scholarly journals The predictive value of serum myeloma protein in solitary plasmacytoma

2020 ◽  
Vol 38 (2) ◽  
pp. 129-137
Author(s):  
Won Ick Chang ◽  
Hyeon Kang Koh ◽  
Sung-Soo Yoon ◽  
Han-Soo Kim ◽  
Keun-Yong Eom ◽  
...  
Keyword(s):  
Predictive Value ◽  
Solitary Plasmacytoma ◽  
Myeloma Protein

Magnetic resonance imaging in the staging of solitary plasmacytoma of bone.

1993 ◽  
Vol 11 (7) ◽  
pp. 1311-1315 ◽  
Author(s):  
L A Moulopoulos ◽  
M A Dimopoulos ◽  
D Weber ◽  
L Fuller ◽  
H I Libshitz ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Primary Tumor ◽  
Radiation Treatment ◽  
Lumbosacral Spine ◽  
Solitary Plasmacytoma ◽  
Myeloma Protein ◽  
Signal Characteristics ◽  
Solitary Bone Plasmacytoma

PURPOSE To assess prospectively the role of magnetic resonance (MR) imaging in the staging of patients with a solitary bone plasmacytoma (SBP). PATIENTS AND METHODS Twelve consecutive patients with an apparent SBP underwent MR imaging of both the primary tumor and the thoracic and lumbosacral spine to seek additional foci of marrow involvement that might have been undetected by standard skeletal survey. All patients received megavoltage irradiation (total dose, 40 Gy) to the primary lesion. RESULTS MR imaging of the thoracic and lumbosacral spine showed additional foci of marrow replacement in four of 12 patients, with signal characteristics identical to those of the primary tumor. In all four patients, the abnormal protein persisted at greater than 50% of the pretreatment value following radiation treatment. In contrast, the myeloma protein disappeared or was reduced by greater than 50% in five of the six patients with secretory disease and without additional marrow abnormalities. One of four patients progressed to multiple myeloma 10 months after diagnosis with new lesions on conventional radiographs in the same areas as detected previously by MR imaging. CONCLUSION Four of 12 patients considered to have a SBP by standard criteria may have been understaged, because MR imaging showed additional marrow abnormalities consistent with myeloma. MR imaging of the spine may contribute to the initial staging of SBP, especially since some patients may be cured with radiotherapy.

The monoclonal gammopathies

1994 ◽  
Vol 40 (11) ◽  
pp. 2154-2161 ◽  
Author(s):  
R A Kyle
Keyword(s):  
Monoclonal Gammopathy ◽  
Extramedullary Plasmacytoma ◽  
Lymphocytic Leukemia ◽  
M Protein ◽  
Urine Specimen ◽  
Solitary Plasmacytoma ◽  
Related Disorder ◽  
Myeloma Protein ◽  
Cellulose Acetate Membranes ◽  
Polypeptide Chains

Abstract Each monoclonal protein (M-protein, or myeloma protein) consists of two heavy polypeptide chains of the same class and subclass and two light polypeptide chains of the same type. Electrophoresis on cellulose acetate membranes is satisfactory for screening, although agarose electrophoresis is more sensitive for detecting small M-proteins. Immunoelectrophoresis should be performed when myeloma, macroglobulinemia, amyloidosis, or a related disorder is suspected. Immunofixation is useful when results of immunoelectrophoresis are equivocal. The recognition of a Bence Jones protein depends on the demonstration of a monoclonal light chain by immunoelectrophoresis or immunofixation of an adequately concentrated urine specimen. The differential diagnosis of an M-protein includes monoclonal gammopathy of undetermined significance (benign monoclonal gammopathy), multiple myeloma, solitary plasmacytoma of bone or extramedullary plasmacytoma, macroglobulinemia, lymphoma, chronic lymphocytic leukemia, and primary systemic amyloidosis.

