scholarly journals A rare case of Colistin induced maculopapular rash

2020 ◽  
Vol 14 (08) ◽  
pp. 929-930
Author(s):  
Mandalapu Laasya ◽  
Ann V Kuruvilla
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Rare Case ◽  
Maculopapular Rash ◽  
Antibiotic Use ◽  
Hospitalized Patients ◽  
First Case ◽  
Cutaneous Reactions ◽  
Polymyxin E

Approximately 2–3% of hospitalized patients are known to experience an adverse drug reaction (ADR). Dermatologic ADRs account for 10–30% of ADRs, and are commonly reported to be associated with antibiotic use. The classes of antibiotics most commonly reported to cause cutaneous reactions are the penicillins, cephalosporins, and fluoroquinolones. Polymyxin E is known to cause such reactions, but rarely. Here, we report a case of a colistin- induced maculopapular rash in an 84-year-old male. To the best of our knowledge, this is the first case of colistin-induced maculopapular rash to be reported in India.

scholarly journals Dapsone induced photosensitivity in Indian women: a rare case

2017 ◽  
Vol 6 (4) ◽  
pp. 993
Author(s):  
Yashika Garg ◽  
Rajeshwari Gore ◽  
Sourabh Jain ◽  
Arun Kumar
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Drug Therapy ◽  
Rare Case ◽  
Adverse Reactions ◽  
Maculopapular Rash ◽  
Skin Lesions ◽  
Indian Women ◽  
Reduced Dose ◽  
Cutaneous Adverse Reactions

Dapsone, a potent antileprotic anti-inflammatory drug is used in treatment and prophylaxis of many dermatological and non dermatological conditions. Cutaneous adverse reactions to dapsone are uncommon ranging from mild maculopapular rash to fatal toxic epidermal necrolysis. We report here a case of 40-year-old, housewife treated for leprosy with paucibacillary multi drug therapy who presented with red itchy skin lesions over exposed areas of skin which worsened on exposure to sunlight. The patient was diagnosed as a case of dapsone-induced photosensitive dermatitis which was confirmed by improvement of symptoms on withdrawal of dapsone and recurrence of similar lesions on rechallenge with dapsone in reduced dose. Photosensitivity as adverse drug reaction to dapsone is rare and very few reports are available in the literature. 

scholarly journals Olanzapine-induced black hairy tongue: a rare case

2017 ◽  
Vol 6 (8) ◽  
pp. 2091
Author(s):  
Vishal P. Giri ◽  
Debranjan Datta ◽  
Parvathi Devi
Keyword(s):  
Bipolar Disorder ◽  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Case Report ◽  
Dopamine Receptors ◽  
Rare Case ◽  
Second Generation Antipsychotic ◽  
Black Hairy Tongue ◽  
Calming Effect ◽  
Prevention Of Relapse

Olanzapine is second generation antipsychotic drug. It alters affinities for serotonin and dopamine receptors and provides mild sedating and calming effect. It is indicated for the treatment of schizophrenia, acute mania and the prevention of relapse in bipolar disorder. We present a case report of a 65- year- old man with bipolar disorder I, who developed black hairy tongue following treatment with olanzapine and completely recovered after withdrawal of treatment. Awareness about this particular adverse drug reaction will ensure proper management and avoid unnecessary investigations.

scholarly journals PHP58 Direct Cost of Adverse Drug Reaction Treatment in Hospitalized Patients in Nakhon Pathom Hospital, Thailand

2012 ◽  
Vol 15 (7) ◽  
pp. A619
Author(s):  
J. Kornkaew ◽  
K. Auekusonsomboon ◽  
J. Junklub ◽  
J. Kongchat ◽  
P. Maitreemit ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Direct Cost ◽  
Hospitalized Patients

scholarly journals Challenges in Diagnosis and Management of Cutaneous Adverse Drug Reaction

2020 ◽  
Vol 18 (1) ◽  
pp. 1-2
Author(s):  
Manish Pradhan
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Significant Proportion ◽  
Multiple Drug ◽  
Drug Reactions ◽  
Drug Induced ◽  
Culprit Drug ◽  
Cutaneous Reactions ◽  
The Times ◽  
Cutaneous Adverse Drug Reaction

Adverse drug reactions commonly involve the skin and represent a significant proportion of all drug‐induced illnesses. Most of the times, adverse cutaneous reactions are not severe and only a few are fatal. Real incidence of cutaneous adverse drug reaction is not known. Due to rampant and multiple drug use, there is difficulty finding the culprit drug, so diagnosis of adverse drug reaction and management becomes difficult.

