scholarly journals Correlation between Lymphocyte CD4 Count, Treatment Duration, Opportunistic Infection and Cognitive Function in Human Immunodeficiency Virus-Acquired Immunodeficiency Syndrome (HIV-AIDS) Patients

2018 ◽  
Vol 6 (4) ◽  
pp. 643-647 ◽  
Author(s):  
Fasihah Irfani Fitri ◽  
Aldy Safruddin Rambe ◽  
Aida Fitri
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cognitive Function ◽  
Opportunistic Infections ◽  
Cross Sectional Study ◽  
Cd4 Count ◽  
Aids Patients ◽  
Cross Sectional ◽  
Immunodeficiency Virus ◽  
Cd4 Lymphocyte ◽  
Hiv Aids

BACKGROUND: Human immunodeficiency virus (HIV) infection is an epidemic worldwide, despite the marked benefits of antiretroviral therapy (ARV) in reducing severe HIV-associated dementia. A milder form of neurocognitive disorders are still prevalent and remain a challenge.AIM: This study aimed to determine the correlation between plasma cluster of differentiation 4 (CD4) lymphocyte, duration of ARV treatment, opportunistic infections, and cognitive function in HIV-AIDS patients.METHODS: A cross-sectional study involving 85 HIV-AIDS patients was conducted at Adam Malik General Hospital Medan, Indonesia. All subjects were subjected to physical, neurologic examination and Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) to assess cognitive function and measurement of lymphocyte CD4 counts.RESULTS: Out of the 85 subjects evaluated, the proportion concerning sexes include 52 males (61.2 %) and 33 females (38.8%). The mean age was 38.53 ± 9.77 years old. There was a significant correlation between CD4 lymphocyte counts and MoCA-INA score (r = 0.271, p = 0.012), but there was no significant correlation between duration of ARV treatment and MoCA-INA score. There was also no difference in MoCA-INA score based on the presence of opportunistic infection.CONCLUSION: Lymphocyte CD4 count was independently correlated with cognitive function in HIV-AIDS patients.

scholarly journals SAT0078 SAFETY OF LOW DOSE METHOTREXATE (MTX) IN HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 974.2-974
Author(s):  
A. Gunay ◽  
A. Davidson ◽  
I. Colmegna ◽  
D. Lacaille ◽  
H. Loewen ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Adverse Events ◽  
Low Dose ◽  
Opportunistic Infections ◽  
Case Reports ◽  
Cross Sectional Study ◽  
Study Quality ◽  
Sectional Study ◽  
Cross Sectional ◽  
Immunodeficiency Virus

