scholarly journals Effect of cytokine treatment on the expression and secretion of brain derived neurotrophic factor in the smooth muscle of the rat colon

2020 ◽  
Vol 13 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Mohammad Al Qudah ◽  
Mahmoud Alfaqih ◽  
Othman Al-Shboul ◽  
Rami Saadeh ◽  
Ahmed Al-Dwairi
Keyword(s):  
Smooth Muscle ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Rat Colon ◽  
Cytokine Treatment

scholarly journals Smooth muscle brain‐derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma

2018 ◽  
Vol 33 (2) ◽  
pp. 3024-3034 ◽  
Author(s):  
Rodney D. Britt ◽  
Michael A. Thompson ◽  
Sarah A. Wicher ◽  
Logan J. Manlove ◽  
Anne Roesler ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Mouse Model ◽  
Allergic Asthma ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Airway Hyperreactivity

scholarly journals TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle

2013 ◽  
Vol 1833 (12) ◽  
pp. 2953-2960 ◽  
Author(s):  
Pawan K. Vohra ◽  
Michael A. Thompson ◽  
Venkatachalem Sathish ◽  
Alexander Kiel ◽  
Calvin Jerde ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Human Airway Smooth Muscle ◽  
Human Airway

scholarly journals Brain-Derived Neurotrophic Factor Enhances Calcium Regulatory Mechanisms in Human Airway Smooth Muscle

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e44343 ◽  
Author(s):  
Amard J. Abcejo ◽  
Venkatachalem Sathish ◽  
Dan F. Smelter ◽  
Bharathi Aravamudan ◽  
Michael A. Thompson ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Regulatory Mechanisms ◽  
Human Airway Smooth Muscle ◽  
Human Airway

Hyperoxia enhances brain-derived neurotrophic factor and tyrosine kinase B receptor expression in peribronchial smooth muscle of neonatal rats

2005 ◽  
Vol 289 (2) ◽  
pp. L307-L314 ◽  
Author(s):  
Qin Yao ◽  
Musa A. Haxhiu ◽  
Syed I. Zaidi ◽  
Shijian Liu ◽  
Anjum Jafri ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Airway Hyperreactivity ◽  
Receptor Expression ◽  
Postnatal Life ◽  
Bdnf Mrna ◽  
Protein Levels ◽  
Rat Pups ◽  
Hyperoxic Exposure

Airway hyperreactivity is one of the hallmarks of hyperoxic lung injury in early life. As neurotrophins such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are potent mediators of neuronal plasticity, we hypothesized that neurotrophin levels in the pulmonary system may be disturbed by hyperoxic exposure. We therefore evaluated the effects of hyperoxia on the expression of BDNF, NGF, and their corresponding high-affinity receptors, TrkB and TrkA, respectively, in the lung of rat pups. Five-day-old Sprague-Dawley rat pups were randomized to hyperoxic or control groups and then continuously exposed to hyperoxia (>95% oxygen) or normoxia over 7 days. At both mRNA and protein levels, BDNF was detected in lung but not in trachea; its level was substantially enhanced in lungs from the hyperoxia-exposed rat pups. Distribution of BDNF mRNA by in situ hybridization indicates that peribronchial smooth muscle was the major source of increased BDNF production in response to hyperoxic exposure. Interestingly, hyperoxia-induced elevation of BDNF was not accompanied by any changes of NGF levels in lung. Furthermore, hyperoxic exposure increased the expression of TrkB in peribronchial smooth muscle but had no effect on the distribution of the specific NGF receptor TrkA. These findings indicate that hyperoxic stress not only upregulates BDNF at mRNA and protein levels but also enhances TrkB within peribronchial smooth muscle. However, there was no corresponding effect on NGF and TrkA receptors. We speculate that the increased level of BDNF may contribute to hyperoxia-induced airway hyperresponsiveness in early postnatal life.

scholarly journals Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth Muscle

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0129489 ◽  
Author(s):  
William Hartman ◽  
Martin Helan ◽  
Dan Smelter ◽  
Venkatachalem Sathish ◽  
Michael Thompson ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Pulmonary Artery ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Pulmonary Artery Smooth Muscle ◽  
Human Pulmonary Artery
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