scholarly journals Oxidative Role of Aflatoxin B1 on the Liver of Wheat Milling Workers

2014 ◽  
Vol 2 (1) ◽  
pp. 141-146 ◽  
Author(s):  
Amal Saad-Hussein ◽  
Mohgah Sh. Abdalla ◽  
Wafaa Gh. Shousha ◽  
Gehan Moubarz ◽  
Aya H. Mohamed
Keyword(s):  
Oxidative Stress ◽  
Statistical Analysis ◽  
Vitamin C ◽  
Aflatoxin B1 ◽  
Crucial Role ◽  
Case Control Study ◽  
Liver Enzymes ◽  
Case Control ◽  
Control Study

Aim: The study aimed to estimate oxidative role of aflatoxin B1 (AFB1) on the liver in wheat milling workers. Materials and Methods: Case-control study was conducted to compare between the levels of AFB1/albumin (AFB1/alb), liver enzymes (ALT, AST, GGT, and ALP), P53, MDA, GST, SOD, zinc and vitamin C in 35 wheat milling workers and 40 control subjects. Results: Statistical analysis revealed that ALT, AST, GGT, ALP, P53, MDA, GST and SOD in workers were significantly elevated compared to their controls. In the milling workers, there were significant correlations between MDA levels and the levels of AST, GGT, and P53, while, P53 was inversely correlated with GST and SOD activities. There were significant correlations between Zn levels and GGT, GST and SOD activities, between vitamin C and GST activities, and vitamin C inversely correlated with MDA. Conclusion: The present study concluded that the oxidative stress of AFB1 elevated the MDA and the liver enzymes in wheat milling workers. GST has a crucial role in the detoxification of aflatoxin and SOD as a scavenger antioxidant increased in the workers to overcome the oxidative toxic effects of AFB1 on the liver of the workers, and roles of Zn and vitamin C were significant in activation of these processes.

scholarly journals Glutathione Peroxidase1 Gene Polymorphism (GPx1 Pro198Leu) in Association with Blighted Ovum

2016 ◽  
Author(s):  
Asiyeh Moshtaghi ◽  
Reyhaneh Sariri ◽  
Hamidreza Vaziri ◽  
Horiyeh Shayegan
Keyword(s):  
Statistical Analysis ◽  
Gene Polymorphism ◽  
Genomic Dna ◽  
Obstet Gynecol ◽  
Case Control Study ◽  
Case Control ◽  
Glutathione Peroxidase 1 ◽  
Control Study ◽  
Blighted Ovum

Objective: To evaluate salivary GPx-1 gene polymorphism in pregnant women suffering from blighted ovum. Method: In this case-control study, 34 blighted ovum patients and 34 healthy controls were studied. Genomic DNA was extracted from the saliva. The genotypes were determined by restriction fragment length polymorphism (RFLP-PCR) technique. Mad Calc (version 12.1) was used for statistical analysis. Result: The frequency of CC, CT, and TT genotypes of GPx-1 gene were 41%, 44% and 14%, respectively in blighted ovum patients and in healthy volunteers were 44%, 47%, and 8.82-9%, respectively. After statistical analysis, the study showed no significant association between this polymorphism and blighted ovum (with p = 0.63). Conclusion: These results indicated no significant association between GPx-1 (Pro198Leu) polymorphism and blighted ovum. However, further research is required to clarify the role of gene polymorphism in blighted ovum. [Indones J Obstet Gynecol 2016; 1: 15-18] Keywords: abortion, blighted ovum, glutathione peroxidase-1, GPx- 1, RFLP-PCR

scholarly journals Role of Lipid and Oxidative Stress in Psoriatic Patients - A Case Control Study

2021 ◽  
Vol 10 (3) ◽  
pp. 132-136
Author(s):  
Roshan Kumar Jha ◽  
Akansha Singh ◽  
Priya Koundal ◽  
Ranjit Sidram Ambad
Keyword(s):  
Oxidative Stress ◽  
Case Control Study ◽  
Case Control ◽  
And Oxidative Stress ◽  
Control Study

scholarly journals Oxidative Stress and Polymorphism in MTHFR SNPs (677 and 1298) in Paternal Sperm DNA is Associated with an Increased Risk of Retinoblastoma in Their Children: A Case–Control Study