Background:Increased awareness of the efficacy of MTX in rheumatic disease is leading to more MTX use in patients from HIV endemic areas. While HIV related immunosuppression may contribute to improvement of some rheumatic diseases, immune reconstitution from highly active antiretroviral therapy (HAART) may lead to exacerbation or presentation of autoimmune disorders for which MTX therapy may be warranted. Most management guidelines for rheumatic disease do not address MTX use in the context of HIV.Objectives:To systematically review the published literature on the safety of using MTX ≤30 mg per week in HIV.Methods:We searched CINAHL, Embase, Global, MEDLINE and World of Science databases (Jan 1990 to May 2018) for terms including ‘methotrexate’ and ‘human immunodeficiency virus’. We also searched citations from review articles. Titles, abstracts or full manuscripts were screened independently by 2 reviewers to identify studies reporting HIV in patients taking MTX. Study quality was assessed using the McGill Mixed Methods Appraisal Tool (MMAT). Data was extracted on MTX and HIV adverse events (MTX toxicity, HIV viral load, CD4 count). Descriptive summaries are presented for studies providing outcomes in patients taking MTX ≤30 mg per week.Results:After removing duplicates and studies not meeting criteria or not providing sufficient information, 42 of the 2714 identified reports were included (1 clinical trial, 2 cohort, 1 cross-sectional study, 38 case reports/case series). Most reports (81%) originated from USA or Europe. Study quality was generally good with most studies fulfilling 50-100% of MMAT criteria. The randomized controlled trial (USA) assessing MTX on atherosclerotic disease in HIV showed that adverse events were more common in MTX versus placebo (12.8% vs 5.6%, p non-inferiority <0.05) and included infection, transient CD4 and CD8 drop, pulmonary toxicity, and death (1 attributed to MTX/HIV, 1 unrelated). One cohort study (South Africa) reported 43 RA patients on MTX who acquired HIV. In this cohort, RA generally improved despite only 5 individuals continuing MTX. No data on MTX adverse event rates was reported. One cohort study (USA) reported 13 HIV patients with myositis. One received MTX (with other immunosuppression) without MTX adverse effects but died due to AIDS. A cross-sectional study (France) of 43 HIV pts with autoimmune disease reported one patient on MTX (and other immunosuppression) developed an adverse event (cytopenia) compared to 5/33 patients not on MTX (cytopenia). The 38 case reports/series described 54 individuals with HIV receiving MTX. Of these studies, 27 (describing 42 subjects) reported on MTX adverse events and 35 (describing 46 subjects) reported on HIV adverse events. MTX adverse events developed in 29 subjects (hematologic 13, renal/hepatic 1, opportunistic infections 10, other events 2). HIV adverse events were noted in 23 subjects (Kaposi’s sarcoma 4, CD4 decrease 16, HIV viral titer increase 4). Five deaths were reported (2 infection, 1 infection and wasting, 2 HIV related deaths). Most subjects also received corticosteroids or other immunosuppressants including biologics.Conclusion:There remains limited data on the safety of low dose MTX in HIV. Surveillance for HIV is warranted for individuals on MTX who are at risk for acquiring HIV. Caution and careful monitoring for MTX toxicity, opportunistic infections and HIV state is suggested if MTX is used in the setting of HIV particularly if combined with other immunosuppression.References:[1] Clin Infectious Disease 2019:68[2] J Rheumatology 2014:41[3] Arthritis and Rheumatism 2003:49[4] Medicine 2017:96Acknowledgments :Funding from International League Against RheumatismMcGill University Global Health Scholar AwardsDisclosure of Interests:Alize Gunay: None declared, Anna Davidson: None declared, Ines Colmegna: None declared, Diane Lacaille: None declared, Hal Loewen: None declared, Michele Meltzer: None declared, Yewondwossen Mengistu: None declared, Rosie Scuccimarri: None declared, Zenebe Yirsaw: None declared, Sasha Bernatsky: None declared, Carol Hitchon Grant/research support from: UCB Canada; Pfizer Canada

scholarly journals Opportunistic Infections and Associated Factors among HIV/AIDS Patients taking Ante-Retroviral Therapy at Selected Hospitals in Sidama Zone, Southern Ethiopia: A facility-based cross-sectional study

2019 ◽  
Author(s):  
Demelash Wachamo ◽  
Fisseha Bonja
Keyword(s):  
Associated Factors ◽  
Opportunistic Infections ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
High Morbidity ◽  
Major Public Health Problem ◽  
Sectional Study ◽  
Aids Patients ◽  
Cross Sectional ◽  
Hiv Aids

