scholarly journals Effect of branched‑chain amino acid supplementation on insulin resistance and quality of life in chronic hepatitis C patients

2017 ◽  
Author(s):  
Alicia Oca�a‑Mondrag�n ◽  
Jos� Mata‑Mar�n ◽  
Mario Uriarte‑L�pez ◽  
Carolina Bekker‑M�ndez ◽  
Enrique Alcal�‑Mart�nez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Amino Acid ◽  
Amino Acid Supplementation ◽  
Branched Chain Amino Acid ◽  
Branched Chain ◽  
Chronic Hepatitis C Patients

scholarly journals Disturbances in branched-chain amino acid profile and poor daily functioning in mildly depressed chronic obstructive pulmonary disease patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Marisa R. Pinson ◽  
Nicolaas E. P. Deutz ◽  
Rajesh Harrykissoon ◽  
Anthony J. Zachria ◽  
Mariëlle P. K. J. Engelen
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Amino Acid ◽  
Protein Intake ◽  
Chronic Obstructive ◽  
Mild Depression ◽  
Obstructive Pulmonary Disease ◽  
Branched Chain Amino Acid ◽  
Branched Chain

Abstract Background Depression is one of the most common and untreated comorbidities in chronic obstructive pulmonary disease (COPD), and is associated with poor health outcomes (e.g. increased hospitalization/exacerbation rates). Although metabolic disturbances have been suggested in depressed non-diseased conditions, comprehensive metabolic phenotyping has never been conducted in those with COPD. We examined whether depressed COPD patients have certain clinical/functional features and exhibit a specific amino acid phenotype which may guide the development of targeted (nutritional) therapies. Methods Seventy-eight outpatients with moderate to severe COPD (GOLD II–IV) were stratified based on presence of depression using a validated questionnaire. Lung function, disease history, habitual physical activity and protein intake, body composition, cognitive and physical performance, and quality of life were measured. Comprehensive metabolic flux analysis was conducted by pulse stable amino acid isotope administration. We obtained blood samples to measure postabsorptive kinetics (production and clearance rates) and plasma concentrations of amino acids by LC–MS/MS. Data are expressed as mean [95% CI]. Stats were done by graphpad Prism 9.1.0. ɑ < 0.05. Results The COPD depressed (CD, n = 27) patients on average had mild depression, were obese (BMI: 31.7 [28.4, 34.9] kg/m2), and were characterized by shorter 6-min walk distance (P = 0.055), physical inactivity (P = 0.03), and poor quality of life (P = 0.01) compared to the non-depressed COPD (CN, n = 51) group. Lung function, disease history, body composition, cognitive performance, and daily protein intake were not different between the groups. In the CD group, plasma branched chain amino acid concentration (BCAA) was lower (P = 0.02), whereas leucine (P = 0.01) and phenylalanine (P = 0.003) clearance rates were higher. Reduced values were found for tyrosine plasma concentration (P = 0.005) even after adjustment for the large neutral amino acid concentration (= sum BCAA, tyrosine, phenylalanine and tryptophan) as a marker of dopamine synthesis (P = 0.048). Conclusion Mild depression in COPD is associated with poor daily performance and quality of life, and a set of metabolic changes in depressed COPD that include perturbation of large neutral amino acids, specifically the BCAAs. Trial registration clinicaltrials.gov: NCT01787682, 11 February 2013—Retrospectively registered; NCT02770092, 12 May 2016—Retrospectively registered; NCT02780219, 23 May 2016—Retrospectively registered; NCT03796455, 8 January 2019—Retrospectively registered.

scholarly journals Quality of life in patients with chronic hepatitis C

2011 ◽  
Vol 139 (3-4) ◽  
pp. 165-169
Author(s):  
Sladjana Pavic ◽  
Dragan Delic ◽  
Jasmina Simonovic ◽  
Neda Svirtlih
Keyword(s):  
Quality Of Life ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Healthy Population ◽  
Chronic Liver Diseases ◽  
Chronic Hepatitis C Patients

Introduction. Hepatitis C virus often causes chronic liver disease reducing physical, mental and social functions in these patients. Objective. The aim of this investigation was analysis of the quality of life in chronic hepatitis C patients compared to patients with other chronic liver diseases and healthy population, as well as investigation of the influence of socio-demographic factors on the quality of life in patients with chronic hepatitis C. Methods. A generic Short Form-36 (SF-36) questionnaire and Chronic Liver Diseases Questionnaire (CLDQ) were used in this prospective study for the investigation of the quality of life in 160 patients (100 patients with chronic hepatitis C, 30 patients with chronic hepatitis B, 30 patients with non-viral chronic liver diseases) and 50 healthy controls. Results. Reduced quality of life was noted in patients with chronic hepatitis C patients in comparison with healthy controls (p=0.00). Significant differences in SF-36 were found between patients with chronic hepatitis C and B regarding physical functions, activity, physical pain and emotional functions. Multivariate linear regression analysis revealed ages below 50 years as the most important positive variable in chronic hepatitis C patients for total score of the quality of life and physical component score (B=14.5; SE=5.16; p=0.049; and B=16.4; SE=5.94; p=0.003, respectively). The most important positive variable for the mental component of the quality of life was male gender (B=15.3; SE=5.81; p=0.003). Conclusion. Quality of life is reduced in patients with chronic hepatitis C in comparison with healthy population. The quality of life in chronic hepatitis C patients is better than in patients with other non-viral chronic liver diseases. In comparison with patients with chronic hepatitis B, reduction in some domains of the quality of life is noted. Younger age is the most predictable group for the lowest damage of the total quality of life in patients with chronic hepatitis C patients among other socio- demographic characteristics of these patients.

Sign in / Sign up

Export Citation Format

Share Document