scholarly journals Expression of microphthalmia transcription factor, S100 protein, and HMB-45 in malignant melanoma and pigmented nevi

2016 ◽  
Vol 5 (3) ◽  
pp. 327-331 ◽  
Author(s):  
Jianxin Xia ◽  
Yanlong Wang ◽  
Fuqiu Li ◽  
Jinfeng Wang ◽  
Yan Mu ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Malignant Melanoma ◽  
S100 Protein ◽  
Microphthalmia Transcription Factor ◽  
Hmb 45 ◽  
Pigmented Nevi

S100 Protein and HMB-45 Negative “Rhabdoid” Malignant Melanoma:A Totally Dedifferentiated Malignant Melanoma?

1995 ◽  
Vol 103 (6) ◽  
pp. 772-773 ◽  
Author(s):  
William B. Laskin ◽  
Douglas R. Knittel ◽  
James N. Frame
Keyword(s):  
Malignant Melanoma ◽  
S100 Protein ◽  
Hmb 45

scholarly journals SOX11, SOX10 and MITF Gene Interaction: A Possible Diagnostic Tool in Malignant Melanoma

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 281
Author(s):  
Marius-Alexandru Beleaua ◽  
Ioan Jung ◽  
Cornelia Braicu ◽  
Doina Milutin ◽  
Simona Gurzu
Keyword(s):  
Malignant Melanoma ◽  
Tumor Cells ◽  
High Specificity ◽  
Gene Interaction ◽  
Prognostic Utility ◽  
Long Term Follow Up ◽  
Sox10 Expression ◽  
Microphthalmia Transcription Factor ◽  
Public Datasets ◽  
Hmb 45

Malignant melanoma (MM) is a highly heterogenic tumor whose histological diagnosis might be difficult. This study aimed to investigate the diagnostic and prognostic utility of the conventional pan-melanoma cocktail members (HMB-45, melan-A and tyrosinase), in conjunction with SOX10 and SOX11 immunohistochemical (IHC) expression. In 105 consecutive cases of MMs and 44 of naevi, the IHC examination was performed using the five-abovementioned markers, along with microphthalmia transcription factor (MITF), S100, and Ki67. Correlation with the clinicopathological factors and a long-term follow-up was also done. Survival analysis was performed with Kaplan–Meier curves and compared with TCGA public datasets. None of the 44 naevi expressed SOX11, but its positivity was seen in 52 MMs (49.52%), being directly correlated with lymphovascular invasion, the Ki67 index, and SOX10 expression. HMB-45, SOX10, and tyrosinase, but not melan-A, proved to differentiate the naevi from MMs successfully, with high specificity. Triple MITF/SOX10/SOX11 co-expression was seen in 9 out of 15 negative conventional pan-melanoma-cocktail cases. The independent prognostic value was proved for the conventional pan-melanoma cocktail (triple positivity for HMB-45, melan-A, and tyrosinase) and, independently for HMB-45 and tyrosinase, but not for melan-A, SOX10, or SOX11. As consequence, to differentiate MMs from benign naevi, melan-A should be substituted by SOX10 in the conventional cocktail. Although the conventional pan-melanoma cocktail, along with S100 can be used for the identification of melanocytic origin of tumor cells and predicting prognosis of MMs, the conventional-adapted cocktail (triple positivity for HMB-45, SOX10, and tyrosinase) has a slightly higher diagnostic specificity. SOX11 can be added to identify the aggressive MMs with risk for lymphatic dissemination and the presence of circulating tumor cells.

Malignant Melanoma of the Oral Mucosa in a 17-Year-Old Adolescent Girl

2002 ◽  
Vol 126 (9) ◽  
pp. 1110-1113 ◽  
Author(s):  
Nisha J. D'Silva ◽  
Zoya Kurago ◽  
Peter J. Polverini ◽  
Carl T. Hanks ◽  
Augusto F. Paulino
Keyword(s):  
Malignant Melanoma ◽  
Oral Cavity ◽  
Adolescent Girl ◽  
Hard Palate ◽  
Unusual Case ◽  
Clinical Presentation ◽  
S100 Protein ◽  
The United States ◽  
Second Molar ◽  
Microphthalmia Transcription Factor

Abstract Mucosal melanomas of the oral cavity are rarely seen in the United States. The hard palate is the most common intraoral site. This unusual case occurred in the oral cavity of a 17-year-old Asian girl, who presented to her dentist with complaints of pain and swelling in the upper jaw. The lesion was distal and palatal to the maxillary left second molar, which was vital. Interestingly, the clinical presentation was a hyperplastic, tender lesion that bled when probed. Histopathologically, the biopsy demonstrated a sheet of spindle-shaped cells arranged in nests and fascicles. The nuclei were vesicular, oval to spindle-shaped, and some contained nucleoli that were distinguishable but not prominent. No melanin pigment was observed in the lesion. Tumor cells strongly expressed S100 protein, gp100 (HMB-45), and microphthalmia transcription factor, and variably expressed MART1, but not cytokeratins, CD34, or muscle-specific actin. The histopathologic features and immunohistochemical findings are consistent with a diagnosis of malignant melanoma.

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