scholarly journals Presence of free triiodothyronine and free thyroxine in thyroid follicles may be correlated with the quick secretion of thyroid hormones under certain physiological conditions

2016 ◽  
Vol 4 (4) ◽  
pp. 467-470 ◽  
Author(s):  
HAIHONG SHI ◽  
WANRONG LIN ◽  
BO LIANG ◽  
HUIYAO CAI ◽  
QINGYAN CAI ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Free Thyroxine ◽  
Free Triiodothyronine ◽  
Physiological Conditions

RELATIONSHIPS BETWEEN BLOOD THYROTROPHIN LEVEL, PROTEIN BOUND IODINE AND FREE THYROXINE CONCENTRATION IN MAN UNDER NORMAL PHYSIOLOGICAL CONDITIONS

1969 ◽  
Vol 60 (2) ◽  
pp. 315-326 ◽  
Author(s):  
Th. Lemarchand-Béraud ◽  
A. Vannotti
Keyword(s):  
Thyroid Hormones ◽  
Healthy Subjects ◽  
Inverse Relationship ◽  
Free Thyroxine ◽  
Circadian Variations ◽  
Menstrual Cycles ◽  
Physiological Conditions ◽  
Significant Inverse Relationship ◽  
Relationship Of ◽  
Free Plasma

ABSTRACT A study of the thyroid-pituitary interrelationships in normal healthy subjects is carried out by measurements of plasma thyrotrophin (TSH), by a radioimmunoassay, protein bound iodine (PBI) and free thyroxine (T4). It has been found that: – PBI and TSH significantly increase with age, which probably results from a peripheral hypometabolism, in spite of a normal free T4 concentration; – there are circadian variations of free T4 accompanied by a non significant inverse relationship of the plasma TSH level; – no important changes occur during the normal menstrual cycles but there is a significant increase in both PBI and TSH during pregnancy. The secretion of pituitary TSH seems to be finely regulated not only by the free plasma thyroxine concentration but also by the rate of metabolism of the thyroid hormones in the cell.

scholarly journals Correlations of Free Thyroid Hormones Measured by Tandem Mass Spectrometry and Immunoassay with Thyroid-Stimulating Hormone across 4 Patient Populations

2009 ◽  
Vol 55 (7) ◽  
pp. 1380-1388 ◽  
Author(s):  
Jacqueline Jonklaas ◽  
Natasa Kahric-Janicic ◽  
Offie P Soldin ◽  
Steven J Soldin
Keyword(s):  
Mass Spectrometry ◽  
Thyroid Hormone ◽  
Tandem Mass Spectrometry ◽  
Thyroid Hormones ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
Tandem Mass ◽  
Free Triiodothyronine ◽  
Free Thyroid Hormones ◽  
Free Thyroid Hormone

Abstract Background: Accurate measurement of free thyroid hormones is important for managing thyroid disorders. Ultrafiltration liquid chromatography tandem mass spectrometry (LC-MS/MS) can reliably measure the concentrations of small molecules, including thyroid hormones. Our study was designed to compare free thyroid hormone measurements performed with immunoassay and LC-MS/MS. Methods: We studied the performance of LC-MS/MS in 4 different populations comprising pediatric patients, euthyroid adults, and healthy nonpregnant and pregnant women. The samples obtained from each population numbered 38, 200, 28, and 128, respectively. Free thyroxine, free triiodothyronine, and thyroid-stimulating hormone (TSH) concentrations were documented. Results: LC-MS/MS measurement of free thyroid hormones provided better correlation with log-transformed serum TSH in each population and also the populations combined. The correlations between free thyroxine measured by LC-MS/MS and log TSH in the pediatric outpatients and healthy adults were −0.90 and −0.77, respectively. The correlations for immunoassay were −0.82 and −0.48. The correlations between free triiodothyronine measured by LC-MS/MS and TSH for both pediatric and healthy adult populations were −0.72 and −0.68, respectively. Conclusions: Free thyroid hormone concentrations measured by LC-MS/MS correlate to a greater degree with log TSH values compared to concentrations measured by immunoassay. This correlation was maintained across the patient populations we studied and may reflect the accuracy and specificity of LC-MS/MS. The superior ability of LC-MS/MS to enable documentation of the well-known thyroid hormone–TSH relationship supports the use of this measurement technique in a variety of clinical situations.

scholarly journals Validation and Application of an Immunofluorimetric Assay for Detection of Serum Free Triiodothyronine and Free Thyroxine Concentrations in Buffalo (Bubalus Bubalis) under Various Physiological Conditions

