scholarly journals Changes in abdominal fat following antiretroviral therapy initiation in HIV-infected individuals correlate with waist circumference and self-reported changes

2017 ◽  
Vol 22 (7) ◽  
pp. 577-586 ◽  
Author(s):  
Priya Bhagwat ◽  
Ighovwerha Ofotokun ◽  
Grace A McComsey ◽  
Todd T Brown ◽  
Carlee Moser ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Waist Circumference ◽  
Abdominal Fat ◽  
Therapy Initiation

scholarly journals Changes in Waist Circumference in HIV-Infected Individuals Initiating a Raltegravir or Protease Inhibitor Regimen: Effects of Sex and Race

2018 ◽  
Vol 5 (11) ◽  
Author(s):  
Priya Bhagwat ◽  
Ighovwerha Ofotokun ◽  
Grace A McComsey ◽  
Todd T Brown ◽  
Carlee Moser ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Repeated Measures ◽  
Health Management ◽  
Strong Predictor ◽  
Abdominal Fat ◽  
Baseline Viral Load ◽  
Predominantly Black ◽  
Therapy Initiation ◽  
Treatment Naïve ◽  
Inhibitor Regimen

Abstract Background This study investigates the association of clinical and demographic predictors with abdominal fat gain, measured using waist circumference (WC) and self-reported abdominal size. Methods We analyzed data from ACTG A5257, a clinical trial that randomized treatment-naïve HIV-infected participants to 1 of 3 antiretroviral regimens: raltegravir (RAL) or the protease inhibitors (PIs) atazanavir/ritonavir (ATV/r) or darunavir/ritonavir (DRV/r), each in combination with tenofovir disoproxil fumarate/emtricitabine. Associations of treatment and baseline/demographic characteristics with 96-week WC change were assessed using repeated-measures models. Ordinal logistic regression was used to examine the associations of predictors with week 96 self-reported abdominal changes. Results The study population (n = 1809) was 76.0% male and predominantly black non-Hispanic (41.9%) and white non-Hispanic (34.1%). Mean baseline WC was 90.6 cm, with an average 96-week increase of 3.4 cm. WC increases were higher in the RAL arm compared with DRV/r (P = .0130). Females experienced greater increases in WC on RAL vs ATV/r than males (P = .0065). Similarly, a larger difference in WC change was found for RAL vs DRV/r for black vs nonblack individuals (P = .0043). A separate multivariable model found that in addition to the treatment regimen, higher baseline viral load and lower CD4+ were also associated with WC increases. Conclusions With antiretroviral therapy initiation, higher WC increases in the RAL arm compared with PIs were more pronounced in female and black participants, and a more advanced baseline HIV disease state was a strong predictor of larger abdominal increases. Understanding factors predisposing individuals to abdominal fat gain could inform health management after therapy initiation.

scholarly journals Waist Circumference Adjusted for Body Mass Index and Intra-Abdominal Fat Mass

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e32213 ◽  
Author(s):  
Tina Landsvig Berentzen ◽  
Lars Ängquist ◽  
Anna Kotronen ◽  
Ronald Borra ◽  
Hannele Yki-Järvinen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Fat Mass ◽  
Abdominal Fat

Patient Loss to Follow-Up Before Antiretroviral Therapy Initiation in Rural Mozambique

2014 ◽  
Vol 19 (4) ◽  
pp. 666-678 ◽  
Author(s):  
Monica da Silva ◽  
Meridith Blevins ◽  
C. William Wester ◽  
José Manjolo ◽  
Eurico José ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Loss To Follow Up ◽  
Therapy Initiation

scholarly journals Impact of highly active antiretroviral therapy initiation on CD4+ T-cell repopulation in duodenal and rectal mucosa

AIDS ◽  
2013 ◽  
Vol 27 (6) ◽  
pp. 867-877 ◽  
Author(s):  
Timothy L. Hayes ◽  
David M. Asmuth ◽  
J. William Critchfield ◽  
Thomas H. Knight ◽  
Bridget E. McLaughlin ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Rectal Mucosa ◽  
Cd4 T Cell ◽  
Highly Active ◽  
Therapy Initiation ◽  
Cell Repopulation

Longitudinal increases in waist circumference are associated with HIV-serostatus, independent of antiretroviral therapy

AIDS ◽  
2007 ◽  
Vol 21 (13) ◽  
pp. 1731-1738 ◽  
Author(s):  
Todd T Brown ◽  
Haitao Chu ◽  
Zhaojie Wang ◽  
Frank J Palella ◽  
Lawrence Kingsley ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Waist Circumference ◽  
Hiv Serostatus
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