scholarly journals C-reactive protein and Neutrophil-Lymphocyte Ratio as predictors of clinical severity of COVID-19

2021 ◽  
Vol 13 (2) ◽  
pp. 1-14
Author(s):  
Stefan Pandilov ◽  
Suzana Klenkoski ◽  
Elena Jovanovska Janeva ◽  
Gazmend Mehmeti ◽  
Dragan Mijakoski ◽  
...  
Keyword(s):  
Clinical Manifestation ◽  
White Blood Cells ◽  
Clinical Severity ◽  
Bivariate Analysis ◽  
C Reactive Protein ◽  
Lethal Outcome ◽  
Laboratory Parameters ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Markers Of Inflammation

COVID-19 is an infectious disease that can manifest quite differently. In this study we examined the relationship between the value of serum CRP(C-reactive protein) andneutrophil-lymphocyte ratio (NLR) as predictor factors for the development of a severe clinical manifestation in COVID19 patients. Materials and methods: We followed 95 COVID-19 positive patients who were hospitalized at the University Clinic for Eye Diseases - COVID Center. We analyzed the initial laboratory parameters of white blood cells and CRP on admission of the patients and the results of laboratory analyses performed before they left the Clinic, or the last parameters before the lethal outcome in those patients who died. Several models of logistic regression were tested to analyze the predictive value of these markers of inflammation for lethal outcome in patients hospitalized for COVID-19. Results: Bivariate analysis demonstrated that the length of hospital stay was significantly shorter in patients with lethal outcome (p=0.001). The NLR was significantly higher in patients with lethal outcome at both times (p=0.005; and p=0.017). Leukocyte’s count (p=0.046, and p<0.001) and CRP (p=0.013,and p=0.005) were also significantly higher in patients with lethal outcome at both times. The increase on the NLR scale both at hospitalization and at discharge (or the last analysis before death) leads to increase in the odds of lethal outcome (T1:40.4% increased odds; T2:36% increased odds). Conclusion: CRP and NLR are laboratory parameters that can predict the severity of the clinical manifestation in patients with COVID-19.

scholarly journals Diagnostic Accuracy of Procalcitonin, Neutrophil-to-Lymphocyte Ratio, and C-Reactive Protein in Detection of Bacterial Infections and Prediction of Outcome in Nonneutropenic Febrile Patients with Lung Malignancy

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Shanshan Ding ◽  
Jun Ma ◽  
Xingguo Song ◽  
Xiaohan Dong ◽  
Li Xie ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Bacterial Infections ◽  
White Blood Cells ◽  
Neutrophil To Lymphocyte Ratio ◽  
C Reactive Protein ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Retrospective Clinical Study ◽  
The Absolute

Background. Procalcitonin (PCT), C-reactive protein (CRP), and neutrophil-to-lymphocyte ratio (NLR) have emerged as important markers of inflammation, and these markers, especially PCT and CRP, have been studied in patients with neutropenia. This study was designed to evaluate their value in differentiating infectious fever from tumor fever (TF) and to investigate their role in assessing outcomes in nonneutropenic lung cancer patients (NNLCPs). Methods. This retrospective clinical study included 588 febrile NNLCPs between January 2019 and December 2019. The levels of PCT, CRP, and conventional inflammatory markers, including white blood cells (WBC) and neutrophils (NEU), were measured. NLR was defined as the ratio of the absolute neutrophil count to the absolute lymphocyte count. Patients’ clinical and bacteriological data were recorded. Results. This study included 311 NNLCPs with bacterial infections and 277 with TF. Inflammatory markers such as PCT, CRP, WBC, and NEU levels and NLR were significantly higher in patients with bacterial infections than in those with TF (p < 0.0001). However, PCT level was the best predictor of bacterial infections, with an area under the curve (AUC) of 0.874, followed by CRP level (AUC = 0.855) and NLR (AUC = 0.792) (p < 0.0001). Additionally, PCT level was significantly elevated in patients with bacterial infections with progressive disease after radiotherapy and chemotherapy (p < 0.01). Conclusions. The present study demonstrated the superiority of PCT over CRP and NLR in the diagnosis of febrile patients with bacterial infections. Additionally, PCT can be used to assess the clinical outcomes and cancer progression in NNLCPs.

scholarly journals Relationship between the Plasma Concentration of C-Reactive Protein and Severity of Peripheral Arterial Disease

2009 ◽  
Vol 3 ◽  
pp. CMC.S1062 ◽  
Author(s):  
Joaquin De Haro ◽  
Francisco Acin ◽  
Francisco Jose Medina ◽  
Alfonso Lopez-Quintana ◽  
Jose Ramon March
Keyword(s):  
Peripheral Arterial Disease ◽  
Plasma Levels ◽  
Smoking Status ◽  
Arterial Disease ◽  
Clinical Severity ◽  
C Reactive Protein ◽  
Surgical Revascularization ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Peripheral Arterial

