scholarly journals Inhibitory effect of dietary atorvastatin and celecoxib together with voluntary running wheel exercise on the progression of androgen-dependent LNCaP prostate tumors to androgen independence

2011 ◽  
Vol 2 (2) ◽  
pp. 221-228 ◽  
Author(s):  
XI ZHENG ◽  
XIAO-XING CUI ◽  
ZHI GAO ◽  
YANG ZHAO ◽  
YI SHI ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Running Wheel ◽  
Prostate Tumors ◽  
Androgen Independence ◽  
Voluntary Running ◽  
Running Wheel Exercise

Phenethyl isothiocyanate in combination with dibenzoylmethane inhibits the androgen-independent growth of prostate cancer cells

2018 ◽  
Vol 9 (4) ◽  
pp. 2398-2408 ◽  
Author(s):  
Huarong Huang ◽  
Yan He ◽  
Lanyue Zhang ◽  
Hongping Xiang ◽  
Dongli Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Phenethyl Isothiocyanate ◽  
Prostate Cancer Cells ◽  
Prostate Tumors ◽  
Androgen Independence ◽  
Androgen Independent

This study investigates the inhibitory effect of PEITC and DBM in combination on the progression of androgen-dependent VCaP prostate tumors to androgen independence.

scholarly journals Pro-inflammatory Vascular Stress in Spontaneously Hypertensive Rats Associated With High Physical Activity Cannot Be Attenuated by Aldosterone Blockade

2021 ◽  
Vol 8 ◽  
Author(s):  
Rolf Schreckenberg ◽  
Annemarie Wolf ◽  
Christian Troidl ◽  
Sakine Simsekyilmaz ◽  
Klaus-Dieter Schlüter
Keyword(s):  
Physical Activity ◽  
Vascular Wall ◽  
Hypertensive Rats ◽  
Running Wheel ◽  
Spontaneously Hypertensive ◽  
High Physical Activity ◽  
Beneficial Effects ◽  
Voluntary Running ◽  
Running Wheel Exercise ◽  
Wheel Activity

The effect of high physical activity, performed as voluntary running wheel exercise, on inflammation and vascular adaptation may differ between normotensive and spontaneously hypertensive rats (SHRs). We investigated the effects of running wheel activity on leukocyte mobilization, neutrophil migration into the vascular wall (aorta), and transcriptional adaptation of the vascular wall and compared and combined the effects of high physical activity with that of pharmacological treatment (aldosterone antagonist spironolactone). At the start of the 6th week of life, before hypertension became established in SHRs, rats were provided with a running wheel over a period of 10-months'. To investigate to what extent training-induced changes may underlie a possible regression, controls were also generated by removal of the running wheel for the last 4 months. Aldosterone blockade was achieved upon oral administration of Spironolactone in the corresponding treatment groups for the last 4 months. The number of circulating blood cells was quantified by FACS analysis of peripheral blood. mRNA expression of selected proteins was quantified by RT-PCR. Histology and confocal laser microscopy were used to monitor cell migration. Although voluntary running wheel exercise reduced the number of circulating neutrophils in normotensive rats, it rather increased it in SHRs. Furthermore, running wheel activity in SHRs but not normotensive rats increased the number of natural killer (NK)-cells. Except of the increased expression of plasminogen activator inhibitor (PAI)-1 and reduction of von Willebrand factor (vWF), running wheel activity exerted a different transcriptional response in the vascular tissue of normotensive and hypertensive rats, i.e., lack of reduction of the pro-inflammatory IL-6 in vessels from hypertensive rats. Spironolactone reduced the number of neutrophils; however, in co-presence with high physical activity this effect was blunted. In conclusion, although high physical activity has beneficial effects in normotensive rats, this does not predict similar beneficial effects in the concomitant presence of hypertension and care has to be taken on interactions between pharmacological approaches and high physical activity in hypertensives.

miR21 is Associated with the Cognitive Improvement Following Voluntary Running Wheel Exercise in TBI Mice

2015 ◽  
Vol 57 (1) ◽  
pp. 114-122 ◽  
Author(s):  
Tao Hu ◽  
Feng-Jie Zhou ◽  
Ye-Fei Chang ◽  
Ya-Shan Li ◽  
Guang-Cai Liu ◽  
...  
Keyword(s):  
Running Wheel ◽  
Cognitive Improvement ◽  
Voluntary Running ◽  
Running Wheel Exercise

Vascular adaptations in rat hindlimb skeletal muscle after voluntary running-wheel exercise

1995 ◽  
Vol 79 (1) ◽  
pp. 287-296 ◽  
Author(s):  
W. L. Sexton
Keyword(s):  
Skeletal Muscle ◽  
Transport Capacity ◽  
Running Wheel ◽  
Capillary Filtration ◽  
Vascular Transport ◽  
Flow Capacity ◽  
Voluntary Running ◽  
Capillary Filtration Coefficient ◽  
Running Wheel Exercise ◽  
Long Head

To test the hypothesis that voluntary running-wheel exercise would elicit vascular adaptations in rat skeletal muscle, male Sprague-Dawley rats (202 +/- 5 g) were cage confined (C, n = 11) or housed in cages with free access to running wheels (R, n = 13) for 12 wk. Vascular transport capacity was determined in maximally vasodilated (papaverine) hindquarters of C and R rats with measurements of total and regional (radiolabeled microspheres) flow capacity and capillary filtration coefficient. R rats voluntarily ran 29 +/- 4 km/wk over the 12-wk period; however, performance of individual rats varied greatly (range 4–74 km/wk). Citrate synthase activity was increased in the medial head (81%, P < 0.001) and the red long head (88%, P < 0.001) of the triceps brachii muscle in R rats but not in the white long head (25%, P = 0.06). Capillary filtration coefficient was 27% greater in R compared with C rats (0.040 +/- 0.003 vs. 0.031 +/- 0.002 ml.min-1.100 g-1.mmHg-1, respectively, P < 0.001) suggesting that there was an increase in microvascular surface area available for fluid exchange. Total hindquarters flow was increased in R rats (P < 0.05) at all perfusion pressures examined, indicative of an increased flow capacity. Regional flows revealed that skin flow was unchanged in R rats and that the increase in total flow was due to increased skeletal muscle flow capacity. These results indicate that voluntary running-wheel exercise elicits adaptive increases in skeletal muscle vascular transport capacity and oxidative capacity comparable to those seen in treadmill-trained rats and support the use of voluntary running-wheel exercise as a less stressful training modality in exercise studies using rats.

scholarly journals Voluntary running-wheel exercise decreases the threshold for rewarding intracranial self-stimulation.

2012 ◽  
Vol 126 (4) ◽  
pp. 582-587 ◽  
Author(s):  
Michael J. Morris ◽  
Elisa S. Na ◽  
Alan Kim Johnson
Keyword(s):  
Running Wheel ◽  
Voluntary Running ◽  
Running Wheel Exercise ◽  
Self Stimulation
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