scholarly journals Hepatitis G virus in Saudi blood donors and chronic hepatitis B and C patients

2014 ◽  
Vol 8 (01) ◽  
pp. 110-115 ◽  
Author(s):  
Abdulkarim Alhetheel ◽  
Malak Mohsen El-Hazmi
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Blood Donors ◽  
Study Groups ◽  
Exposure Rate ◽  
Hepatitis G Virus ◽  
Healthy Donors ◽  
Significant Difference ◽  
Chronic Hbv ◽  
Hepatitis G

Introduction: Screening blood donors for blood-borne pathogens is very critical for the recipient’s safety. Similar to hepatitis B and C infections, hepatitis G infection is transmitted through contaminated blood and causes acute and chronic hepatitis. Previous reports have shown that the prevalence of hepatitis G virus (HGV) RNA among healthy Saudi donors was 1%-2%. However, the exposure rate of this virus has never been studied. We hypothesized that the prevalence of HGV infection may have changed overtime due to socio-economic and environmental factors. Since hepatitis B and C infections are endemic in Saudi Arabia, we investigated the exposure rate of HGV infection in healthy donors and chronically infected hepatitis B and C patients. Methodology: A prospective study was done on healthy donors and patients with chronic HBV and HCV infections. Hepatitis B and C viral loads were measured by real-time polymerase chain reaction. HGV exposure rate was evaluated by detection of HGV antibodies. Results: Analysis of samples from healthy donors (n = 210), chronic HBV+ patients (n = 169), and chronic HCV+ patients (n = 105) showed that nine samples (4.3%), seven samples (4.1%), and four samples (3.8%) were positive for HGV antibodies, respectively. The non-significant difference in the exposure rates of HGV between the study groups may indicate that HGV infection occurs independent of HBV or HCV infections. Conclusions: We showed for the first time that the exposure rate of HGV infection among the Saudi population is 4.3%, and we recommend HGV screening for all blood donors.

scholarly journals Hepatitis G virus infection in chronic liver disease

Gut ◽  
1998 ◽  
Vol 42 (1) ◽  
pp. 107-111 ◽  
Author(s):  
M Guilera ◽  
J C Sáiz ◽  
F X López-Labrador ◽  
E Olmedo ◽  
S Ampurdanés ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
Blood Donors ◽  
Chronic Liver ◽  
Hepatitis G Virus ◽  
Cryptogenic Chronic Liver Disease

Background—The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood.Aims—To evaluate the prevalence and meaning of HGV infection in a large series of patients with chronic liver disease.Subjects—Two hundred volunteer blood donors, 179 patients with chronic hepatitis C, 111 with chronic hepatitis B, 104 with alcoholic liver disease, 136 with hepatocellular carcinoma, and 24 with cryptogenic chronic liver disease were studied.Methods—HGV RNA was investigated in serum samples by reverse transcription and polymerase chain reaction amplification of the 5′ non-coding region of HCV and hybridisation to a specific probe. The main features of HGV RNA seropositive and seronegative patients were compared.Results—The prevalence of HGV infection was 3% in blood donors, 7% in chronic hepatitis C, 8% in chronic hepatitis B, 2% in alcoholic liver disease, 4% in hepatocellular carcinoma, and 8% in cryptogenic chronic liver disease. HGV infected patients tended to be younger than non-infected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found.Conclusions—The prevalence of HGV infection in chronic liver disease seems to be relatively low in our area. Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection or to increased alcohol consumption, or in those with cryptogenic chronic liver disease.

scholarly journals Seroprevalence of HBsAg among blood donar’s in Sher-E-Bangla Medical College, Barisal

1970 ◽  
Vol 1 (1) ◽  
pp. 38-40
Author(s):  
G Mahmood ◽  
CR Debnath ◽  
B Biswas
Keyword(s):  
Hepatitis B ◽  
Blood Donors ◽  
Blood Donation ◽  
Medical Officer ◽  
College Hospital ◽  
Screening Programs ◽  
Medical College ◽  
Healthy Donors ◽  
Significant Difference ◽  
Age Range

Hepatitis B virus infection is a global health problem. About 350 to 400 million people are chronically infected with hepatitis B in the world. This is a retrospective study carried out in the department of transfusion medicine, Sher- E-Bangla Medical College Hospital, Barisal, during the period 1st January to 31st December 2007, among the blood donors who attended for blood donation. During this period 12,914 patients attended the department for transfusion. Among them 12,014 were male and 900 were female, age range was 18 to 60 years. Among them professional donors were 955, voluntary donors were 4494 and replacement donors were 7556 and HBsAg was positive in 0.42%, 0.87% and 1.11% respectively. Overall prevalence was 0.98%. The aim of this study was to determine the prevalence of HBsAg among blood donors at Sher-E-Bangla Medical College, Barisal. Blood samples were collected from 12914 healthy donors. All donors were pre-screened by a questionnaire provided by the institution and passed the physical examination conducted by the medical officer in charge. Blood donors data and results of HBsAg were analyzed using the blood bank's records. There was an overall prevalence of 0.98% of HBsAg(+) among all the tested blood donors. There was statistically significant difference between sexes. These results stress the importance of screening programs that must be implemented.   doi: 10.3329/blj.v1i1.2624 Bangladesh Liver Journal Vol.1(1) 2009 p.38-40 