Abstract Background Opportunistic infections are late complications of HIV infection is the depletion of the immune system. It is a major public health problem and high morbidity AIDS patients die of AIDS-related infections in developing countries like Ethiopia. Identification of opportunistic infections (OIs) is important to develop a specific intervention. Therefore, this study aimed to assess the burden and associated factors of opportunistic infections.Method A facility-based cross-sectional study was conducted on 420 randomly selected HIV/AIDS patients taking anti-retroviral therapy. Data was collected from selected hospitals in Sidama Zone based on population proportion to size. Data was collected by a pre-tested questionnaire and a pre-tested checklist from the medical records of patients. Data entry and analyzed for descriptive and logistic regression models by SPSS v.23. The result declared as statistically significant at p < 0.05.Result The magnitude of opportunistic infections was 39.6%. Major identified OIs was oral candidacies 23.2%, recurrent bacterial pneumonia 21.5%, Herpes zoster 6.3%, and Pulmonary Tuberculosis 6.0%.The magnitude of opportunistic associated with; older age [AOR=2.69, 95% CI: 1.33-5.43], No formal education [AOR=3.12, 95% CI: 1.06-9.25], Low monthly income [AOR=2.27, 95%CI:1.35-3.83], initial CD4 count less than 200 cells/mm3 [AOR=1.91, 95% CI:1.05-3.46), WHO clinical stage II [AOR=2.43, 95% CI:1.34-4.42] and stage III and IV [AOR=4.27, 95% CI: 2.12-8.59], had no extra medicine additional to ART (prophylaxis) had [AOR= 5.91, 95% CI: 3.31-10.56], who interrupt ART medicines [AOR=2.03, 95% CI: 1.09- 3.80] and Khat chewing [AOR=5.48, 95% CI: 2.32-12.96] when compared to their counterparts.Conclusions The overall magnitude of opportunistic infections was high when compared with other studies. Health officials and clinicians need to give attention on the strengthening of the provision if ART with prophylaxis on early-stage and adhrerence, implementation of the TB/HIV collaboration activity, and early initiation of ART to reduce opportunistic infections.

scholarly journals Renal Echogenicity as a Predictor of Human Immunodeficiency Virus–Associated Nephropathy: A Cross-Sectional Study at a Tertiary Hospital in Lagos, Southwest Nigeria

2018 ◽  
Vol 34 (4) ◽  
pp. 261-272
Author(s):  
Cletus Uche Eze ◽  
Charles Ugwoke Eze ◽  
Adekunle A. O. Adeyomoye
Keyword(s):  
Human Immunodeficiency Virus ◽  
Serum Creatinine ◽  
Area Under The Curve ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Cd4 Count ◽  
Cross Sectional ◽  
Immunodeficiency Virus ◽  
Southwest Nigeria ◽  
Grade 3

The objective of this study was to determine the accuracy of sonography in a human immunodeficiency virus–associated nephropathy (HIVAN) diagnosis. A sample of 340 HIVAN patients underwent laboratory CD4+ count, serum creatinine/glomerular filtration rate (GFR) estimation, and sonographic echogenicity grading. The accuracy of sonography in predicting an HIVAN diagnosis was calculated. Mean CD4+ count, serum creatinine, and GFR for male and female HIVAN patients was 153.1 ± 103.2 cells/mm3 and 121.9 ± 91.0 cells/mm3, 218.4 ± 147.4 mmol/L and 222.0 ± 150.4 mmol/L, and 50.1 ± 23.6 mL/min/1.73 m2 and 39.3 ± 20.6 mL/min/1.73 m2, respectively; 56.9% of patients had echogenicity grade 3. On the basis of CD4+ count, serum creatinine, and GFR, the area under the curve was 0.76 and ≈ 1, respectively; the area under the curve was 0.63, 0.79, 0.70, 0.79 and 0.91, 0.99, 1, 1 for grades 0, 1, 2, and 3 echogenicity, respectively. With a high level of apathy to voluntary HIV/AIDS screening and late patient presentation, sonography (grade 3 renal echogenicity) can assist in predicting an HIVAN diagnosis.

scholarly journals Loneliness in Older Black Adults with Human Immunodeficiency Virus Is Associated with Poorer Cognition

Gerontology ◽  
2017 ◽  
Vol 63 (3) ◽  
pp. 253-262 ◽  
Author(s):  
S. Duke Han ◽  
Oluwatoyin Adeyemi ◽  
Robert S. Wilson ◽  
Sue Leurgans ◽  
Antonio Jimenez ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Standard Deviation ◽  
Cognitive Function ◽  
Cross Sectional Study ◽  
Self Report ◽  
Inverse Association ◽  
Black Adults ◽  
Cross Sectional ◽  
Immunodeficiency Virus ◽  
White Adults

