scholarly journals Club cell protein 16 as a biomarker in pulmonary contusion

2016 ◽  
Vol 5 (2) ◽  
pp. 251-253 ◽  
Author(s):  
Feng Wu ◽  
Boying Ding ◽  
Xiaolong Yang ◽  
Dongchun Ma ◽  
Chaodong Zhang ◽  
...  
Keyword(s):  
Pulmonary Contusion ◽  
Cell Protein ◽  
Club Cell

scholarly journals Club cell protein 16 and cytokeratin fragment 21-1 as early predictors of pulmonary complications in polytraumatized patients with severe chest trauma

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0175303 ◽  
Author(s):  
Lukas L. Negrin ◽  
Gabriel Halat ◽  
Stephan Kettner ◽  
Markus Gregori ◽  
Robin Ristl ◽  
...  
Keyword(s):  
Chest Trauma ◽  
Pulmonary Complications ◽  
Cell Protein ◽  
Club Cell ◽  
Early Predictors

scholarly journals Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype

2018 ◽  
Vol 51 (2) ◽  
pp. 1702146 ◽  
Author(s):  
Bartolome R. Celli ◽  
Nicholas Locantore ◽  
Ruth Tal-Singer ◽  
John Riley ◽  
Bruce Miller ◽  
...  
Keyword(s):  
Surfactant Protein ◽  
Forced Expiratory Volume ◽  
Fat Free Mass ◽  
Tissue Loss ◽  
Cell Protein ◽  
Surfactant Protein D ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Club Cell ◽  
Body Compartments

We tested whether emphysema progression accompanies enhanced tissue loss in other body compartments in 1817 patients from the ECLIPSE chronic obstructive pulmonary disease (COPD) cohort.Clinical and selected systemic biomarker measurements were compared in subjects grouped by quantitative tomography scan emphysema quartiles using the percentage of low attenuation area (LAA%). Lowest and highest quartile patients had amino-acid metabolomic profiles. We related LAA% to 3 years decline in lung function (forced expiratory volume in 1 s (FEV1)), body mass index (BMI), fat-free mass index (FFMI) and exacerbations, hospitalisations and mortality rates.Participants with more baseline emphysema had lower FEV1, BMI and FFMI, worse functional capacity, and less cardiovascular disease but more osteoporosis. Systemic C-reactive protein and interleukin-6 levels were similar among groups, but club cell protein 16 was higher and interleukin-8, surfactant protein D and soluble receptor for advanced glycation end product were lower with more emphysema. Metabolomics differed between extreme emphysema quartiles. Patients with more emphysema had accelerated FEV1, BMI and FFMI decline and more exacerbations, hospitalisations and mortality.COPD patients with more emphysema undergo excessive loss of pulmonary and extrapulmonary tissue, which is probably related to abnormal tissue maintenance. Because of worse clinical outcomes, we propose this subgroup be named the multi-organ loss of tissue (MOLT) COPD phenotype.

scholarly journals Pneumoproteins in Offshore Drill Floor Workers

2019 ◽  
Vol 16 (3) ◽  
pp. 300 ◽  
Author(s):  
Niels E. Kirkhus ◽  
Bente Ulvestad ◽  
Lars Barregard ◽  
Øivind Skare ◽  
Raymond Olsen ◽  
...  
Keyword(s):  
Strong Association ◽  
Surfactant Protein ◽  
Cell Protein ◽  
Surfactant Protein D ◽  
Drilling Mud ◽  
Air Concentration ◽  
Work Period ◽  
Club Cell ◽  
Before And After ◽  
Oil Mist