Objective To determine whether the increase in plasma levels of C-Reactive Protein (CRP), a non-specific reactant in the acute-phase of systemic inflammation, is associated with clinical severity of peripheral arterial disease (PAD). Methods and Results This is a cross-sectional study at a referral hospital center of institutional practice in Madrid, Spain. A stratified random sampling was done over a population of 3370 patients with symptomatic PAD from the outpatient vascular laboratory database in 2007 in the order of their clinical severity: the first group of patients with mild chronological clinical severity who did not require surgical revascularization, the second group consisted of patients with moderate clinical severity who had only undergone only one surgical revascularization procedure and the third group consisted of patients who were severely affected and had undergone two or more surgical revascularization procedures of the lower extremities in different areas or needed late re-interventions. The Neyman affixation was used to calculate the sample size with a fixed relative error of 0.1. A homogeneity analysis between groups and a unifactorial analysis of comparison of medians for CRP was done. The groups were homogeneous for age, smoking status, Arterial Hypertension HTA, diabetes mellitus, dyslipemia, homocysteinemia and specific markers of inflammation. In the unifactorial analysis of multiple comparisons of medians according to Scheffe, it was observed that the median values of CRP plasma levels were increased in association with higher clinical severity of PAD (3.81 mg/L [2.14-5.48] vs. 8.33 [4.38-9.19] vs. 12.83 [9.5-14.16]; p < 0.05) as a unique factor of tested ones. Conclusion Plasma levels of CRP are associated with not only the presence of atherosclerosis but also with its chronological clinical severity.

The correlation between the concentration of faecal calprotectin and markers of inflammation in children with gastrointestinal disorders

2017 ◽  
Vol 53 (2) ◽  
pp. 91-96
Author(s):  
Katarzyna Lewandowska ◽  
Olga Ciepiela
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Intestinal Inflammation ◽  
White Blood Cells ◽  
Intestinal Lumen ◽  
C Reactive Protein ◽  
Faecal Calprotectin ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Erythrocyte Sedimentation

Introduction: Calprotectin is an acute phase protein that occurs in large amounts in the granules and cytosolic fluid of neutrophils, and in smaller amounts in monocytes and macrophages. In bowel inflammation, increased neutrophil migration from the circulation to the intestinal lumen is observed as a consequence of mucosal damage. This leads to the release of a significant amount of calprotectin by activated leukocytes in intestine, thereby increasing its concentration in the faeces. This allows the non-invasive assessment of intestinal inflammation. Other markers useful in patients with bowel inflammation are erythrocyte sedimentation rate and C-reactive protein. Aim: The aim of the study was to evaluate the correlation between the concentration of faecal calprotectin (FC) and other markers of inflammation, such as C-reactive protein (CRP) and ferritin in serum, erythrocyte sedimentation rate (ESR) and white blood cells (WBC) count and in children with Crohn’s disease and ulcerative colitis. Material and methods: This study is based on a retrospective analysis of laboratory results of 370 children suspected of inflammatory bowel disease (IBD). Pearson’s coefficient was used to assess the correlation between the parameters. Results: There was a positive correlation between concentration of FC and parameters such as CRP (r=0.16; p=0.0345), ESR (r=0.38; p<0.0001) and WBC (r=0.24; p=0.0008) in children with IBD. There was also a negative correlation between concentration of FC and ferritin (r=-0.24; p=0.0089) in children with IBD. Conclusion: In this study, ESR turned out to be more adequate than CRP and WBC in detecting inflammation in patients with IBD.

scholarly journals PENILAIAN JUMLAH NEUTROFIL, LIMFOSIT DAN TROMBOSIT, KADAR PROTEIN REAKTIF C, KADAR ALBUMIN, RASIO NEUTROFIL LIMFOSIT, SERTA RASIO TROMBOSIT LIMFOSIT SEBELUM DAN SETELAH TERAPI PADA PENDERITA KARSINOMA PAYUDARA

2015 ◽  
Vol 7 (3) ◽  
Author(s):  
Benny Hartono ◽  
Victor S. Pontoh ◽  
Marselus A. Merung
Keyword(s):  
Breast Carcinoma ◽  
Stage Iv ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Stadium Iv ◽  
Markers Of Inflammation ◽  
Before And After