Background: The human immunodeficiency virus (HIV) is associated with cognitive impairment, and loneliness is associated with cognitive decline in old age. Older Black adults with HIV may be at particular risk of loneliness due to stigma and lack of social resources. Objective: We tested the hypotheses that (1) older Black adults with HIV would show greater loneliness than older White adults with HIV, and (2) greater loneliness among older Black adults with HIV would be associated with poorer cognitive function. Methods: A total of 370 participants (177 with HIV, 193 without HIV; mean age 58.8 years, standard deviation 6.2 years; mean education 13.4 years, standard deviation 2.9 years; 73.9% male, 68.9% Black) in a community-based cross-sectional study of the Rush Center of Excellence on Disparities in HIV and Aging (CEDHA) completed a 5-item self-report scale used to measure emotional loneliness and a battery of cognitive measures. Results: Contrary to our expectations, older Black adults indicated less overall loneliness than White adults (β = -0.3893, SE = 0.1466, p = 0.0087) in models controlling for the effects of age, education, sex, global cognition, and income. However, in models with cognitive function as the outcome, an interaction between race and loneliness was observed, such that older Black adults who indicated greater loneliness showed poorer cognitive function relative to White adults (β = -0.2736, SE = 0.1138, p = 0.0174). Conclusion: Older Black adults with HIV reported less loneliness than older White adults; however, the inverse association between loneliness and cognitive function was stronger in Black than White older adults. Additional work is needed to elucidate the mechanisms underlying this interaction.

scholarly journals Sonographic detection of abdominal pathologies in human immunodeficiency virus/acquired immunodeficiency syndrome patients and its correlation with CD4 counts – A prospective analysis

2020 ◽  
Vol 0 ◽  
pp. 1-8
Author(s):  
Tejas Kanthrao Mankeshwar ◽  
Ashok Kumar Sharma
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lymph Nodes ◽  
Acquired Immunodeficiency Syndrome ◽  
Cd4 Count ◽  
Aids Patients ◽  
Cd4 Counts ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

Objectives: Abdominal pathologies are the second most common after pulmonary diseases in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. Ultrasonography (USG) is a vital imaging technique for the evaluation of abdominal pathologies. This study was aimed at evaluating the abdominal pathologies using USG in HIV/AIDS and further analysis of its correlation with CD4 count. Material and Methods: The present study was carried out on 392 HIV-positive patients with abnormal abdominal sonographic findings. All data were analyzed by Chi-square test and one-way analysis of variance using SPSS 16.0 software. Results: Of these 392 patients, 66.3% were males, the mean age was 35.7 years, (range 7–64 years) and most of them were in 4th decade. On ultrasonographic evaluation, spleen was involved in 45.2% patients and liver as well as lymph nodes each was involved in 43.6% patients. Other cases displayed ascites and bowel thickening in 5.3% and 3.8% patients, respectively. Less involvement of kidney (2.3%), pancreas (1.5%), and biliary system (1.3%) was observed. In addition, pathologies such as hepatomegaly, splenomegaly, splenic microabscess, focal pancreatic lesion, mesenteric, and periportal lymphadenopathy showed significant correlation with CD4 counts. Lymphoma was found in 1% of patients, involving liver, pancreas, and retroperitoneal lymph nodes. Conclusion: Our study highlights the clinical utility of abdominal USG in HIV/AIDS patients. CD4 counts largely affect the differential diagnosis in HIV/AIDS patients. USG findings interpreted in the context of CD4 count may help in guiding the exact diagnosis.

Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55–70 Study

2019 ◽  
Vol 70 (12) ◽  
pp. 2641-2648 ◽  
Author(s):  
Alain Makinson ◽  
Jonathan Dubois ◽  
Sabrina Eymard-Duvernay ◽  
Pascale Leclercq ◽  
Olivia Zaegel-Faucher ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cross Sectional Study ◽  
Neurocognitive Impairment ◽  
Hiv Viral Load ◽  
Cross Sectional ◽  
Increased Risk ◽  
Immunodeficiency Virus ◽  
Cd4 Lymphocyte ◽  
Matched Study ◽  
Aging People

