scholarly journals Computer‑aided design of temozolomide derivatives based on alkylglycerone phosphate synthase structure with isothiocyanate and their pharmacokinetic/toxicity prediction and anti‑tumor activity in vitro

2018 ◽  
Author(s):  
Bing Yang ◽  
Xiaobo Li ◽  
Lu He ◽  
Yu Zhu
Keyword(s):  
Computer Aided Design ◽  
Toxicity Prediction ◽  
Computer Aided ◽  
Aided Design ◽  
Anti Tumor Activity ◽  
Phosphate Synthase

scholarly journals Application Solid Laser-Sintered or Machined Ti6Al4V Alloy in Manufacturing of Dental Implants and Dental Prosthetic Restorations According to Dentistry 4.0 Concept

Processes ◽  
2020 ◽  
Vol 8 (6) ◽  
pp. 664 ◽  
Author(s):  
Leszek A. Dobrzański ◽  
Lech B. Dobrzański ◽  
Anna Achtelik-Franczak ◽  
Joanna Dobrzańska
Keyword(s):  
Dental Implants ◽  
Computer Aided Design ◽  
Bending Strength ◽  
Ti6al4v Alloy ◽  
Cnc Machining ◽  
Live Cells ◽  
Computer Aided ◽  
Aided Design ◽  
The Impact

This paper presents a comparison of the impact of milling technology in the computer numerically controlled (CNC) machining centre and selective laser sintering (SLS) and on the structure and properties of solid Ti6Al4V alloy. It has been shown that even small changes in technological conditions in the SLS manufacturing variant significantly affect changes from two to nearly two and a half times in tensile and bending strengths. Both the tensile and bending strength obtained in the most favourable manufacturing variant by the SLS method is over 25% higher than in the case of cast materials subsequently processed by milling. Plug-and-play SLS conditions provide about 60% of the possibilities. Structural, tribological and electrochemical tests were carried out. In vitro biological tests using osteoblasts confirm the good tendency for the proliferation of live cells on the substrate manufactured under the most favourable SLS conditions. The use of SLS additive technology for the manufacturing of dental implants and abutments made of Ti6Al4V alloy in combination with the digitisation of dental diagnostics and computer-aided design and manufacture of computer-aided design/manufacturing (CAD/CAM) following the idea of Dentistry 4.0 is the best choice of technology for manufacturing of prosthetic and implant devices used in dentistry.

scholarly journals Comparison of Optical Properties of Laminate Veneers Made of Zolid FX and Katana UTML Zirconia and Lithium Disilicate Ceramics

2020 ◽  
Author(s):  
Fariborz Vafaei ◽  
Alireza Izadi ◽  
Samaneh Abbasi ◽  
Maryam Farhadian ◽  
Zahra Bagheri
Keyword(s):  
Experimental Study ◽  
Optical Properties ◽  
Computer Aided Design ◽  
Composite Resin ◽  
Lithium Disilicate ◽  
Laminate Material ◽  
Computer Aided ◽  
Aided Design ◽  
Laminate Veneers

Objectives: This study aimed to compare the optical properties of Zolid FX, Katana UTML, and lithium disilicate laminate veneers. Materials and Methods: In this in-vitro experimental study, the maxillary left lateral incisor of a phantom received a laminate veneer preparation. An impression was made, and a die was fabricated using dental stone. The die was scanned using a computer-aided design/computer-aided manufacturing scanner. Ten dies were fabricated from each of the A1, A2, and A3 shades of composite resin. Laminate veneers were fabricated using A1 shade of Katana UTML, Zolid FX, and IPS e.max CAD ceramics (n=10) and placed on composite abutments using bleach and white colors of trial insertion paste (TIP). The optical properties were measured at the incisal, middle, and cervical thirds using a spectrophotometer. Data were analyzed using three-way analysis of variance and Tukey’s test. Results: The effect of laminate material on the L*, a*, and b* parameters was significant in all areas (P<0.001), except for the L* parameter in the middle and cervical thirds. All color parameters were affected by TIP color in all three regions in most samples (P<0.05). The effect of composite abutment shade was also significant in most cases (P<0.05). The effect of laminate material, abutment shade, and TIP color on the b* parameter was significant (P<0.001). The L* parameter was almost the same in the two zirconia and lithium disilicate ceramic groups. Conclusion: The composite abutment shade, TIP color, and laminate material should be carefully selected to achieve optimal aesthetics in laminate veneers.

scholarly journals Development of a framework for whole-cell models creation

2019 ◽  
Author(s):  
Frederico Chaves Carvalho ◽  
Paulo Eduardo Ambrósio
Keyword(s):  
Computer Aided Design ◽  
Development Process ◽  
Scientific Discovery ◽  
Cell Models ◽  
Whole Cell ◽  
Early Stages ◽  
Computer Aided ◽  
Aided Design

The use of whole-cell models in research has the potential to be a powerful tool for scientific discovery, allowing researchers to test hypotheses faster than using in-vitro or in vivo methods. Such models can be considered the equivalent of Computer Aided Design for Biology. However, given their complexity, it is still difficult to employ them as an instrument in investigations. In order to solve this problem, we are developing a framework with the purpose to guide and help scientists through the process of creating whole-cell models faster, enabling them to use these tools as part of their research. This paper brings details of the early stages of the framework’s development process

scholarly journals Efeito da fumaça de cigarro e escovação simulada na cêramica vítrea de dissilicato de lítio CAD/CAM

2021 ◽  
Vol 13 (4) ◽  
pp. e7296
Author(s):  
Magna Andréa Rabêlo Diógenes ◽  
Francisca Tauliane Lemos de Castro ◽  
Samara Kelly da Silva Cavalcante ◽  
Ana Carolina Matias Dinelly Pinto ◽  
Pedro Henrique Chaves Isaias ◽  
...  
Keyword(s):  
Computer Aided Design ◽  
Lithium Disilicate ◽  
Computer Aided Manufacturing ◽  
Computer Aided ◽  
Cad Cam ◽  
Aided Design

Objetivo: Revisar acerca do efeito da fumaça do cigarro, associada ou não à escovação, na rugosidade superficial e na microdureza de uma cerâmica vítrea de dissilicato de lítio “Computer-Aided Design/Computer-Aided Manufacturing” (CAD/CAM). Métodos: Pesquisaram-se os descritores cadastrados no MeSH “lithium disilicate”, “smoking”, “CAD CAM”, “brushing”, “rough”, “hardness”, combinados entre si pelo operador booleano “AND”, na base de dados PubMed nos últimos 5 anos. Resultados: De acordo com a pesquisa, foram encontrados 625 artigos e selecionados 12 estudos in vitro. 5 estudos concluíram que as restaurações cerâmicas CAD/CAM apresentaram estabilidade de cor e de rugosidade da superfície, após escovação simulada e termociclagem.  4 estudos observaram que a escovação simulada e algumas bebidas aumentaram significativamente a rugosidade superficial da cerâmica de dissilicato de lítio. 3 estudos inferiram que a rugosidade superficial e a microdureza podem ser influenciadas pelos tratamentos de superfícies. Considerações finais: As cerâmicas de dissilicato de lítio CAD/CAM possuem propriedades satisfatórias em relação a sua resistência e estética, após exposição à fumaça do cigarro, associada ou não com a escovação.

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