2018 ◽  
Vol 07 (03) ◽  
pp. 103-113 ◽  
Author(s):  
Shilpa Bisht ◽  
Bhavna Chawla ◽  
Rima Dada
Keyword(s):  
Oxidative Stress ◽  
Case Control Study ◽  
Case Control ◽  
Mthfr Gene ◽  
Nucleotide Polymorphisms ◽  
Mthfr Polymorphisms ◽  
Sperm Dna ◽  
Increased Risk ◽  
Control Study

AbstractSperm DNA is considered as the most vulnerable to oxidative stress-induced damage that also impairs global sperm DNA methylation leading to sperm-associated pathologies. C677T and A1298C polymorphisms of the methylene tetrahydrofolate reductase (MTHFR) gene affect MTHFR enzyme activity. This study was planned as a case–control study to determine the MTHFR gene polymorphisms in the fathers of children affected with sporadic nonfamilial heritable retinoblastoma in an Indian population. MTHFR polymorphisms for single nucleotide polymorphisms 677 and 1298 were also determined in sporadic nonfamilial heritable retinoblastoma patients to estimate the risk for retinoblastoma development and to evaluate the role of MTHFR in retinoblastoma pathogenesis.

scholarly journals S94 The role of oxidative stress and antioxidants in severe asthma; a case control study

Thorax ◽  
2015 ◽  
Vol 70 (Suppl 3) ◽  
pp. A53.2-A54
Author(s):  
A Bishopp ◽  
R Sathyamurthy ◽  
AH Mansur
Keyword(s):  
Oxidative Stress ◽  
Severe Asthma ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Role of antioxidant supplementation in oxidant/antioxidant status and hepatotoxic effects due to aflatoxin B1 in wheat miller workers

2019 ◽  
Vol 16 (4) ◽  
Author(s):  
Amal Saad-Hussein ◽  
Gehan Moubarz ◽  
Sh. Abdalla Mohgah ◽  
Gh. Shousha Wafaa ◽  
H. Mohamed Aya
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Aflatoxin B1 ◽  
Antioxidant Status ◽  
Liver Enzymes ◽  
P53 Protein ◽  
Oral Supplementation ◽  
Group I ◽  
Ameliorative Effect

Abstract Background Aflatoxin B1 (AFB1) is classified as a Group I carcinogen. A Previous study found that oxidative stress from the metabolism of AFB1 induced hepatotoxic effects in wheat miller workers. Zinc and vitamin C may play a significant role in the activation of detoxification and overcoming the oxidative stress of AFB1. Objectives A prospective clinical trial was designed to evaluate the role of zinc and vitamin C oral supplementation on the oxidant-antioxidant status and the hepatotoxic effects of AFB1 in wheat miller workers. Methods Liver enzymes (ALT, AST, ALP, and GGT), P53 protein, malondialdehyde (MDA), glutathione S transferase (GST), Superoxide dismutase (SOD), zinc and vitamin C were estimated in 35 wheat miller workers before and after zinc and vitamin C supplementation for 1 month. Results The results revealed that zinc and vitamin C were significantly increased after the one-month supplementation, while liver enzymes (AST, ALP, and GGT), MDA, and GST of the workers were significantly decreased. SOD and P53 were also decreased but not to a significant level; SOD was decreased in 56% and P53 was decreased in 58% of the total workers. Conclusions Zinc and vitamin C oral supplementation for 1 month had an ameliorative effect on the hepatotoxicity of AFB1 in wheat miller workers, through decreasing MDA, SOD, and GST levels that in turn led to an improvement in their liver enzymes. Further study on a larger scale is needed to confirm these results.

scholarly journals P2-233: The role of hippocampal atrophy for the differentiation between MCI subtypes: Results of a case-control study

2012 ◽  
Vol 8 (4S_Part_9) ◽  
pp. P341-P341
Author(s):  
Martha Dlugaj ◽  
Christoph Mönninghoff ◽  
Hans-Jürgen Huppertz ◽  
Isabel Wanke ◽  
Daniel Jokisch ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Hippocampal Atrophy ◽  
Control Study

scholarly journals Results from an International Case-Control Study of Childhood Brain Tumors: The Role of Prenatal Vitamin Supplementation

1998 ◽  
Vol 106 ◽  
pp. 887 ◽  
Author(s):  
Susan Preston-Martin ◽  
Janice M. Pogoda ◽  
Beth A. Mueller ◽  
Flora Lubin ◽  
Baruch Modan ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Case Control Study ◽  
Case Control ◽  
Vitamin Supplementation ◽  
Childhood Brain Tumors ◽  
Control Study
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