scholarly journals Burden of fungal infections in Iran

2018 ◽  
Vol 12 (10) ◽  
pp. 910-918 ◽  
Author(s):  
Mohammad T Hedayati ◽  
Mojtaba Tagizadeh Armaki ◽  
Jamshid Yazdani Charati ◽  
Newsha Hedayati ◽  
Seyedmojtaba Seyedmousavi ◽  
...  
Keyword(s):  
Tinea Capitis ◽  
Fungal Infections ◽  
Hematologic Malignancy ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Epidemiological Data ◽  
Fungal Diseases ◽  
Relative Impact ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis ◽  
Populations At Risk

Introduction: The number of fungal infections occurring each year in Iran is not known. As the burden of fungal disease is a measure used to assess and compare the relative impact of different type of fungal diseases on populations, we have estimated the burden of fungal diseases in Iran. Methodology: We estimated the burden of human fungal diseases based on the specific populations at risk, existing epidemiological data in both local and international databases, and modelling previously described by the LIFE program (http://www.LIFE-worldwide.org). Results: Among the population of Iran (79,926,270 in 2016), 6,670,813 (8.3%) individuals are estimated to suffer from a fungal infection each year. A total of 2,791,568 women aged between 15 and 50 years are estimated to suffer from recurrent vulvovaginal candidiasis, annually. In addition, considering the 13.3% prevalence rate of tinea capitis in children, a total of 2,552,624 cases per year are estimated. The estimated burden of invasive aspergillosis in the 3 groups of patients with hematologic malignancy, lung cancer and chronic pulmonary obstructive disease was 6394 (8.0 per 100,000). The estimate for the burden of allergic disease related to fungi including allergic bronchopulmonary aspergillosis, severe asthma with fungal sensitization and allergic fungal rhinosinusitis was 272,095 (340 per 100,000). Based on the 28,663 cases of HIV infection reported, an estimated 900 and 113 cases with pneumocystosis and cryptococcal meningitis are annually anticipated, respectively. Conclusion: Our estimates indicate that the importance of fungal infections is high but overlooked in Iran, which warrants further actions by health care authorities.

scholarly journals Estimated burden of fungal infections in Kenya

2016 ◽  
Vol 10 (08) ◽  
pp. 777-784 ◽  
Author(s):  
John Abuga Guto ◽  
Christine C Bii ◽  
David W Denning
Keyword(s):  
At Risk ◽  
Fungal Infection ◽  
Tinea Capitis ◽  
Opportunistic Infections ◽  
Fungal Infections ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Epidemiological Studies ◽  
High Rate ◽  
Asthma Prevalence ◽  
Populations At Risk

Introduction: Kenya is a developing country with a high rate of tuberculosis (TB) and a moderate HIV infection burden. No estimate of the burden of fungal diseases in Kenya is published. Methodology: We used specific populations at risk and fungal infection frequencies from the literature to estimate national incidence or prevalence of serious fungal infections. Used sources were: 2010 WHO TB statistics, Kenya Acquired Immunodeficiency Syndrome (AIDS) Epidemic Update 2012, Kenya Facts and figures 2012, Kenya Demographic and Health Survey 2008-2009. Results: Of Kenya’s population of ~40 million, 43% are under 15 years old and approximately 594,660 Kenyan women get >4 episodes Candida vulvovaginitis annually (2,988/100,000). The HIV/AIDS population at risk of opportunistic infections (OI) is 480,000 and the OI estimates include 306,000 patients with oral thrush (768/100,000), 114,000 with oesophageal candidiasis (286/100,000), 11,900 with cryptococcal meningitis (29/100,000) and 17,000 patients with Pneumocystis pneumonia (42/100,000). Chronic pulmonary aspergillosis following TB has a prevalence of 10,848 cases (32/100,000). The adult asthma prevalence is 3.1% and assuming 2.5% have allergic bronchopulmonary aspergillosis then 17,696 (44/100,000) are affected.  Invasive aspergillosis, candidaemia and Candida peritonitis are probably uncommon. Tinea capitis infects 9.6% of children in Kenya, while fungal keratitis and otomycoses are difficult to estimate. Conclusion: At any one time, about 7% of the Kenyan population suffers from a significant fungal infection, with recurrent vaginitis and tinea capitis accounting for 82% of the infections. These estimates require further epidemiological studies for validation.