2009 ◽  
Vol 21 (5) ◽  
pp. 668-673 ◽  
Author(s):  
Roberto Ambrosio ◽  
Maria Laura Sannino ◽  
Laura Cortese ◽  
Clemente Nappi ◽  
Daniela Ara ◽  
...  
Keyword(s):  
Bubalus Bubalis ◽  
Free Thyroxine ◽  
Average Sensitivity ◽  
Thyroid Activity ◽  
Free Triiodothyronine ◽  
Serum Free ◽  
Physiological Conditions ◽  
Coefficients Of Variation ◽  
Different Ages ◽  
Thyroid Metabolism

The current study was designed to validate an immunofluorimetric method to measure free triiodothyronine (fT3) and free thyroxine (fT4) concentrations in the serum of buffalo and to develop a better understanding of thyroid metabolism in buffalo ( Bubalus bubalis) of different ages and reproductive statuses. Free triiodothyronine and fT4 were determined in sera from 4 groups of 10 animals, each representing 5–10-year-old lactating buffalo, 2–3–year-old first calf heifers, 1–1.5-year-old virgin heifers, and 5–10–year-old dry buffalo. The average sensitivity of the immunofluorimetric assay was 5.9 pmol/l for fT3 and 14.7 pmol/l for fT4. Intra-assay and interassay coefficients of variation were 5.6% and 5.1% for fT3 and 1.5% and 4.3% for fT4, respectively. Virgin heifers had higher average values for fT3 and fT4, while lactating buffalo had the lowest average values. Dry buffalo and first calf heifers had intermediate fT3 and fT4 values. The findings of this study suggested that lactating buffalo were in a state of low thyroid activity, while virgin heifers had increased thyroid activity.

THYROID HORMONE THERAPY AND TREATMENT FOR WOMEN’S ABOVE 30 YEAR OLD WITH HYPOTHYROIDISM

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
N Rawat ◽  
S Saxena
Keyword(s):  
Immune System ◽  
Thyroid Hormone ◽  
Side Effects ◽  
Thyroid Hormones ◽  
Hormone Therapy ◽  
Free Thyroxine ◽  
Substitution Treatment ◽  
Free Triiodothyronine ◽  
Typical Condition ◽  
Serum Tsh

Thyroid hormones impact every single significant organ/frameworks and sufficient levels are significant for ideal capacity. Thyroid brokenness is a typical condition that effects somewhere in the range of 3 and 21% of the populace with predominance being increasingly regular in ladies and in more established people. Hypothyroidism is characterized by the expansion in thyroid-animating hormone (TSH) values, joined by diminished coursing free triiodothyronine (FT3) and free thyroxine (FT4). TSH is the most solid marker of sufficiency of substitution treatment, and an incentive inside the reference run (0.4–4.0 mIU/L) ought to be viewed as the helpful objective" have serum TSH esteems somewhere in the range of 0.4 and 2.5 mU/L. It is thusly contended that TSH esteems > 2.5 mU/L reflect hidden immune system thyroid ailment and add to the slanted TSH dissemination bend, a view additionally bolstered by the way that such people have a higher danger of movement to ensuing hypothyroidism. In this way, side effects of hypothyroidism are inadequate and vague in more established individuals. This prompts thyroid capacity tests being as often as possible mentioned. Then again, high thyroid capacity, as confirm by a low TSH level needs cautious observing and treatment considered if there is proof of end-organ harm, (for example, osteoporosis or AF), or if serum TSH is stifled. Keywords: TSH, Thyroid hormones, Hypothyroidism, FT4.

Determination of the prognosis of protracted non-psychotic mental diseases which are comorbid with thyroid pathology (adjustment disorder as the example)

2020 ◽  
pp. 32-46
Author(s):  
Irina Evgenievna Kupriyanova ◽  
Irina Sergeevna Karaush ◽  
Bairma Antonovna Dashieva ◽  
Valentina Borisovna Nikitina
Keyword(s):  
Thyroid Hormones ◽  
Blood Serum ◽  
Adjustment Disorder ◽  
Free Thyroxine ◽  
Control Group ◽  
Adjustment Disorders ◽  
Free Triiodothyronine ◽  
Thyroid Pathology ◽  
Mental Diseases

The possibility of predicting the progression of protracted adjustment disorder by determining a complex of clinical, psychological and laboratory indicators (free triiodothyronine (FT3) and free thyroxine (FT4) in blood serum) is considered in this article. The following methods have been used: clinical, psychological (determination of HADS alert level), laboratory (determination of thyroid hormones (T3 and T4) concentration in blood serum). 24 patients with adjustment disorders and thyroid comorbidity were examined. The tested indicators were compared with those of the control group (n = 15). The authors conclude that the determination of the features regarded as predictors of protracted adjustment disorder will make it possible to correct the treatment and improve its efficiency.