Abstract Background There are limited data on the comparative prevalence of neurocognitive impairment (NCI) in aging people living with human immunodeficiency virus (PLHIV) and people not living with HIV. Methods This was a cross-sectional study of PLHIV randomly matched by age (±4 years), gender, and education with 5 HIV-uninfected individuals from the CONSTANCES cohort. PLHIV were fluent in French and sequentially included during routine outpatient visits if aged 55–70 years, with HIV viral load &lt;50 copies/mL, and lymphocyte T-CD4 level ≥200 cells/µL in the past 24 and 12 months, respectively. The primary outcome was NCI as defined by the Frascati criteria. Multivariate normative comparison (MNC) and −1.5 standard deviations in ≥2 neurocognitive domains were secondary outcomes of NCI. Results Two hundred PLHIV were matched with 1000 controls. Median age was 62 years, and 85% were men. In PLHIV, the median T-CD4 lymphocyte level was 650 cells/µL, and median nadir T-CD4 lymphocyte level was 176 cells/µL. NCI was found in 71 (35.5%) PLHIV and in 242 (24.2%) controls (odds ratio [OR], 1.74; 95% confidence interval [CI], 1.25, 2.41). After adjusting for confounders, HIV remained significantly associated with NCI (OR, 1.50; 95% CI, 1.04, 2.16). Adjusted results were similar with NCI defined by MNC (ORMNC, 2.95; 95% CI, 1.13, 3.50) or −1.5 SD (OR−1.5, 2.24; 95% CI, 1.39, 3.62). Conclusions In this matched study of aging individuals, HIV was significantly associated with an increased risk of NCI after adjusting for major confounders. Results were confirmed with more stringent NCI classifications. Clinical Trials Registration NCT02592174.

scholarly journals The Lipid Profile of Human Immunodeficiency Virus-infected Patients Receiving Antiretroviral Therapy at Mpilo Central Hospital Opportunistic Infections Clinic

2019 ◽  
pp. 1-10
Author(s):  
N. Maunga ◽  
E. Zumbika ◽  
K. Mhandire ◽  
F. F. Chikuse ◽  
G. A. Mavondo
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Blood Lipids ◽  
Opportunistic Infections ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Central Hospital ◽  
Cross Sectional ◽  
Immunodeficiency Virus ◽  
Mpilo Central Hospital

Aims: Long term use of antiretroviral therapy subpopulation living with human immunodeficiency virus is associated with disturbances in blood lipids profiles which are not routinely monitored. More data on such disturbances are needed to persuade the country’s program to institute routine monitoring. This study sought to determine the prevalence and timing of dyslipidaemia in HIV/AIDS naïve people on ART at in Zimbabwe. Place and Duration of Study: The study was conducted at Mpilo Central Hospital Opportunistic Infections Clinic in Bulawayo, Zimbabwe over a period of three months. Methods: A cross-sectional study was conducted in HIV-infected persons receiving highly active anti-retroviral treatment at Mpilo Central Hospital Opportunistic Infections Clinic. Lipid assays were determined by Elisa methods. Viral loads and CD4 were measured using the COBAS® TaqMan® and BD FACSCount™ Flow Cytometer, respectively. Results: A total of 149 consenting participants were enrolled and most (63.2%) were females. The median age of the respondents was 43 years and their median CD4 count was 436 cells/μl after a median duration on ART of 36 months. Viral load was <40 in the majority (68.6%) of the participants. More females (63.1%) were on HAART and were aged >35 (60.4%) years. NNRTI (90.6%) were the more commonly prescribed HAART. The prevalence of dyslipidaemia was 70.2%. Hypercholesterolaemia was observed in 72 (48.3%) patients with 26 being male and 46 being female. High levels of LDL-cholesterol (LDL-c ≥ 3.0 mmol/L) were found in 115 patients with 74 of them being female. Hypertriacylglycerolaemia (TAG ≥ 2.0 mmol/L) was present in 8 cases. The proportion of patients with a low HDL-cholesterol (HDL-c < 1.0 mmol/L) was 15.3% while those with a ratio of TC/HDL-c ≥ 4.1 were 87.5%. Conclusion: The study demonstrated a high prevalence of dyslipidaemia in HIV-patients receiving HAART. There is a need for the Country’s HIV program to institute laboratory monitoring of blood lipids in patients over one year on HAART.