scholarly journals Estimated Burden of Fungal Infections in Oman

2020 ◽  
Vol 7 (1) ◽  
pp. 5
Author(s):  
Abdullah M. S. Al-Hatmi ◽  
Mohammed A. Al-Shuhoumi ◽  
David W. Denning
Keyword(s):  
Fungal Infection ◽  
Fungal Infections ◽  
Epidemiological Studies ◽  
Vaginal Candidiasis ◽  
Skin Infections ◽  
Opportunistic Pathogens ◽  
Fungal Rhinosinusitis ◽  
Populations At Risk ◽  
Different Populations ◽  
Underlying Pathology

For many years, fungi have emerged as significant and frequent opportunistic pathogens and nosocomial infections in many different populations at risk. Fungal infections include disease that varies from superficial to disseminated infections which are often fatal. No fungal disease is reportable in Oman. Many cases are admitted with underlying pathology, and fungal infection is often not documented. The burden of fungal infections in Oman is still unknown. Using disease frequencies from heterogeneous and robust data sources, we provide an estimation of the incidence and prevalence of Oman’s fungal diseases. An estimated 79,520 people in Oman are affected by a serious fungal infection each year, 1.7% of the population, not including fungal skin infections, chronic fungal rhinosinusitis or otitis externa. These figures are dominated by vaginal candidiasis, followed by allergic respiratory disease (fungal asthma). An estimated 244 patients develop invasive aspergillosis and at least 230 candidemia annually (5.4 and 5.0 per 100,000). Only culture and microscopy are currently available for diagnosis, so case detection is suboptimal. Uncertainty surrounds these figures that trigger the need for urgent local epidemiological studies with more sensitive diagnostics.

Benefit of Endoscopic Surgery in the Management of Acute Invasive Skull Base Fungal Rhinosinusitis

2020 ◽  
Vol 82 (S 03) ◽  
pp. e330-e334
Author(s):  
Megan R. D'Andrea ◽  
Corey M. Gill ◽  
Melissa Umphlett ◽  
Satish Govindaraj ◽  
Anthony Del Signore ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Mortality Rate ◽  
Skull Base ◽  
Fungal Infections ◽  
Hematologic Malignancy ◽  
Nasal Congestion ◽  
Postoperative Mortality ◽  
Surgical Interventions ◽  
Presenting Symptoms ◽  
Fungal Rhinosinusitis

Abstract Objective This article aims to characterize 14 patients who underwent purely endoscopic surgical debridement of acute invasive skull base fungal rhinosinusitis, and to evaluate postoperative outcomes and risk for recurrence. Design Retrospective cohort study. Setting Tertiary single-institution neurosurgery department. Participants We performed a retrospective analysis of all patients with skull base fungal infections treated with a purely endoscopic surgical approach at Mount Sinai Hospital from 1998 to 2018. Main Outcome Measures Clinical presentation, number of recurrences, and mortality rate. Results The most common underlying medical comorbidities were hematologic malignancy in 8 (57.1%) patients and poorly controlled diabetes mellitus in 7 (50%) patients. Presenting symptoms included headache (50%), eye pain (35.7%), facial pain (28.6%), visual changes (21.4%), and nasal congestion (14.3%). The fungal organisms identified on culture were Aspergillus (42.9%), Mucorales (28.6%), Fusarium (14.3%), Penicillium (7.1%), and unspecified (7.1%). Eight (57.1%) patients developed recurrence and required multiple surgical debridements. Patients who had only a hematologic malignancy were more likely to require multiple surgical debridements compared with those who did not have a hematologic malignancy or those who had both hematologic malignancy and underlying diabetes mellitus (p = 0.03). The mortality rate from surgery was 42.9%. Conclusion Surgical endoscopic intervention is an option for definitive management of acute invasive skull base fungal rhinosinusitis; however, postoperative mortality and risk of recurrence requiring additional surgical interventions remains high. Patients with hematologic malignancy may be more susceptible to recurrent infection requiring multiple surgical debridements. We recommend early aggressive multimodal treatment. Multiple debridements may be warranted in most cases; close clinical surveillance is needed during neurosurgical intervention.

scholarly journals The Burden of Fungal Infections in Ethiopia

2019 ◽  
Vol 5 (4) ◽  
pp. 109 ◽  
Author(s):  
Tufa ◽  
Denning
Keyword(s):  
Tinea Capitis ◽  
Fungal Infections ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Chronic Obstructive ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Obstructive Pulmonary Disease ◽  
Incidence Data ◽  
Patients At Risk ◽  
Chronic Pulmonary Aspergillosis ◽  
Candida Peritonitis

