology of carcinosarcomas.

scholarly journals Serum CA125 predicts extrauterine disease and survival in uterine carcinosarcoma

2007 ◽  
Vol 107 (3) ◽  
pp. 513-517 ◽  
Author(s):  
Gloria S. Huang ◽  
Lydia G. Chiu ◽  
Juliana S. Gebb ◽  
Marc J. Gunter ◽  
Paniti Sukumvanich ◽  
...  
Keyword(s):  
Uterine Carcinosarcoma ◽  
Serum Ca125

scholarly journals RNA-seq Identification of RACGAP1 as a Metastatic Driver in Uterine Carcinosarcoma

2016 ◽  
Vol 22 (18) ◽  
pp. 4676-4686 ◽  
Author(s):  
Shijun Mi ◽  
Mingyan Lin ◽  
Jurriaan Brouwer-Visser ◽  
Jennifer Heim ◽  
David Smotkin ◽  
...  
Keyword(s):  
Rna Seq ◽  
Uterine Carcinosarcoma

Yolk Sac Tumor Arising in Uterine Carcinosarcoma With Endometrioid and Serous Components

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Samuel Grindstaff ◽  
Linda C. Hanley ◽  
Natalie Banet
Keyword(s):  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
Uterine Carcinosarcoma

Comparing paclitaxel-platinum with ifosfamide-platinum as the front-line chemotherapy for patients with advanced-stage uterine carcinosarcoma

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ming-Hsuan Su ◽  
Hua-Hsi Wu ◽  
Hsin-Yi Huang ◽  
Na-Rong Lee ◽  
Wen-Hsun Chang ◽  
...  
Keyword(s):  
Advanced Stage ◽  
Uterine Carcinosarcoma ◽  
Front Line ◽  
Line Chemotherapy
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