The aim was to assess pneumoproteins and a certain biomarker of systemic inflammation in drill floor workers exposed to airborne contaminants generated during drilling offshore, taking into consideration serum biomarkers of smoking, such as nicotine (S-Nico) and cotinine. Blood samples of club cell protein 16 (CC-16), surfactant protein D (SP-D) and C-reactive protein (CRP) were collected before and after a 14-day work period from 65 drill floor workers and 65 referents. Air samples of oil mist, drilling mud components and elemental carbon were collected in person. The drill floor workers were exposed to a median air concentration of 0.18 mg/m3 of oil mist and 0.14 mg/m3 of airborne mud particles. There were no differences in the concentrations of CC-16 and SP-D across the 14-day work period and no difference between drill floor workers and referents at baseline after adjusting for differences in sampling time and smoking. CRP decreased across the work period. There was a strong association between the CC-16 concentrations and the time of sampling. Current smokers with S-Nico > detection limit (DL) had a statistically significantly lower CC-16 concentration, while smokers with S-Nico <DL had CC-16 concentrations similar to that of the non-smokers. Fourteen days of work offshore had no effect on serum pneumoprotein and CRP concentrations. However, the time of blood sampling was observed to have a strong effect on the measured concentrations of CC-16. The effect of current smoking on the CC-16 concentrations appears to be dependent on the S-Nico concentrations.

scholarly journals Short halt in vaping modifies cardiorespiratory parameters and urine metabolome: a randomized trial

2020 ◽  
Vol 318 (2) ◽  
pp. L331-L344 ◽  
Author(s):  
Martin Chaumont ◽  
Vanessa Tagliatti ◽  
El Mehdi Channan ◽  
Jean-Marie Colet ◽  
Alfred Bernard ◽  
...  
Keyword(s):  
Oxygen Tension ◽  
Lung Function Test ◽  
Cell Protein ◽  
Lung Epithelium ◽  
Short Term ◽  
Baseline Serum ◽  
Transcutaneous Oxygen ◽  
Gas Exchanges ◽  
Club Cell ◽  
Urine Metabolome

Propylene glycol and glycerol are e-cigarette constituents that facilitate liquid vaporization and nicotine transport. As these small hydrophilic molecules quickly cross the lung epithelium, we hypothesized that short-term cessation of vaping in regular users would completely clear aerosol deposit from the lungs and reverse vaping-induced cardiorespiratory toxicity. We aimed to assess the acute effects of vaping and their reversibility on biological/clinical cardiorespiratory parameters [serum/urine pneumoproteins, hemodynamic parameters, lung-function test and diffusing capacities, transcutaneous gas tensions (primary outcome), and skin microcirculatory blood flow]. Regular e-cigarette users were enrolled in this randomized, investigator-blinded, three-period crossover study. The periods consisted of nicotine-vaping (nicotine-session), nicotine-free vaping (nicotine-free-session), and complete cessation of vaping (stop-session), all maintained for 5 days before the session began. Multiparametric metabolomic analyses were used to verify subjects’ protocol compliance. Biological/clinical cardiorespiratory parameters were assessed at the beginning of each session (baseline) and after acute vaping exposure. Compared with the nicotine- and nicotine-free-sessions, a specific metabolomic signature characterized the stop-session. Baseline serum club cell protein-16 was higher during the stop-session than the other sessions ( P < 0.01), and heart rate was higher in the nicotine-session ( P < 0.001). Compared with acute sham-vaping in the stop-session, acute nicotine-vaping (nicotine-session) and acute nicotine-free vaping (nicotine-free-session) slightly decreased skin oxygen tension ( P < 0.05). In regular e-cigarette-users, short-term vaping cessation seemed to shift baseline urine metabolome and increased serum club cell protein-16 concentration, suggesting a decrease in lung inflammation. Additionally, acute vaping with and without nicotine decreased slightly transcutaneous oxygen tension, likely as a result of lung gas exchanges disturbances.

scholarly journals Club Cell Protein, CC10, Attenuates Acute Respiratory Distress Syndrome Induced by Smoke Inhalation

Shock ◽  
2020 ◽  
Vol 53 (3) ◽  
pp. 317-326 ◽  
Author(s):  
Ernesto Lopez ◽  
Osamu Fujiwara ◽  
Christina Nelson ◽  
Melissa E. Winn ◽  
Richard S. Clayton ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Smoke Inhalation ◽  
Cell Protein ◽  
Club Cell

scholarly journals Sputum club cell protein concentration is associated with pulmonary exacerbation in cystic fibrosis