The burden of severe fungal infections (FIs) is not well addressed in Ethiopia. We have estimated the burden of FIs from multiple demographic sources and by searching articles from PubMed. Opportunistic FIs were estimated using modelling and 2017 national HIV data. The burdens of chronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary aspergillosis (ABPA) were estimated by using the prevalence of asthma, chronic obstructive pulmonary disease, and annual the incidence of tuberculosis. Of the 105,000,000 estimated Ethiopian population, 610,000 are thought to have HIV infection. Our estimation of HIV-related FIs were: 9900 cryptococcal meningitis (CM), 12,700 Pneumocystis jirovecii pneumonia (PCP), 76,300 oral and 56,000 oesophageal candidiasis cases. A remarkable 7,051,700 4–14-year-olds probably have tinea capitis and 1,469,000 women probably have recurrent Candida vaginitis. There were 15,200 estimated CPA cases (prevalence) and 11,500 invasive aspergillosis (IA) cases (incidence). Data are scant, but we estimated 5300 candidaemia and 800 Candida peritonitis cases. In conclusion, approximately 8% of Ethiopians suffer from FIs annually, mostly schoolchildren with tinea capitis. IA, CM and PCP are the major causes of fungal deaths. The absence of CD4 count is challenging the identification of HIV patients at risk of opportunistic FIs. There is a pressing need to improve FI diagnosis, probably including national surveillance.

A Concomitant Allergic Fungal Otomastoiditis with an Allergic Fungal Rhinosinusitis

2020 ◽  
pp. 1-3
Author(s):  
Vandersteen Clair ◽  
Vandersteen Clair ◽  
Johanna Pradelli ◽  
Grégoire D’andrea ◽  
Elisabeth Lanteri ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Medical Treatment ◽  
Middle Ear ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Purulent Discharge ◽  
Nasal Discharge ◽  
Middle Meatus ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis ◽  
The Face

Background: Allergic fungal otomastoiditis is a rare ear condition characterized by the presence of a specific middle ear mucus usually found in allergic bronchopulmonary aspergillosis. Methods: We report a case of concomitant allergic fungal otomastoiditis and rhinosinusitis in an immunocompetent 27-year-old man complaining of right otorrhea and nasal discharge for 6 months resistant to any medical treatment. Examination revealed a sticky mucus arising from a polypoid middle ear associated with a right middle meatus purulent discharge. Surgical treatment revealed no cholesteatoma but thick yellowish mucus and a fungal ball, as targeted by imaging, both of which containing Aspergillus species. Result: The patient received short postoperative systemic corticotherapy and showed no recurrence 6 months after. Discussion: Allergic fungal otomastoidis should be considered in the face of a sticky mucus arising from perforated chronic otitis, especially when associated with allergic fungal rhinosinusitis. Complete surgical debridement is essential.

scholarly journals Determining the burden of fungal infections in Zimbabwe

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lorraine T. Pfavayi ◽  
David W. Denning ◽  
Stephen Baker ◽  
Elopy N. Sibanda ◽  
Francisca Mutapi
Keyword(s):  
Tinea Capitis ◽  
Fungal Infections ◽  
Fungal Diseases ◽  
Chronic Obstructive ◽  
African Countries ◽  
Obstructive Pulmonary Disease ◽  
Pulmonary Tb ◽  
International Data ◽  
At Risk Populations ◽  
Hiv Aids

AbstractZimbabwe currently faces several healthcare challenges, most notably HIV and associated infections including tuberculosis (TB), malaria and recently outbreaks of cholera, typhoid fever and COVID-19. Fungal infections, which are also a major public health threat, receive considerably less attention. Consequently, there is dearth of data regarding the burden of fungal diseases in the country. We estimated the burden of fungal diseases in Zimbabwe based on published literature and ‘at-risk’ populations (HIV/AIDS patients, survivors of pulmonary TB, cancer, chronic obstructive pulmonary disease, asthma and patients receiving critical care) using previously described methods. Where there was no data for Zimbabwe, regional, or international data was used. Our study revealed that approximately 14.9% of Zimbabweans suffer from fungal infections annually, with 80% having tinea capitis. The annual incidence of cryptococcal meningitis and Pneumocystis jirovecii pneumonia in HIV/AIDS were estimated at 41/100,000 and 63/100,000, respectively. The estimated prevalence of recurrent vulvovaginal candidiasis (RVVC) was 2,739/100,000. The estimated burden of fungal diseases in Zimbabwe is high in comparison to other African countries, highlighting the urgent need for increased awareness and surveillance to improve diagnosis and management.