Influence of GB virus-C/hepatitis G virus infection on the long term course of chronic hepatitis B

1998 ◽  
Vol 28 ◽  
pp. 188 ◽  
Author(s):  
G Fattovich ◽  
ML Ribero ◽  
S Favarato ◽  
F Azzario ◽  
F Donato ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Virus Infection ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis G Virus ◽  
Gb Virus C ◽  
Hepatitis G ◽  
Virus C

Phylogenetic Analysis of Hepatitis GB Virus Type C/Hepatitis G Virus in Spanish Patients with Chronic Hepatitis B or C Virus Infection

Intervirology ◽  
1998 ◽  
Vol 41 (6) ◽  
pp. 233-237 ◽  
Author(s):  
Juan Manuel López-Alcorocho ◽  
Maria José Amaro ◽  
Maria Cabrerizo ◽  
Marta Fogeda ◽  
Inmaculada Castillo ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Chronic Hepatitis ◽  
Virus Infection ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Virus Type ◽  
Hepatitis G Virus ◽  
Type C ◽  
Hepatitis G

Influence of GB virus-C/hepatitis G virus infection on the long-term course of chronic hepatitis B

2008 ◽  
Vol 18 (5) ◽  
pp. 360-365 ◽  
Author(s):  
Giovanna Fattovich ◽  
Maria Lisa Ribero ◽  
Susanna Favarato ◽  
Franco Azzario ◽  
Francesco Donato ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Virus Infection ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis G Virus ◽  
Gb Virus C ◽  
Hepatitis G ◽  
Virus C

scholarly journals Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibodies Levels in Chronic Viral Hepatitis (B&C)

2021 ◽  
pp. 49-57
Author(s):  
Ghada Mohamed Ramadan ◽  
Medhat Abd-Elmegied Ghazy ◽  
Maaly Mohamed Mabrouk ◽  
Mohamed Hassan El-Naggar
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Rheumatoid Factor ◽  
Significant Positive Correlation ◽  
Chronic Viral Hepatitis ◽  
Hbv Dna ◽  
Hcv Rna ◽  
Positive Correlation ◽  
Significant Difference ◽  
Chronic Hbv

Background: Extrahepatic manifestations is a relatively common feature in patients with chronic hepatitis C virus infection. Among the different clinical disorders associated with HCV infection, articular involvement is a frequent complication, and the clinical picture of HCV related arthropathy varies widely. In particular, monoarticular or oligoarticular involvement affects larger joints and is typically associated with mixed cryoglobulinemia, whereas symmetric polyarthritis associated with HCV infection frequently displays a rheumatoid arthritis like clinical picture which can be clinically indistinguishable from RA itself. This study aimed to evaluate level of Rheumatoid Factor and anti-CCP level in chronic viral hepatitis B&C. Patients and methods: Thirty patients with rheumatoid arthritis, thirty patients with                     chronic hepatitis C virus and thirty patients with chronic hepatitis B virus were selected to perform this study and they were compared to thirty normal subjects as a reference                                      group. Results: There was significant difference between the hemoglobin in the four groups. As regard Rheumatoid Factor there was significant difference between the studied groups. As regard Anti-CCP, there was significant difference between the studied groups. There was also significant difference between the four groups according to level of positivity. Finally, our study shows clinically significant positive correlation between RF as well as anti CCP titer and both HBV DNA and HCV RNA viral levels. Conclusions: Rheumatoid factor was found with considerable percentage in chronic HBV & HCV patients without musculoskeletal manifestations. Anti-CCP can be detected with low positivity in chronic HBV&HCV patients even without arthritic manifestations. There is a significant positive correlation between RF titre and HBV DNA& HCV RNA in chronic hepatitis patients. There is a significant positive correlation between anti-CCP and HBV DNA& HCV RNA in chronic hepatitis patients. Chronic HBV & HCV can be considered and investigated in patients with positive RF and/or anti CCP without arthritic manifestations.

Hepatitis G virus coinfection in chronic hepatitis B and C patients in Poland

Infection ◽  
1998 ◽  
Vol 26 (2) ◽  
pp. 113-115 ◽  
Author(s):  
M. Radkowski ◽  
W. Stańczak ◽  
B. Walewska-Zielecka ◽  
T. Łoch ◽  
J. Cianciara ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis G Virus ◽  
Hepatitis G
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