scholarly journals Role of immune response in Yersinia pestis infection

2011 ◽  
Vol 5 (09) ◽  
pp. 628-639 ◽  
Author(s):  
Amedeo Amedei ◽  
Elena Niccolai ◽  
Luigi Marino ◽  
Mario Milco D'Elios
Keyword(s):  
Immune Response ◽  
Yersinia Pestis ◽  
Far East ◽  
Adaptive Immune Response ◽  
Host Immune System ◽  
Adaptive Immune ◽  
Response Versus ◽  
North And South America ◽  
North And South

Yersinia pestis (Y. Pestis) is an infamous pathogen causing plague pandemics throughout history and is a selected agent of bioterrorism threatening public health. Y. pestis was first isolated by Alexandre Yersin in 1894 in Hong Kong and in the years to follow from all continents. Plague is enzootic in different rodents and their fleas in Africa, North and South America, and Asia such as Middle/Far East and ex-USSR countries. Comprehending the multifaceted interaction between Y. pestis and the host immune system will enable us design more effective vaccines. Innate immune response and both component (humoral and cellular) of adaptive immune response contribute to host defense against Y.pestis infection, but the bacterium possess different mechanisms to counteract the immune response. The aims of this review are to analyze the role of immune response versus Yersinia pestis infection and to highlight the various stratagems adopted by Y. pestis to escape the immunological defenses.

scholarly journals Pattern Recognition Proteins: First Line of Defense Against Coronaviruses

2021 ◽  
Vol 12 ◽  
Author(s):  
Carlos A. Labarrere ◽  
Ghassan S. Kassab
Keyword(s):  
Immune Response ◽  
Pattern Recognition ◽  
Global Economy ◽  
Rna Viruses ◽  
Severe Disease ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Recognition Protein ◽  
Pattern Recognition Protein

The rapid outbreak of COVID-19 caused by the novel coronavirus SARS-CoV-2 in Wuhan, China, has become a worldwide pandemic affecting almost 204 million people and causing more than 4.3 million deaths as of August 11 2021. This pandemic has placed a substantial burden on the global healthcare system and the global economy. Availability of novel prophylactic and therapeutic approaches are crucially needed to prevent development of severe disease leading to major complications both acutely and chronically. The success in fighting this virus results from three main achievements: (a) Direct killing of the SARS-CoV-2 virus; (b) Development of a specific vaccine, and (c) Enhancement of the host’s immune system. A fundamental necessity to win the battle against the virus involves a better understanding of the host’s innate and adaptive immune response to the virus. Although the role of the adaptive immune response is directly involved in the generation of a vaccine, the role of innate immunity on RNA viruses in general, and coronaviruses in particular, is mostly unknown. In this review, we will consider the structure of RNA viruses, mainly coronaviruses, and their capacity to affect the lungs and the cardiovascular system. We will also consider the effects of the pattern recognition protein (PRP) trident composed by (a) Surfactant proteins A and D, mannose-binding lectin (MBL) and complement component 1q (C1q), (b) C-reactive protein, and (c) Innate and adaptive IgM antibodies, upon clearance of viral particles and apoptotic cells in lungs and atherosclerotic lesions. We emphasize on the role of pattern recognition protein immune therapies as a combination treatment to prevent development of severe respiratory syndrome and to reduce pulmonary and cardiovascular complications in patients with SARS-CoV-2 and summarize the need of a combined therapeutic approach that takes into account all aspects of immunity against SARS-CoV-2 virus and COVID-19 disease to allow mankind to beat this pandemic killer.

Antigenic role of the adaptive immune response to d -ribose glycated LDL in diabetes, atherosclerosis and diabetes atherosclerotic patients

Life Sciences ◽  
2016 ◽  
Vol 151 ◽  
pp. 139-146 ◽  
Author(s):  
Firoz Akhter ◽  
M. Salman Khan ◽  
Abdulrahman A. Alatar ◽  
Mohammad Faisal ◽  
Saheem Ahmad
Keyword(s):  
Immune Response ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Glycated Ldl

scholarly journals Evidence for a role of adaptive immune response in the disease pathogenesis of the MPTP mouse model of Parkinson's disease

Glia ◽  
2015 ◽  
Vol 64 (3) ◽  
pp. 386-395 ◽  
Author(s):  
Heather L. Martin ◽  
Matteo Santoro ◽  
Sarah Mustafa ◽  
Gernot Riedel ◽  
John V. Forrester ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Immune Response ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Adaptive Immune Response ◽  
Disease Pathogenesis ◽  
Adaptive Immune

scholarly journals The Role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in Regulating the Innate and Adaptive Immune Response

2013 ◽  
Vol 69 (4) ◽  
pp. 383-394 ◽  
Author(s):  
Fernando F. Martinez ◽  
Laura Cervi ◽  
Carolina P. Knubel ◽  
Graciela M. Panzetta-Dutari ◽  
Claudia C. Motran
Keyword(s):  
Immune Response ◽  
Adaptive Immune Response ◽  
Adaptive Immune

Role of Aeromonas sp. involving in adaptive immune response of adult Lethenteron reissneri

Aquaculture ◽  
2021 ◽  
Vol 533 ◽  
pp. 736120
Author(s):  
Yingying Li ◽  
Nan Wang ◽  
Jingrui Zhang ◽  
Yihua Zhao ◽  
Yang Xu ◽  
...  
Keyword(s):  
Immune Response ◽  
Adaptive Immune Response ◽  
Adaptive Immune
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