scholarly journals Social Support and Depression in Patients with Human Immunodeficiency Virus Attending a General Hospital in South-South,Nigeria

2021 ◽  
Vol 6 (1) ◽  
Keyword(s):  
Social Support ◽  
Human Immunodeficiency Virus ◽  
General Hospital ◽  
Cross Sectional Study ◽  
Health Issues ◽  
Cross Sectional ◽  
Immunodeficiency Virus ◽  
Received Social Support ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

Background: Depression is one of the commonest psychiatric disorders seen among Human immunodeficiency virus/Acquired immunodeficiency syndrome (HIV/AIDS) individuals and these two conditions are significant public health issues. Also, lack of social support increases the risk of depression among them. Aim: To determine the extent and type of social support and correlates of depression among HIV/AIDS patients attending General Hospital in south-south, Nigeria. Setting: The research was conducted in the HIV/AIDS outpatient clinic of the General hospital in south-south, Nigeria. Methods: A cross-sectional study design was carried out on three hundred and twenty-three patients living with HIV/AIDS from June to October 2016. The instruments used were Socio-demographic questionnaire, Mini international neuropsychiatric interview M.I.N.I (A1-A6 module, English version 6.0), and OSLO-3 items social support scale. Results: Majority (95.7%) of the respondents received social support and more than half (53.6%) of the respondents have strong social support. There was a significant association between social support and depression (X2 =18.38, df =1, p=0.001). The majority (83.3%) of the respondents were females and depression was significantly associated with marital status (X2=7.36, df=2, p=0.03).Also, there was a significant association between monthly income and depression(X2=9.31, df=2, p=0.01). In multivariate regression, absence of social support (B=2.120, p=0.001, OR=8.327) was the most significant predictor for depression Conclusion: This finding implies that depression is one of the mental health issues that affect HIV/AIDS infected individuals in Nigeria and lack of social support increases the risk of depression among them.

scholarly journals ANGKA KEJADIAN KOMPLIKASI INTRAKRANIAL PADA PENDERITA HIV/AIDS YANG DI RAWAT INAP DI BAGIAN NEUROLOGI RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JULI 2012 – JUNI 2013

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Christy B Tumbelaka
Keyword(s):  
Human Immunodeficiency Virus ◽  
Tuberculous Meningitis ◽  
Acquired Immunodeficiency Syndrome ◽  
Opportunistic Infections ◽  
Aids Patients ◽  
Intracranial Complication ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