Case of relapsing sulfasalazine-induced hypersensitivity syndrome upon re-exposure

2020 ◽  
Vol 13 (9) ◽  
pp. e235803 ◽  
Author(s):  
Jason Winward ◽  
Laurel Lyckholm ◽  
Samuel M Brown ◽  
Mohamad Mokadem
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Crohn’S Disease ◽  
Hypersensitivity Syndrome ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Timely Initiation ◽  
Source Of Infection ◽  
First Case ◽  
Appropriate Treatment

Sulfasalazine-induced hypersensitivity syndrome (SIHS) is a serious systemic delayed adverse drug reaction that is associated with significant morbidity and mortality. Here, we report the first case, to our knowledge, of a patient with previously unidentified SIHS who developed a significantly more rapid and extreme recurrence on re-exposure to sulfasalazine. The patient is a 58-year-old woman with asymptomatic Crohn’s disease who, 10 days after initiating sulfasalazine, developed fevers, diffuse rash, pancytopenia, hypotension and hepatitis without a definitive source of infection. Sixteen days after her first hospitalisation, she was restarted on sulfasalazine and was readmitted within 10 hours with a similar but more serious presentation, requiring vasopressors. She did recover completely without any further recurrence to date, after definitively discontinuing sulfasalazine. This case demonstrates the importance of recognising SIHS early in patients to prevent re-exposure to sulfasalazine and to ensure timely initiation of appropriate treatment.

scholarly journals Cutaneous adverse drug reaction in Human Immunodeficiency virus patient associated with antiviral therapy: A retrospective study

2019 ◽  
Author(s):  
Vidyani Adiningtyas ◽  
Cita Rosita Sigit Prakoeswa ◽  
Erwin Astha Triyono
Keyword(s):  
Human Immunodeficiency Virus ◽  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Retrospective Study ◽  
Antiviral Therapy ◽  
General Hospital ◽  
Maculopapular Rash ◽  
Clinical Feature ◽  
Hiv Patients ◽  
Immunodeficiency Virus

Drug hypersensitivity reactions specifically cutaenous adverse drug reaction (CADR) occur at higher rate in human immunodeficiency virus (HIV)- positive patients than general population and cause significant morbidity, in early era of antiretroviral therapy (ART), the incidence of skin rashes can reach 50% in HIV patients taking HIV medications. The purpose of this study is to evaluate the pattern of CADR in HIV patients associated with ART. A retrospective study took data from medical record CADR in HIV patients associated with ART at HIV ward, Dr. Soetomo General Hospital Surabaya, since January 2013 until December 2015. During the period of three years, there were 20 CADR patients in at HIV ward, Dr. Soetomo General Hospital Surabaya. The most common patient was male, with the highest age group of 25-44 years old, and the most clinical feature found were maculopapular rash, and Steven Johnson Syndrome (SJS). The most common antiviral therapy were nevirapine. The number of CADR in HIV patient associated with ART cases increased. The most clinical feature were maculopapular rash followed by SJS, only few cases of toxic epidermal necrolysis.

scholarly journals Dermatitis medicamentosa- a rare case of adverse drug reaction due to sitagliptin

2017 ◽  
Vol 6 (5) ◽  
pp. 3716-3718
Author(s):  
Pradeep selvaraj ◽  
◽  
Preethi S ◽  
Selvaraj I ◽  
◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Rare Case

scholarly journals Hoigne Syndrome Caused by Intralesional Meglumine Antimoniate

2017 ◽  
Vol 5 (4) ◽  
pp. 483-485 ◽  
Author(s):  
Claudio Guarneri ◽  
Georgi Tchernev ◽  
Uwe Wollina ◽  
Torello Lotti
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Medical Literature ◽  
Meglumine Antimoniate ◽  
First Case ◽  
Intralesional Administration

Hoigne syndrome (HS) is the term coined to describe an acute, non-allergic, psychiatrically based reaction occurring with a wide list of medications, mainly antibiotics. Since its first description by Hoigne and Schoch in 1959, few cases have been reported in medical literature and, although antimicrobials are commonly used, very rarely in dermatology. The authors describe the first case occurred after intralesional administration of meglumine antimoniate and briefly discuss the pathogenetic hypotheses on this atypical adverse drug reaction.

scholarly journals Variability of surgical prophylaxis in penicillin-allergic children

2018 ◽  
Vol 39 (12) ◽  
pp. 1480-1483 ◽  
Author(s):  
David F. Butler ◽  
Brian R. Lee ◽  
Sarah Suppes ◽  
Tracy Sandritter ◽  
Jason G. Newland ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Antibiotic Prophylaxis ◽  
Broad Spectrum ◽  
Adverse Drug Events ◽  
Antibiotic Use ◽  
Broad Spectrum Antibiotic ◽  
Surgical Prophylaxis ◽  
Surgical Antibiotic Prophylaxis

AbstractWe retrospectively evaluated the effect of penicillin adverse drug reaction (ADR) labeling on surgical antibiotic prophylaxis. Cefazolin was administered in 86% of penicillin ADR-negative (−) and 28% penicillin ADR-positive (+) cases. Broad-spectrum antibiotic use was more common in ADR(+) cases and was more commonly associated with perioperative adverse drug events.

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