scholarly journals Does mass drug administration for community-based scabies control works? The experience in Ethiopia

2020 ◽  
Vol 14 (06.1) ◽  
pp. 78S-85S
Author(s):  
Wendemagegn Enbiale ◽  
Ashenafi Ayalew ◽  
Teklehaymanot Gebrehiwot ◽  
Yared Mulu ◽  
Muluken Azage ◽  
...  
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Cross Sectional Study ◽  
Political Commitment ◽  
Cure Rate ◽  
Community Based ◽  
Cross Sectional ◽  
The North ◽  
The Impact ◽  
North Gondar Zone

Introduction: After a scabies outbreak in Amhara Region, Ethiopia in 2015/2016, the Regional Health Bureau performed an extensive Mass Drug Administration (MDA). In May 2017, we collected data to assess the impact of the treatment on the scabies control. Methodology. We retrieved baseline data from the 2015/16 burden assessment: campaign organization and administration information. We did a community based cross-sectional study using a structured questionnaire on disease and treatment history plus the presence or absence of active scabies in three Zones. We selected households using stratified random sampling deployed 7581 questionnaires and performed key informant interviews. Results: 46.3% had a previous scabies diagnosis in the last 2 years of which 86.1% received treatment, and the cure rate was 90.6%. Fifteen months after intervention the scabies prevalence was 21.0 % (67.3% new cases and 32.7% recurrences). The highest burden of new cases (93.1%) was found in the North Gondar zone. The likelihood of treatment failure was higher for treatments offered in clinics (12.2%) as opposed to via the campaign (7.9%). Failure to follow the guidelines, shortage of medicine and lack of leadership prioritization were identified as reasons for resurgence of the disease. Conclusions: We demonstrated that community engagement is essential in the success of scabies MDA, alongside strong political commitment, and guideline adherence. Effectiveness and sustainability of the MDA was compromised by the failing of proper contact treatment, surveillance and case management.

Awareness and Coverage of Mass Drug Administration for Elimination of Lymphatic Filariasis: A Community Based Cross Sectional Study in Nepal

2014 ◽  
Vol 40 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Ram Kumar Adhikari ◽  
Jeevan Bahadur Sherchand ◽  
Shiva Raj Mishra ◽  
Kamal Ranabhat ◽  
Rajendra Raj Wagle
Keyword(s):  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional

scholarly journals Lymphatic Filariasis Profile in Dumka District of Jharkhand, India

2021 ◽  
Vol 8 (11) ◽  
pp. 364-369
Author(s):  
Vikas Oraon ◽  
Vidushi Topno
Keyword(s):  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Male And Female ◽  
Disease Spectrum

Lymphatic filariasis is a mosquito born disease infecting over 120 million people globally. This is a community based cross-sectional study done to assess the prevalence of disease in Dumka District of Jharkhand. Three years data (2018-2020) were used to know the disease spectrum in this region. The disease mostly presented itself in its chronic forms. Prevalence of the disease has decreased in three years duration. Lymphedema cases were predominant as it was seen in both male and female. The study showed Lymphedema cases as 52% in 2018, 88% in 2019 and 98% in 2020. Overall disease is significantly higher in males than in female. But, Elephantiasis is more frequent in females. Present study reveals that there is remarkable impact of ELF program showing significant reduction in number of cases in three years duration. But the study indicates that the disease still continues to be the major cause of disability and poverty. Keywords: Lymphatic filariasis, Mass drug administration, Elimination of Lymphatic Filariasis.

scholarly journals Mass Drug Administration Interruption by COVID-19 reportedly increases lymphatic filarial attacks, pains, and perceived increased lymphatic filarial infection transmission in rural Ghana

2021 ◽  
Author(s):  
Alexander Kwarteng ◽  
Yarhands Dissou Arthur ◽  
Samuel Opoku Asiedu ◽  
John Kanyiri Yamba ◽  
Emmanuel Kobla Amewu ◽  
...  
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Neglected Tropical Diseases ◽  
Cross Sectional Study ◽  
P Value ◽  
Chi Square ◽  
Statistical Tool ◽  
Cross Sectional ◽  
Rural Ghana ◽  
The Impact