scholarly journals Burden of Serious Fungal Diseases in Romania

2018 ◽  
Author(s):  
Mihai Mareș ◽  
Valentina Ruxandra Moroti-Constantinescu ◽  
David W. Denning
Keyword(s):  
Fungal Infections ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Pneumocystis Pneumonia ◽  
Annual Incidence ◽  
Fungal Diseases ◽  
World Health ◽  
Annual Reports ◽  
Chronic Obstructive ◽  
Number Of Patients ◽  
Candida Peritonitis

Objective: To estimate for the first time the burden of serious fungal infections in Romania; Methods: Data derived from the World Health Organization (WHO), National Institute of Statistics, Romanian public health agencies and non-profit health organizations and published annual reports on local epidemiology were used in the present study. When no data was available, specific at-risk populations were used to calculate frequencies of serious fungal diseases, using previously published epidemiological parameters. All data refer to the year 2016; 3) Results: The estimated number of serious fungal infections in Romanian population was 435,930 in 2016. Recurrent vulvovaginal candidiasis accounts for up to 80% of total cases (more than 350,000 women annually). Concerning the HIV related infections, among 14349 infected persons, Pneumocystis pneumonia occurred in about 10% of late presenters (30 cases in 2016), while cryptococcal meningitis is rarely diagnosed (less than 20 cases). Annually, the total number of oesophageal candidiasis and oral thrush cases in HIV-positive patients may be as high as 1229 and 3066, respectively. In immunocompromised and cancer patient population, the annual incidence of candidaemia is 295, and at least 158 invasive aspergillosis cases and 4 mucormycosis cases occur yearly. With 4,966 critical care beds and approximately 200,000 abdominal surgeries performed, the estimated annual incidence of candidaemia and Candida peritonitis is 689 and 344, respectively. The annual incidence of pulmonary tuberculosis is still high in Romania (12,747 cases). Thus, the prevalence of post-TB chronic pulmonary aspergillosis is estimated to be 8.98/100,000 (1768 cases). The prevalence of chronic obstructive pulmonary disease (COPD) and asthma in adults is 6% and 6.5%, respectively. Therefore, allergic bronchopulmonary aspergillosis prevalence is estimated at 29,387 and severe asthma with fungal sensitisation at 38,731 cases annually. 4) Conclusions: Not being on the list of reportable diseases, the number of patients presenting with severe mycoses in Romania can only be roughly estimated. Based on local reports and prevalence estimation, we consider that at least 2.2% of Romanians suffer a serious form of fungal disease.

scholarly journals The burden of serious fungal infections in Sierra Leone: a national estimate

2021 ◽  
Vol 8 ◽  
pp. 204993612110279
Author(s):  
Sulaiman Lakoh ◽  
Emma Orefuwa ◽  
Matilda N. Kamara ◽  
Darlinda F. Jiba ◽  
Joseph B. Kamara ◽  
...  
Keyword(s):  
Sierra Leone ◽  
Fungal Infections ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Disease Diagnosis ◽  
Pneumocystis Pneumonia ◽  
Fungal Diseases ◽  
Resource Limited ◽  
Chronic Pulmonary Aspergillosis ◽  
Advanced Hiv Disease ◽  
And Control

Sierra Leone is a small, resource-limited country that has a low national prevalence of human immunodeficiency virus (HIV) and a very high burden of tuberculosis (TB). Fungal diseases are probably common, but poorly documented. In this article, we reviewed the existing literature on fungal epidemiology in Sierra Leone using national, regional, and international data, identified knowledge gaps, and propose solutions to address the challenges on the prevention and control of fungal diseases in Sierra Leone and similar countries. In advanced HIV disease, we estimate 300 cryptococcal meningitis, 640 Pneumocystis pneumonia, and over 4000 esophageal candidiasis cases annually. Chronic lung disease is common, with an estimated 6000 cases of chronic pulmonary aspergillosis, many mistaken for TB, 5000 adults with allergic bronchopulmonary aspergillosis complicating asthma, and probably over 6600 cases of severe asthma with fungal sensitization. Invasive aspergillosis is estimated at 478 cases. None of these diagnoses are made in Sierra Leone at present. Major burdens are recurrent vulvovaginal candidiasis (85,400) and tinea capitis in children (266,450). Improvement in fungal disease diagnosis in Sierra Leone will enable better estimates to be made and reduce morbidity and mortality.

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