scholarly journals Prognostic factors, failure patterns and survival analysis in patients with resectable oral squamous cell carcinoma of the tongue

2019 ◽  
Vol 37 (2) ◽  
pp. 73-81 ◽  
Author(s):  
Kanika Sharma ◽  
Parveen Ahlawat ◽  
Munish Gairola ◽  
Sarthak Tandon ◽  
Nishtha Sachdeva ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Survival Analysis ◽  
Prognostic Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Failure Patterns ◽  
Carcinoma Of The Tongue

Prognostic factors and survival analysis in a sample of oral squamous cell carcinoma patients

2008 ◽  
Vol 106 (5) ◽  
pp. 685-695 ◽  
Author(s):  
Lucinei Roberto Oliveira ◽  
Alfredo Ribeiro-Silva ◽  
João Paulo Oliveira Costa ◽  
Aguinaldo Luiz Simões ◽  
Miguel Angel Sala Di Matteo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Survival Analysis ◽  
Prognostic Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals Prognostic Significance of PD-L1 and mTOR Expression in Oral Squamous Cell Carcinoma

2020 ◽  
Author(s):  
Nattinee Charoen ◽  
Kitti Jantharapattana ◽  
Paramee Thongsuksai
Keyword(s):  
Squamous Cell Carcinoma ◽  
Regression Analysis ◽  
Prognostic Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cox Regression ◽  
Prognostic Significance ◽  
P Value ◽  
Cox Regression Analysis

Objective: Programmed cell death ligand 1 (PD-L1) and mammalian target of rapamycin (mTOR) are key players in host immune evasion and oncogenic activation, respectively. Evidence of the prognostic role in oral squamous cell carcinoma (OSCC) is conflicting. This study examined the associations of PD-L1 and mTOR expression with 5-year overall survival in OSCC patients. Material and Methods: The expressions of PD-L1 and mTOR proteins were immunohistochemically evaluated on tissue microarrays of 191 patients with OSCC who were treated by surgery at Songklanagarind Hospital, Thailand from 2008 to 2011. Cox regression analysis was used to determine independent prognostic factors. Results: PD-L1 expression was observed in 14.1% of cases while mTOR expression was present in 74.3% of cases. Females were more likely to have tumors with PD-L1 (p-value=0.007) and mTOR expressions (p-value=0.003) than males. In addition, lower clinical stage and well differentiated tumor are more likely to have mTOR expression (p-value= 0.038 and p-value<0.001, respectively). Cox regression analysis showed that age, tumor stage, nodal stage, combined surgical treatment with radiation or chemoradiation therapy, surgical margin status, PD-L1 expression and mTOR expression are independent prognostic factors. High PD-L1 expression (hazard ratio (HR) 3.14, 95% confidence interval (CI), 1.26–7.79) and high mTOR expression (HR 1.69, 95% CI, 1.00–2.84) are strong predictors of poor outcome. Conclusion: A proportion of OSCC expressed PD-L1 and mTOR proteins. Expression of PD-L1 and mTOR proteins are strong prognostic factors of OSCC.

Changing epidemiology of oral squamous cell carcinoma of the tongue: A global study

Head & Neck ◽  
2016 ◽  
Vol 39 (2) ◽  
pp. 297-304 ◽  
Author(s):  
Jia Hui Ng ◽  
N. Gopalakrishna Iyer ◽  
Min-Han Tan ◽  
Gustaf Edgren
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Global Study ◽  
Carcinoma Of The Tongue

scholarly journals pEGFR-Tyr 845 expression as prognostic factors in oral squamous cell carcinoma

2012 ◽  
Vol 13 (11) ◽  
pp. 967-977 ◽  
Author(s):  
Gabriella Aquino ◽  
Giuseppe Pannone ◽  
Angela Santoro ◽  
Giuseppina Liguori ◽  
Renato Franco ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell

Oral squamous cell carcinoma of the tongue: Prospective and objective speech evaluation of patients undergoing surgical therapy

Head & Neck ◽  
2015 ◽  
Vol 38 (7) ◽  
pp. 993-1001 ◽  
Author(s):  
Max Riemann ◽  
Christian Knipfer ◽  
Maximilian Rohde ◽  
Werner Adler ◽  
Maria Schuster ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Surgical Therapy ◽  
Squamous Cell ◽  
Speech Evaluation ◽  
Carcinoma Of The Tongue

Prognostic factors and outcomes for salvage surgery in patients with recurrent squamous cell carcinoma of the tongue

2013 ◽  
Vol 12 (1) ◽  
pp. e141-e148 ◽  
Author(s):  
Mitsuo Goto ◽  
Nobuhiro Hanai ◽  
Taijiro Ozawa ◽  
Hitoshi Hirakawa ◽  
Hidenori Suzuki ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Salvage Surgery ◽  
Recurrent Squamous Cell Carcinoma ◽  
Carcinoma Of The Tongue

Independent prognostic factors of 861 cases of oral squamous cell carcinoma in Korean adults

Oral Oncology ◽  
2006 ◽  
Vol 42 (2) ◽  
pp. 208-217 ◽  
Author(s):  
Keum-Kang Choi ◽  
Myung-Jin Kim ◽  
Pil-Young Yun ◽  
Jong-Ho Lee ◽  
Hyock-Soo Moon ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Korean Adults

scholarly journals The Outline of Prognosis and New Advances in Diagnosis of Oral Squamous Cell Carcinoma (OSCC): Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Esam Ahmad Omar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Imaging Techniques ◽  
Publication Date ◽  
Depth Of Invasion ◽  
Tumour Thickness

Objective. Oral squamous cell carcinoma (OSCC) has a remarkable incidence over the world and a fairly strenuous prognosis, encouraging further research on the prognostic factors and new techniques for diagnosis that might modify disease outcome. Data Sources. A web-based search for all types of articles published was initiated using Medline/Pub Med, with the key words such as oral cancer, prognostic factors of oral cancer, diagnostic method of oral cancer, and imaging techniques for diagnosis of oral cancer. The search was restricted to articles published in English, with no publication date restriction (last update April, 2013). Review Methods. In this paper, I approach the factors of prognosis of OSCC and the new advances in diagnostic technologies as well. I also reviewed available studies of the tissue fluorescence spectroscopy and other noninvasive diagnostic aids for OSCC. Results. The outcome is greatly influenced by the stage of the disease (especially TNM). Prognosis also depends or varies with tumour primary site, nodal involvement, tumour thickness, and the status of the surgical margins. Conclusion. Tumour diameter is not the most accurate when compared to tumour thickness or depth of invasion, which can be related directly to prognosis. There is a wide agreement on using ultrasound guided fine needle aspiration biopsies in the evaluation of lymph node metastasis.

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