Abstract BackgroundLike all other diseases, the advent of the COVID-19 pandemic has been implicated to impact the elimination schedule and control of neglected tropical diseases such as human lymphatic filarial (LF) infections in endemic countries. However, it is unclear the extent to which delays in mass drug administration has affected people living with chronic lymphatic filarial pathology in rural Ghana as a result of the COVID-19 pandemic, and thus remain to be investigated. MethodTo address this, a cross-sectional study where 133 LF participants from 8 LF-endemic communities in the Ahanta West District of Ghana were recruited to assess the impact of MDA interruptions as a result of COVID-19 among individuals presenting with the filarial pathology. Here, the chi-square test of independence was used as a statistical tool to assess the dependency: 1) between MDA interruption and filarial attacks 2) between MDA interruption and filarial-related pains 3) between MDA interruption and a perceived increase in LF transmission.ResultsStudy participants were asked whether the MDA interruption has affected them in any way. Here, 81% of the patients indicated yes, it had. In addition, we sought to investigate whether MDA interruption has resulted in increased filarial attacks and pains. At this, 68% of the study respondents reported an increase in filarial attacks. Similarly, 65% reported an increase in filarial-related pains. The study further reported that filarial attacks (B=14.997, df=1, p-value <0.001) and pains (a=11.773, df=1, p-value <0.001) are dependent on MDA interruption. Next, we further report that the perceived increase in LF transmission is dependent on MDA interruption (c=9.415, df=1, p-value=0.002). ConclusionIn this study, MDA interruption is reported to increase filarial attacks, filarial-related pains, and a perceived LF transmission increase in the study communities. This study's findings are important and urgent, suggesting that sustained MDA interruption in LF-endemic communities could further worsen LF patients' plight as filarial attacks, pains, and transmission could increase. Therefore, the need to immediately identify alternative modes of MDA distribution in LF-endemic areas where mass treatment has been halted in the wake of COVID-19 to prevent an unwarranted surge in LF attacks, pains, and transmission.

Non-compliance to Mass Drug Administration Associated with the Low Perception of the Community Members About their Susceptibility to Lymphatic Filariasis in Ankobra, Ghana

2020 ◽  
Vol 20 (2) ◽  
pp. 167-174
Author(s):  
Ilo Dicko ◽  
Yaya Ibrahim Coulibaly ◽  
Modibo Sangaré ◽  
Bismark Sarfo ◽  
Priscillia Awo Nortey
Keyword(s):  
Lymphatic Filariasis ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Health Workers ◽  
Compliance Rate ◽  
Cross Sectional Study ◽  
Cluster Sampling ◽  
Cross Sectional ◽  
Improve Compliance ◽  
Degree Of Association

Background: Lymphatic filariasis (LF) is a parasitic disease that has been targeted for elimination through the Mass Drug Administration (MDA.) Although the MDA started in the Ankobra community in Ghana in 2000, LF prevalence as reported in 2014 was relatively high (4.5%). Non-compliance to the MDA has been associated with the persistent LF prevalence in endemic regions. Objective: This study determined the factors associated with the non-compliance to the MDA among patients living in the Ankobra community, Ghana. Methods: A cross-sectional study using a one-stage cluster sampling method was used to collect data between June and July, 2017 in Ankobra. Questionnaires were used to collect data from health workers, the MDA drug distributors and study participants in Ankobra. Data analysis was performed using STATA 14. Logistic regression was used to measure the degree of association between the dependent (non-compliance) and independent variables. Non-compliance rate was defined as the percentage of individuals who self-reported that they did not actually swallow the drugs provided during the MDA. Results: The MDA coverage and non-compliance rates were 73.5% (147/200) and 33.33% (49/147) respectively. The main reason for non-compliance was fear of drug adverse events (75.51%, 37/49). Thought of “not being susceptible to LF” was significantly associated with the non-compliance (aOR= 2.83, [CI= 1.15, 6.98]). Conclusion: Health education about the susceptibility of residents getting LF disease in endemic community must be intensified to improve compliance to MDA medication ingestion and thus meet the Global Elimination of Lymphatic Filariasis by 2020.

scholarly journals Human population movement can impede the elimination of soil-transmitted helminth transmission in regions with heterogeneity in mass drug administration coverage and transmission potential between villages: a metapopulation analysis

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Carolin Vegvari ◽  
James E. Truscott ◽  
Klodeta Kura ◽  
Roy M. Anderson
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Human Population ◽  
Sub Saharan Africa ◽  
Population Movement ◽  
Mobility Patterns ◽  
Preventive Chemotherapy ◽  
Cross Sectional ◽  
The Impact ◽  
Human Population Movement