scholarly journals Thyroid Hormone levels in Highlanders- A Comparison Between Residents of Two Altitudes in Nepal

2014 ◽  
Vol 11 (1) ◽  
pp. 18-21 ◽  
Author(s):  
O Nepal ◽  
BR Pokharel ◽  
K Khanal ◽  
P Gyawali ◽  
SL Malik ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
High Altitude ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
High Altitudes ◽  
Free Triiodothyronine ◽  
Sea Bed ◽  
High Altitude Natives ◽  
Stimulating Hormone

Background The endocrine changes related to altitude adaptation in human have attracted physiologists around the globe for long. A number of high altitude studies to detect the physiological changes have been performed now and then. But, the study to see the hormonal changes to compare populations residing at different high altitudes is a scarce. Hence, we have performed a study in native populations of different high altitude comparing changes in thyroid hormones in western Nepal. The Jharkot population included in this study is at altitude of 3760m and Jomsom population at 2800m height from sea bed. Objective The study is to compare changes in thyroid hormones at two different high altitude natives. Methods To compare thyroid status between high altitude natives at two different altitudes a cross sectional study is performed by random sampling method. The blood sample was collected in a vacutainer from fifty eight individuals after obtaining the informed consent of participants. The blood collected from antecubital vein was centrifuged in an hour and the serum obtained was used for biochemical analysis of free triiodothyronine, free thyroxine and thyroid stimulating hormone. Results Mean free thyroxine (fT4) of Jharkot population is significantly larger (p = 0.001) than Jomsom population. Mean thyroid stimulating hormone (TSH) with p = 0.597, does not indicate the difference between this two population. There is no significant difference between mean free triiodothyronine (fT3) of Jharkot and Jomsom population (p = 0.345). Conclusion The rise in free thyroid hormone at high altitude is not dependent on the thyroid stimulating hormone released from anterior pituitary. The rise in free thyroxine is found at higher altitude and no difference in fT3 level is detected in population studied at high altitudes. DOI: http://dx.doi.org/10.3126/kumj.v11i1.11017 Kathmandu University Medical Journal Vol.11(1) 2013: 18-21

Effects of Age and Health on the Euthyroid Reference Ranges for Serum Free Thyroxine and Free Triiodothyronine

1985 ◽  
Vol 24 (02) ◽  
pp. 57-65 ◽  
Author(s):  
J. E. M. Midgley ◽  
K. R. Gruner
Keyword(s):  
Lower Limit ◽  
Healthy Subjects ◽  
Thyroid Dysfunction ◽  
Reference Range ◽  
Free Thyroxine ◽  
Reference Ranges ◽  
Free Triiodothyronine ◽  
Serum Free ◽  
Young Subjects ◽  
Age Range

SummaryAge-related trends in serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations were measured in 7248 euthyroid subjects (age-range 3 months to 106 years). 5700 were patients referred to hospitals for investigation of suspected thyroid dysfunction, but who were diagnosed euthyroid. 1548 were healthy blood donors (age-range 18-63 years) with no indication of thyroid dysfunction. FT4 concentrations were little affected by the age, the sex or the state of health of the subjects in either group. Serum FT3 concentrations were significantly affected by both age and health factors. The upper limit of the euthyroid reference range for young subjects up to 15 years was about 20% higher (10.4 pmol/1) than for adult subjects older than 25 years (8.8 pmol/1). The change in the upper limits typical of young subjects to that typical of adults occurred steadily over the decade 15–25 years. After this age, little further change occurred, especially in healthy subjects. Additionally, the lower limit of the euthyroid range for FT3 was extended by the inclusion in the reference group of patients referred to hospitals. Compared with the lower limit of the FT3 range for healthy subjects (5 pmol/1), the corresponding limit for referred subjects (young or adult) was 3.5–3.8 pmol/1. Broadening of the FT3 reference range was probably brought about by a significant number of patients in the hospital-referred group with the “1OW-T3 syndrome” of mild non-thyroidal illness. Accordingly, FT3 was inferior to FT4 in the discrimination of hypothyroidism, as FT4 was unaffected by this phenomenon. Effects of age and non-thyroidal illness on serum FT3 concentrations require great care when selecting subjects for a laboratory euthyroid reference range typical of the routine workload. Constraints on the choice of subjects for FT4 reference ranges are less stringent.

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