Persistence of myeloma protein for more than one year after radiotherapy is an adverse prognostic factor in solitary plasmacytoma of bone

Cancer ◽  
2002 ◽  
Vol 94 (5) ◽  
pp. 1532-1537 ◽  
Author(s):  
Richard B. Wilder ◽  
Chul S. Ha ◽  
James D. Cox ◽  
Donna Weber ◽  
Kay Delasalle ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Solitary Plasmacytoma ◽  
Myeloma Protein ◽  
Adverse Prognostic Factor ◽  
One Year

Curability of solitary bone plasmacytoma.

1992 ◽  
Vol 10 (4) ◽  
pp. 587-590 ◽  
Author(s):  
M A Dimopoulos ◽  
J Goldstein ◽  
L Fuller ◽  
K Delasalle ◽  
R Alexanian
Keyword(s):  
Disease Free Survival ◽  
Solitary Plasmacytoma ◽  
Survival Fraction ◽  
Myeloma Protein ◽  
Free Survival ◽  
Solitary Bone Plasmacytoma ◽  
Involved Field ◽  
Involved Field Radiotherapy ◽  
Extent Of Disease

PURPOSE The effects of involved-field radiotherapy were assessed in patients with a solitary plasmacytoma of bone (SBP). PATIENTS AND METHODS Forty-five consecutive patients with an SBP received megavoltage irradiation of at least 3,000 cGy. The median age was 53 years, 67% of patients showed a myeloma protein, and uninvolved immunoglobulins (Igs) were preserved in 93% of patients. RESULTS Permanent control of presenting disease was achieved in all but two patients, but 46% of patients developed multiple myeloma. When it occurred, progression of myeloma occurred within 3 years in two thirds of the patients, suggesting that the extent of disease was understaged at diagnosis. Myeloma protein disappeared in nine patients (30%) whose disease has not yet recurred. The median survival for all patients was 13 years and the myeloma-specific survival fraction at 10 years was 53%. CONCLUSION In patients with an SBP, the disappearance of myeloma protein with involved-field radiotherapy predicted long-term disease-free survival and possible cure. Nonsecretory disease and persistent myeloma protein after treatment were adverse prognostic factors for which adjuvant therapy with interferon alfa should be considered.

1423: The Impact of Gleason Score on the Predictive Value of PSA Doubling Time

2007 ◽  
Vol 177 (4S) ◽  
pp. 469-470 ◽  
Author(s):  
Stephen A. Boorjian ◽  
Sameer A. Siddiqui ◽  
Brant A. Inman ◽  
Jeffrey M. Slezak ◽  
R. Jeffrey Karnes ◽  
...  
Keyword(s):  
Gleason Score ◽  
Predictive Value ◽  
Doubling Time ◽  
Psa Doubling Time ◽  
The Impact

1497: Predictive Value of Proliferative Inflammatory Atrophy (PIA) for Prostate Cancer on Repeat Prostate Biopsy

2006 ◽  
Vol 175 (4S) ◽  
pp. 483-483
Author(s):  
Charlie Jung ◽  
Michael S. Cookson ◽  
Matthew J. Putzi ◽  
Sam S. Chang ◽  
Joseph A. Smith ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Biopsy ◽  
Predictive Value ◽  
Proliferative Inflammatory Atrophy

1712: Predictive Value of 3D Volume Rendered CT for Collecting System Entry Prior to Nephron Sparing Surgery

2005 ◽  
Vol 173 (4S) ◽  
pp. 464-464
Author(s):  
Ithaar H. Derweesh ◽  
Gaspar A. Motta-Ramirez ◽  
Mahesh Gael ◽  
Nancy Obuchowski ◽  
Hazem A. Moneim ◽  
...  
Keyword(s):  
Predictive Value ◽  
Nephron Sparing Surgery ◽  
Nephron Sparing ◽  
3D Volume ◽  
Collecting System

1412: Assessment of a Cleaved Product of E-Cadherin as a Serum Biomarker with Predictive Value for Prostate Cancer

2005 ◽  
Vol 173 (4S) ◽  
pp. 383-383
Author(s):  
Rainer Kuefer ◽  
Matthias D. Hofer ◽  
Christoph Zorn ◽  
Bjoern G. Volkmer ◽  
Juergen E. Gschwend ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Predictive Value ◽  
Serum Biomarker ◽  
E Cadherin
Sign in / Sign up

Export Citation Format

Share Document