Abstract Background Soil-transmitted helminth (STH) infections affect predominantly socio-economically disadvantaged populations in sub-Saharan Africa, East Asia and the Americas. Previous mathematical modelling studies have evaluated optimal intervention strategies to break STH transmission in clusters of villages. These studies assumed that villages are closed independent units with no movement of people in or out of communities. Here we examine how human population movement, for example, of seasonal migrant labourers, affect the outcome of mass drug administration (MDA) programmes. Results We used a stochastic individual-based metapopulation model to analyse the impact of human population movement at varying rates on STH elimination efforts. Specifically, we looked at seasonal clumped movement events of infected individuals into a village. We showed that even if on average 75% of the entire resident population within a village are treated, an annual rate of 2–3% of the population arriving from an untreated source village can reduce the probability of STH elimination to less than 50% in high-prevalence settings. If a village is infection-free, an annual movement rate of 2–3% from an infected source village imposes a risk of re-introduction of STH of 75% or higher, unless the prevalence in the source village is less than 20%. Even a single arrival of 2–3% of the population can impose a risk of re-introducing STH of 50% or greater depending on the prevalence in the source village. The risk of re-introduction also depends on both the age group of moving individuals and STH species, since the pattern of cross-sectional age-prevalence and age-intensity profiles of infection in the human host are species-specific. Conclusions Planning for STH elimination programmes should account for human mobility patterns in defined regions. We recommend that individuals arriving from areas with ongoing STH transmission should receive preventive chemotherapy for STHs. This can most easily be implemented if migration is seasonal and overlaps with treatment rounds, e.g. seasonal migrant labour. Moreover, transmission hotspots in or near treatment clusters should be eliminated, for example, by implementing appropriate water, sanitation and hygiene (WASH) measures and targeting treatment to individuals living in hotspots.

scholarly journals Soil-Transmitted Helminth Reinfection and Associated Risk Factors among School-Age Children in Chencha District, Southern Ethiopia: A Cross-Sectional Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Zerihun Zerdo ◽  
Tsegaye Yohanes ◽  
Befikadu Tariku
Keyword(s):  
Risk Factors ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Predictor Variable ◽  
Cross Sectional Study ◽  
School Age Children ◽  
School Age ◽  
Sectional Study ◽  
Cross Sectional ◽  
Associated Risk Factors

Mass drug administration (MDA) to the most risky population including school-age children (SAC) is the central strategy to control soil-transmitted helminth (STH) infection. The present study was aimed at estimating the prevalence of STHs reinfection three months posttreatment and associated risk factors among SAC in Chencha district. A cross-sectional study design was employed from April 20 to May 5, 2015, to enroll 408 SAC. Structured questionnaire and Kato-Katz thick smear technique were used to interview parents or guardians and quantify the number of eggs per gram of stool. Pearson chi-square and logistic regression were used to assess the association between predictor variable and STH reinfection. The prevalence of STHs within three months of mass chemotherapy among SAC was 36.8% which is 93.4% of the prevalence (39.4%) before treatment. The estimated prevalence of reinfection (95%CI) forAscaris lumbricoides,Trichuris trichiura, and hookworms was 23.8% (21.1–28.2), 16.2% (12.7–20.1), and 1.0% (0.3–2.5), respectively. Children of merchant fathers were more likely to be reinfected by STHs in Chencha district. In conclusion, there is rapid reinfection after mass chemotherapy among SAC in Chencha district. Further studies should be carried out to generate cost efficient methods that can supplement mass drug administration to accelerate the control of STHs.

scholarly journals Bacteriological quality of household drinking water in North Gondar Zone, Ethiopia; a community-based cross-sectional study

2021 ◽  
Vol 11 (12) ◽  
Author(s):  
Atalay Getachew ◽  
Alebachew Tadie ◽  
Daniel Haile Chercos ◽  
Tadesse Guadu ◽  
Marta Alemayehu ◽  
...  
Keyword(s):  
Drinking Water ◽  
Occupational Status ◽  
Cross Sectional Study ◽  
Faecal Coliform ◽  
Sectional Study ◽  
Solid Waste Disposal ◽  
Community Based ◽  
Cross Sectional ◽  
Faecal Contamination ◽  
North Gondar Zone

AbstractEthiopia is one of the developing countries where only 52% of its population have access to safe drinking water. To determine the level of faecal contamination in drinking water, the E. coli has been found to be the most specific indicator. The purpose of this study was to determine household bacteriological drinking water quality and its associated factors in rural North Gondar Zone Ethiopia. A community-based cross-sectional study was conducted in rural parts of North Gondar Zone from April to June, 2016. Water samples from water storage at household level were taken using standardized water sampling techniques to determine the level of faecal contamination. Face-to-face interview using structured questionnaires and checklist were used to identify the associated factors. A total of 736 households participated in this study. The prevalence of positive faecal coliform in the households is found to be 72.6% (95%C.I; 69.4–75.8). In multivariate analysis; occupational status [AOR; 0.35, 95%; CI (0.16,0.77)], income [(AOR);0.45, 95%; CI (0.3, 0.68)], type of solid waste disposal habit [AOR; 0.16, 95%; CI (0.36, 0.66)], source of water [AOR; 0.42, 95%; CI (0.28, 0.65)], shortage of water [AOR; 2.8, 95%; CI (1.88, 4)] were variables identified as predictors for faecal coliform contamination of water in the household. There is high level of faecal contamination of household drinking water in North Gondar Zone. Occupational status, income, solid waste disposal habit, sources of drinking water, and shortage of water were predictor for presence of faecal coliform contamination in household drinking water.

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