Abstract: Breast carcinoma is a type of carcinoma that has sufficiently high prevalence and can occur in men and women, with a much higher prevalence in women. In addition to the high number of cases, more than 70% of patients with breast carcinoma was found at an advanced stage. There are several studies measuring markers of inflammation and the levels of albumin in the search for an independent prognostic association in various carcinomas. The ratio of neutrophils to lymphocytes, ratio of platelets to lymphocyte, C-reactive protein, and albumin are predictors in analyzing the changes that occur before and after treatment (chemotherapy and/or surgery) in patients with breast carcinoma. This was an interventional analytical study with a cross-sectional design, conducted in Prof. Dr. R. D. Kandou Hospital Manado during the period of May 2014 to April 2015. The results showed that there were 43 females with breast carcinoma with an average age of 52.16 years. The state dof carcinoma were as follows: stage IIIA 5 patients (11.6%), IIIB 25 patients (58.1%), IIIC 11 patients (25.6%), and stage IV 2 patients (4.7%). Modality of chemotherapy plus surgery was performed on 40 patients (93%), chemotherapy only on 2 patients (4.7 %), and surgery only on 1 patient (2.3%). Among the treated patients there were significant declines in the value of neutrophils, platelets, C-reactive protein, neutrophil lymphocyte ratio, and platelet lymphocyte ratio, moreover, there were significant inclines in lymphocytes and albumin. Conclusion: Modality of chemotherapy and/or surgery in patients with breast carcinoma significantly affected the haemopoetic process (declines of neutrophil and platelet counts, NLR and TLR values), declined CRP levels, but inclined lymphocyte count as well as albumin levels when compared before and after treatment.Keywords: breast carcinoma, C-reactive protein, albumin, neutrophil lymphocyte ratio, thrombocyte lymphocyte ratioAbstrak: Karsinoma payudara (KPD) merupakan salah satu jenis karsinoma yang memiliki prevalensi cukup tinggi dan dapat terjadi pada pria maupun wanita, dengan prevalensi yang jauh lebih tinggi pada wanita. Selain jumlah kasus yang tinggi, lebih dari 70% penderita KPD ditemukan pada stadium lanjut. Terdapat beberapa penelitian mengukur petanda peradangan dan kadar albumin dalam mencari kaitan prognostik independen pada berbagai karsinoma. Rasio neutrofil limfosit, rasio trombosit limfosit, protein reaktif C, dan albumin menjadi prediktor dalam menganalisis perubahan yang terjadi sebelum dan setelah terapi (kemoterapi dan/atau operasi) pada pasien KPD. Penelitian ini merupakan penelitian intervensional analitik dengan desain potong lintang, yang dilakukan di RSUP Prof. Dr. R. D. Kandou Manado selama periode Mei 2014 - April 2015. Hasil penelitian mendapatkan 43 pasien KPD yangdirawat dengan usia rata-rata 52,16 tahun. Keadaan karsinoma stadium IIIA pada 5 pasien (11,6%), IIIB 25 pasien (58,1%), IIIC 11 pasien (25,6%), dan stadium IV 2 pasien (4,7%). Pemberian modalitas kemoterapi dan operasi pada 40 pasien (93%), hanya kemoterapi 2 pasien (4,7%), dan hanya operasi 1 pasien (2,3%). Terjadi penurunan bermakna pada nilai hitung neutrofil dan trombosit, protein reaktif C, rasio neutrofil limfosit dan rasio trombosit limfosit pada pasien yang diterapi. Selain itu terjadi peningkatan bermakna pada nilai hitung limfosit dan albumin. Simpulan Tindakan yang diberikan baik kemoterapi dan/atau operasi pada pasien karsinoma payudara memengaruhi proses hemopoetik (penurunan hitung neutrofil, trombosit, nilai NLR, nilai TLR) dan penurunan kadar CRP, serta peningkatan limfosit dan kadar albumin saat dibandingkan sebelum dan setelah diberikan perlakuan.Kata kunci: karsinoma payudara, protein reaktif C, albumin, rasio neutrofil limfosit, rasio trombosit limfosit

scholarly journals Systemic inflammatory markers and serum lactate dehydrogenase predict survival in patients with Wilms tumour

2021 ◽  
Author(s):  
Michał Kunc ◽  
Anna Gabrych ◽  
Dominika Dulak ◽  
Hasko Karolina ◽  
Malgorzata Styczewska ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Prognostic Value ◽  
Serum Lactate Dehydrogenase ◽  
Study Group ◽  
Wilms Tumour ◽  
C Reactive Protein ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Paediatric Patients

