scholarly journals Functional dose-volume histograms for predicting radiation pneumonitis in locally advanced non-small cell lung cancer treated with late-course accelerated hyperfractionated radiotherapy

2011 ◽  
Vol 2 (5) ◽  
pp. 1017-1022 ◽  
Author(s):  
DONGQING WANG ◽  
BAOSHENG LI ◽  
ZHONGTANG WANG ◽  
JIAN ZHU ◽  
HONGFU SUN ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Radiation Pneumonitis ◽  
Locally Advanced ◽  
Small Cell ◽  
Small Cell Lung ◽  
Hyperfractionated Radiotherapy ◽  
Dose Volume Histograms ◽  
Dose Volume

scholarly journals Dose-volume parameters predict radiation pneumonitis after induction chemoradiotherapy followed by surgery for non-small cell lung cancer: a retrospective analysis

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Kuniaki Katsui ◽  
Takeshi Ogata ◽  
Kenta Watanabe ◽  
Norihisa Katayama ◽  
Junichi Soh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Radiation Pneumonitis ◽  
Lower Lobe ◽  
Small Cell ◽  
Lung Dose ◽  
Small Cell Lung ◽  
Factors Associated ◽  
Dose Volume

Abstract Background The relationship between lung dose-volume histogram (DVH) parameters and radiation pneumonitis (RP) associated with induction concurrent chemoradiotherapy (CCRT) followed by surgery in patients with non-small cell lung cancer (NSCLC) is unclear, particularly when concerning irradiation of the whole lung prior to resection. We performed this study to identify factors associated with grade ≥ 2 RP in such patients. Methods Patients who received induction CCRT (chemotherapy: cisplatin and docetaxel; radiotherapy: 46 Gy/23 fractions) between May 2003 and May 2017 were reviewed. The mean lung dose (MLD) and the percentage of the lung volume that received ≥5 Gy (V5) and ≥ 20 Gy (V20) were calculated. Factors associated with the development of grade ≥ 2 RP were analyzed. Results One hundred and eight patients were included in this study, 34 (31.5%) of whom experienced grade ≥ 2 RP. A V20 ≥ 21%, an MLD ≥10 Gy, and a lower lobe tumor location were significant predictors of grade ≥ 2 RP on univariate analysis (p = 0.007, 0.002, and 0.004, respectively). Moreover, an MLD ≥10 Gy and lower lobe location were significant predictors of grade ≥ 2 RP on multivariate analysis (p = 0.026 and 0.0043, respectively). The cumulative incidence rates of grade ≥ 2 RP at 6 months were 15.7 and 45.6% in patients with MLDs < 10 Gy and ≥ 10 Gy, respectively, and were 23.5 and 55.6% in patients with upper/middle lobe- vs. lower lobe-located tumors, respectively. Conclusions MLD and lower lobe location were predictors of grade ≥ 2 RP in patients who received induction CCRT. It is necessary to reduce the MLD to the greatest extent possible to prevent the occurrence of this adverse event.

scholarly journals Factors predicting radiation pneumonitis in locally advanced non-small cell lung cancer

2011 ◽  
Vol 29 (3) ◽  
pp. 181 ◽  
Author(s):  
Myungsoo Kim ◽  
Jihae Lee ◽  
Boram Ha ◽  
Rena Lee ◽  
Kyung-Ja Lee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Radiation Pneumonitis ◽  
Locally Advanced ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Radiation pneumonitis after definitive concurrent chemoradiotherapy with cisplatin/docetaxel for non‐small cell lung cancer: Analysis of dose‐volume parameters

2020 ◽  
Vol 9 (13) ◽  
pp. 4540-4549
Author(s):  
Kuniaki Katsui ◽  
Takeshi Ogata ◽  
Kenta Watanabe ◽  
Norihisa Katayama ◽  
Masahiro Kuroda ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Concurrent Chemoradiotherapy ◽  
Radiation Pneumonitis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Dose Volume
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