Abstract: Human Immunodeficiency Virus (HIV) is virus that causes Acquired Immunodeficiency Syndrome (AIDS), which is a retrovirus disease that characterized by the severe immunosuppression that cause opportunistic infection, secondary neoplasm and neurologic manifestations. Nervous system involvement in HIV infections may occur directly through the virus and indirectly as a result of opportunistic infections due to immunocompromised. This study aimed to determine the incidence of intracranial complication in HIV/AIDS patients who were hospitalized in Neurology Ward of RSUP Prof. Dr. R. D. Kandou Manado from July 2012 to June 2013. This study were a retrospective descriptive study using medical record of patients with HIV/AIDS. The results showed there were 36 patients with HIV/AIDS and 27 patients had intracranial complications. Tuberculous Meningitis was the most common type of complications with percentage (51,9%). Based on those 27 HIV/AIDS patients with intracranial complication, patients who were 25-34 years old (44%) have the most intracranial complication. Based on the gender percentage, it is dominated by male (59,3%) and based on the occupations, it is commonly came from entrepreneurs (29,6%). Conclusion: The incidences of intracranial complication in patients with HIV/AIDS were quite high on Tuberculous Meningitis, and it is dominated by male. The highest distributions were found on aged 25-34 whose occupation were entrepreneurs. Keywords: Intracranial Complication, HIV/AIDS, patients.   Abstrak: Human Immunodeficiency Virus (HIV) merupakan virus yang menyebabkan penyakit Acquired Immunodeficiency Syndrome (AIDS) yaitu suatu penyakit retrovirus yang ditandai dengan imunosupresi berat yang menimbulkan infeksi oportunistik, neoplasma sekunder, dan manifestasi neurologis. Keterlibatan sistem saraf pada infeksi HIV dapat terjadi secara langsung karena virus tersebut dan tidak langsung akibat infeksi oportunistik akibat imunokompromis. Penelitian ini bertujuan untuk mengetahui angka kejadian komplikasi intrakranial pada penderita HIV/AIDS yang di rawat inap di Bagian Neurologi RSUP Prof. Dr. R. D. Kandou Manado selama periode Juli 2012 – Juni 2013. Metode penelitian ini ialah deskriptif retrospektif dengan menggunakan catatan rekam medik penderita HIV/AIDS. Hasil peneitian memperlihatkan dari 36 pasien HIV/AIDS, terdapat 27 penderita yang memiliki komplikasi intrakranial dengan persentase jenis komplikasi intrakranial terbanyak yaitu Meningitis Tuberkulosis (51,9%). Dari 27 penderita HIV/AIDS yang memiliki komplikasi intrakranial paling banyak ialah pada kelompok umur 25-34 tahun (44,4%) sedangkan untuk jenis kelamin, didominasi oleh penderita berjenis kelamin laki-laki (59,3%), dan jenis pekerjaan terbanyak ialah wiraswasta (29,6%). Kesimpulan: Angka kejadian komplikasi intrakranial pada penderita HIV/AIDS yang cukup tinggi terdapat pada Meningitis Tuberkulosis dengan jenis kelamin terbanyak ialah laki-laki. Distribusi yang cukup tinggi pula ditemukan pada kelompok umur 25-34 tahun dengan jenis pekerjaan sebagai wiraswasta. Kata Kunci: Komplikasi Intrakranial, HIV/AIDS, penderita

scholarly journals FAKTOR YANG BERHUBUNGAN LAMA HIDUP PADA ODHA SETELAH 10 TAHUN DENGAN HIV/AIDS

2018 ◽  
Vol 6 (1) ◽  
pp. 128
Author(s):  
Rokhani Rokhani ◽  
Mustofa Mustofa
Keyword(s):  
Immune Deficiency ◽  
Human Immunodeficiency Virus ◽  
Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Cross Sectional Study ◽  
Study Data ◽  
Sectional Study ◽  
Cross Sectional ◽  
Immunodeficiency Virus ◽  
Hiv Aids

Orang dengan infeksi HIV (Human Immunodeficiency Virus) akan mengalami penurunan sistem imunitas pada tubuhnya, kondisi ini akan menyebabkan kondisi kesehatan semakin menurun hingga akan memunculkan berbagai macam gangguan kesehatan seperti infeksi oportunistik dan menurunnya berat badan hingga menjadi AIDS (Aquired Immune Deficiency Syndrome). Tujuan penelitian ini adalah untuk mendiskripsikan titer virus yang dimiliki oleh pasien, dan mendiskripsikan kondisi kesehatan pasien serta karakteristik yang dimiliki pasien setelah terinfeksi oleh HIV selama 10 tahun. Penelitian ini menggunakan explanatory research dengan pendekatan cross-sectional study. Data diperoleh dengan teknik wawancara terpimpin pada 80 pasien yang terinfeksi HIV yang dianalisa dengan univariat menggunakan distribusi frequensi dan analisa bivariat dengan q-square. hasil penelitian menemukan adanya hubungan yang signifikan antara umur, jenis kelamin, kondisi kesehatan dan viral load dengan lama hidup orang dengan HIV/AIDS. Konsumsi ARV, penerimaan terhadap status HIV-nya dan sikap positif dalam meninggalkan perilaku beresiko sangat penting bagi orang yang hidup dengan HIV/AIDS. Kata kunci: Lama Hidup,  ODHA, 10 tahun dengan HIV/AIDS

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