Interim analysis of a 3-year follow-up study of NS5A and NS3 resistance-associated substitutions after treatment with grazoprevir-containing regimens in participants with chronic HCV infection

2018 ◽  
Vol 23 (7) ◽  
pp. 593-603 ◽  
Author(s):  
Frederick Lahser ◽  
Angela Galloway ◽  
Peggy Hwang ◽  
John Palcza ◽  
Joann Brunhofer ◽  
...  
Keyword(s):  
Interim Analysis ◽  
Hcv Infection ◽  
Follow Up Study ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

scholarly journals Long-term follow-up of clinical trial patients treated for chronic HCV infection with daclatasvir-based regimens

2017 ◽  
Vol 38 (5) ◽  
pp. 821-833 ◽  
Author(s):  
K. Rajender Reddy ◽  
Stanislas Pol ◽  
Paul J. Thuluvath ◽  
Hiromitsu Kumada ◽  
Joji Toyota ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hcv Infection ◽  
Long Term Follow Up ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

scholarly journals Incidence and Predictors of Advanced Liver Fibrosis by a Validated Serum Biomarker in Liver Transplant Recipients

2017 ◽  
Vol 2017 ◽  
pp. 1-8
Author(s):  
Mamatha Bhat ◽  
Kathleen C. Rollet-Kurhajec ◽  
Aparna Bhat ◽  
Amanda Farag ◽  
Marc Deschenes ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Liver Transplant ◽  
Hcv Infection ◽  
Serum Biomarker ◽  
Advanced Fibrosis ◽  
Advanced Liver Fibrosis ◽  
Chronic Hcv Infection ◽  
Chronic Hcv ◽  
Liver Transplant Recipients

Background and Aims. Serum fibrosis biomarkers have shown good accuracy in the liver transplant (LT) population. We employed a simple serum biomarker to elucidate incidence and predictors of advanced fibrosis after LT over a long follow-up period.Methods. We included 440 consecutive patients who underwent LT between 1991 and 2013. Advanced liver fibrosis was defined as FIB-4 > 3.25 beyond 12 months after LT.Results. Over 2030.5 person-years (PY) of follow-up, 189 (43%) developed FIB-4 > 3.25, accounting for an incidence of 9.3/100 PY (95% confidence interval [CI], 8.1–10.7). Advanced fibrosis was predicted by chronic HCV infection (adjusted hazard ratio (aHR) = 3.96, 95% CI 2.92–5.36,p< 0.001), hypoalbuminemia (aHR = 2.31, 95% CI 1.72–3.09;p< 0.001), and hyponatremia (aHR = 1.48, 95% CI 1.09–2.01;p= 0.01). LT recipients with more than 1 predictor had a higher incidence of advanced fibrosis, the highest being when all 3 predictors coexisted (log-rank:p< 0.001).Conclusions. Chronic HCV infection, hypoalbuminemia, and hyponatremia predict progression to advanced liver fibrosis following LT. Patients with these risk factors should be serially monitored using noninvasive fibrosis biomarkers and prioritized for interventions.

scholarly journals Effect of Baseline Resistance-Associated Substitutions on Thalassemia Patients with Chronic HCV Infection: A Two-Year Follow-Up

2021 ◽  
Vol 13 (1) ◽  
pp. 27-34
Author(s):  
Fahimeh Safarnezhad Tameshkel ◽  
Mohammad Hadi Karbalaie Niya ◽  
Mahmoodreza Khoonsari ◽  
Hossein Ajdarkosh ◽  
Amir Hossein Faraji ◽  
...  
Keyword(s):  
Hcv Infection ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

290 - Long-Term Follow-Up of Patients with Chronic HCV Infection and Compensated or Decompensated Cirrhosis Following Treatment with Sofosbuvir-Based Regimens

2018 ◽  
Vol 154 (6) ◽  
pp. S-1081
Author(s):  
Andrew J. Muir ◽  
Alessandra Mangia ◽  
Eric Lawitz ◽  
Edward Gane ◽  
Brian Conway ◽  
...  
Keyword(s):  
Hcv Infection ◽  
Decompensated Cirrhosis ◽  
Long Term Follow Up ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

scholarly journals Hepatitis C virus infection among teenagers in an endemic township in Taiwan: epidemiological and clinical follow-up studies

2001 ◽  
Vol 127 (3) ◽  
pp. 485-492 ◽  
Author(s):  
J. F. HUANG ◽  
S. N. LU ◽  
P. Y. CHUE ◽  
C. M. LEE ◽  
M. L. YU ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hcv Infection ◽  
Hcv Rna ◽  
Follow Up Studies ◽  
Screening Study ◽  
Long Term Follow Up ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

The aim of the study was to elucidate the epidemiological features of Hepatitis C virus (HCV) infection among teenagers in an endemic area by conducting a mass screening study. We also investigated the clinical outcome of the anti-HCV-positive subjects by conducting subsequent short-term and long-term follow-up studies. All 2837 students of two junior middle schools in Tzukuan, aged 13–16 years, were invited to be screened for anti-HCV, HBsAg, AST and ALT in October 1995. A total of 2726 (96%) students responded. Anti-HCV, HCV RNA and aminotransferase levels were evaluated among anti-HCV-positive students 1 month and 30 months later, respectively. A total of 38 (1·4%; M/F = 22/16) participants were anti-HCV-positive. The anti-HCV-positive students had higher rates of exposures to transfusion, anti-HCV-positive families and surgery. The prevalence (2·8%) of the 7 maritime villages was markedly higher than that (0·7%) of the other 8 villages (P < 0·001). Subsequent follow-up studies demonstrated that there might be 5 cases of acute or recent HCV infection, and 6 cases who had recovered from chronic HCV infection.

Spontaneous viral clearance of chronic HCV infection in Upper Egypt: A community-based study with a 10year follow-up

2010 ◽  
Vol 11 (4) ◽  
pp. 197-201 ◽  
Author(s):  
Madiha Mohamed El-Attar ◽  
Mohamed Abdel-Hamid Ahmed ◽  
Magda Shehata Hasan ◽  
Mohamed Ahmed Aly ◽  
Ahmed Medhat Nasr
Keyword(s):  
Viral Clearance ◽  
Hcv Infection ◽  
Community Based ◽  
Upper Egypt ◽  
Spontaneous Viral Clearance ◽  
Chronic Hcv Infection ◽  
Chronic Hcv
Sign in / Sign up

Export Citation Format

Share Document