2015 ◽  
Vol 14 (3) ◽  
pp. 334-340 ◽  
Author(s):  
Theresa A. Laguna ◽  
Cynthia B. Williams ◽  
Kyle R. Brandy ◽  
Cole Welchlin-Bradford ◽  
Catherine E. Moen ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Protein Concentration ◽  
Cell Protein ◽  
Pulmonary Exacerbation ◽  
Club Cell

scholarly journals Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes

2013 ◽  
Vol 115 (10) ◽  
pp. 1450-1456 ◽  
Author(s):  
A. J. Simpson ◽  
E. Tufvesson ◽  
S. D. Anderson ◽  
L. M. Romer ◽  
L. Bjermer ◽  
...  
Keyword(s):  
Airway Epithelial Cells ◽  
Forced Expiratory Volume ◽  
Clara Cell ◽  
Cell Protein ◽  
Urinary Concentration ◽  
Airway Epithelial ◽  
Double Blind ◽  
Club Cell ◽  
Key Factor ◽  
Airway Epithelial Injury

Repeated injury of the airway epithelium caused by hyperpnoea of poorly conditioned air has been proposed as a key factor in the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. In animals, the short-acting β2-agonist terbutaline has been shown to reduce dry airflow-induced bronchoconstriction and the associated shedding of airway epithelial cells. Our aim was to test the efficacy of inhaled terbutaline in attenuating hyperpnoea-induced bronchoconstriction and airway epithelial injury in athletes. Twenty-seven athletes with EIB participated in a randomized, double-blind, placebo-controlled, crossover study. Athletes completed an 8-min eucapnic voluntary hyperpnoea (EVH) test with dry air on two separate days 15 min after inhaling 0.5 mg terbutaline or a matching placebo. Forced expiratory volume in 1 s (FEV1) and urinary concentration of the club cell (Clara cell) protein 16 (CC16, a marker of airway epithelial perturbation) were measured before and up to 60 min after EVH. The maximum fall in FEV1 of 17 ± 8% (SD) on placebo was reduced to 8 ± 5% following terbutaline ( P < 0.001). Terbutaline gave bronchoprotection (i.e., post-EVH FEV1 fall <10%) to 22 (81%) athletes. EVH caused an increase in urinary excretion of CC16 in both conditions ( P < 0.001), and terbutaline significantly reduced this rise (pre- to postchallenge CC16 increase 416 ± 495 pg/μmol creatinine after placebo vs. 315 ± 523 pg/μmol creatinine after terbutaline, P = 0.016). These results suggest that the inhalation of a single therapeutic dose of terbutaline offers significant protection against hyperpnoea-induced bronchoconstriction and attenuates acute airway epithelial perturbation in athletes.

scholarly journals Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Chun-Yu Wu ◽  
Ya-Jung Cheng ◽  
Ming-Hui Hung ◽  
I-Ju Lin ◽  
Wei-Zen Sun ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Distress Syndrome ◽  
Cell Protein ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Club Cell

Background. Acute respiratory distress syndrome (ARDS) after living-donor liver transplantation (LDLT) is not uncommon, but it lacks the biomarkers for early detection. Club cell protein 16 (CC16), high-motility group box 1 protein (HMGB1), interleukin-1β (IL-1β), and IL-10 have been reported as relevant to the development of ARDS. However, they have not been investigated during LDLT. Methods. Seventy-three consecutive recipients undergoing LDLT were enrolled and received the same perioperative care plan. Perioperative serum CC16, HMGB1, IL-1β, and IL-10 levels were measured at the pretransplant state, 30 minutes after reperfusion, postoperative day 1 (POD1), and POD3. ARDS was diagnosed according to the 2012 Berlin definition. Results. Of the 73 recipients, 13 developed ARDS with significantly longer durations of mechanical ventilation and intensive care unit stay. Serum CC16 levels on POD1 increased significantly from the pretransplant state in the ARDS group but not in the non-ARDS group. Pretransplant serum CC16 levels were also higher in the ARDS group. The area under the receiver operating characteristic curves for POD1 serum CC16 levels used to discriminate ARDS was 0.803 (95% confidence interval: 0.679 to 0.895; p < 0.001). By comparison, HMGB1, IL-1β, and IL-10 were not associated with ARDS after LDLT. Conclusion. The higher pretransplant serum CC16 level and its increased level on POD1 were associated with the development of early ARDS after LDLT. This trial is registered with NCT01936545, 27 August 2013.

Sign in / Sign up

Export Citation Format

Share Document