IntroductionThe markers of inflammation such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) have been found associated with survival in cancer patients. The aim of the current study was to establish the prognostic significance of simple laboratory markers of systemic inflammation in paediatric patients diagnosed with Wilms tumour. Additionally, we aimed to compare the CBC parameters of WT patients and the non-oncological control group.Material and methodsThe study group included 83 children diagnosed with WT. Clinicopathological data, as well as complete blood count (CBC), C-reactive protein (CRP) and lactate dehydrogenase (LDH) levels at diagnosis, were obtained. Additionally, the laboratory results of healthy 63 control paediatric patients were collected. Uni- and multivariate proportional Cox’s hazard analyses were computed to create a model predicting relapse-free survival (RFS) and overall survival (OS) in the study group.ResultsHigh CRP, LDH, and NLR were associated with a higher stage of WT and shorter RFS; whereas all parameters correlated with OS. In multivariate analysis, only LDH levels had adverse significance in predicting RFS. C-reactive protein and LMR retained their prognostic value in the multivariate model predicting OS. Comparing the WT group with controls, high LDH, high CRP, high NLR, and high PLR were associated with WT presence.ConclusionsPreoperative LDH, CRP, NLR, PLR, and LMR have significant prognostic value in patients with WT independently of age and stage. Combined low CRP and high LMR identified the group of patients with excellent OS. Patients with high LDH were characterized by the highest risk of relapse.

scholarly journals Markers of inflammation as risk predictors of lethal outcome in patients diagnosed with delirium

2016 ◽  
Vol 73 (9) ◽  
pp. 838-843 ◽  
Author(s):  
Ivana Stasevic-Karlicic ◽  
Milena Stasevic ◽  
Slobodan Jankovic ◽  
Slavica Djukic-Dejanovic ◽  
Srdjan Milovanovic
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
White Blood Cells ◽  
Adverse Outcomes ◽  
Control Group ◽  
Case Group ◽  
Lethal Outcome ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Risk Predictors

Background/Aim. Delirium is an acute or subacute, and most frequently reversible syndrome of higher cortical functions disturbances that is manifested as generalized disorder. If not prevented, it is associated with various adverse outcomes. The aim of this study was to determine the connection between the markers of inflammation and lethal outcome in patients diagnosed with delirium, hospitalized in the psychiatric intensive care unit. Methods. This retrospective study included 120 patients hospitalized in the psychiatric intensive care unit in whom examination of differences in inflammation markers was done. The examinees have been divided into two groups: the case group of 40 patients who died during the hospitalization, and the control group of 80 examinees who were discharged with the diagnosis Post delirium status. The following variables were taken into account: age, gender, clinical diagnosis of infection (pneumonia and urinary tract infection), laboratory parameters (total of white blood cells, granulocytes, monocytes, C-reactive protein ? CRP) and type of delirium (withdrawal or organic). Results. The average age of patients was 50.3 ? 13.1 years. The patients who survived delirium, were on the average 10.5 years younger than the deceased (p < 0.001). More than half (57.5%) of the deceased had pneumonia. There was a statistically significant correlation between pneumonia and lethal outcome in the patients with delirium (p < 0.001). The examinees with lethal outcome had significantly higher median CRP levels than the group of examinees who survived (75.6% ? 54.0 vs 30.3 ? 42.5 ng/L, p < 0.001). Conclusion. Aiming to better and more precise diagnostics of this complicated and still unclear neuropsychiatric syndrome it would be useful to consider introduction of more precise diagnostic algorithms in every unit of intensive care. That would significantly reduce the number of delirium diagnosis overlook, decrease complication of clinical features and would also reduce the unfavorable outcome rate, therefore the total cost of treatment.

scholarly journals Evaluation of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and C-Reactive Protein in Tension-Type Headache Patients

2021 ◽  
Author(s):  
Hasan Hüseyin Özdemir ◽  
Ahmet Dönder
Keyword(s):  
Systemic Inflammation ◽  
Tension Type Headache ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
C Reactive Protein ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Significant Difference ◽  
Type Headache

Abstract Objectives A tension headache is the most common type of headache, and its causes are multifactorial. A relationship has been shown between migraine headaches and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP). In this study, we investigated the NLR, PLR, and serum CRP levels in frequent episodic tension-type headache (FETTH) and chronic tension-type headache (CTTH) patients. Materials and Methods This retrospective study included 64 patients with FETTH, 80 patients with CTTH, and 60 healthy controls who were followed up in the neurology clinic. Hematological parameters were compared between the patient and control groups. Results In CTTH patients, platelets, NLR, PLR, and CRP values were statistically higher than in FETTH patients and patients in the control group. In FETTH patients, the PLR value was higher than in patients in the control group, but there was no statistically significant difference in NLR and CRP values between FETTH patients and patients in the control group. Also, there was no correlation between these values and age and gender. Conclusion Increase platelet count might have an effect on tension-type headache pathophysiology. Systemic inflammation parameters were shown to be significantly higher in CTTH patients. More comprehensive studies are needed to evaluate the effect of systemic inflammation on the chronicity of tension headaches.

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