Decline in serum 25-OH vitamin D levels in HIV/hepatitis B virus (HBV) co-infected patients after long term antiretroviral therapy

2013 ◽  
Vol 19 (1) ◽  
pp. 41-49 ◽  
Author(s):  
Anchalee Avihingsanon ◽  
◽  
Tanakorn Apornpong ◽  
Reshmie A Ramautarsing ◽  
Sasiwimol Ubolyam ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hepatitis B Virus ◽  
Antiretroviral Therapy ◽  
Hepatitis B ◽  
Vitamin D Levels ◽  
B Virus ◽  
25 Oh Vitamin D

scholarly journals Long-Term Hepatitis B Virus (HBV) Response to Lamivudine-Containing Highly Active Antiretroviral Therapy in HIV-HBV Co-Infected Patients in Thailand

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e42184 ◽  
Author(s):  
Woottichai Khamduang ◽  
Catherine Gaudy-Graffin ◽  
Nicole Ngo-Giang-Huong ◽  
Gonzague Jourdain ◽  
Alain Moreau ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Antiretroviral Therapy ◽  
Hepatitis B ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active ◽  
B Virus

scholarly journals The 25(OH)Vitamin D Status Affected the Effectiveness of Oligo Fucoidan in Patients with Chronic Hepatitis B Virus Infection with Immune Tolerance Phase

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 321 ◽  
Author(s):  
Wang-Sheng Ko ◽  
Fang-Ping Shen ◽  
Chia-Ju Shih ◽  
Ya-Ling Chiou
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Tolerance ◽  
Hbv Infection ◽  
Vitamin D Status ◽  
Chronic Hepatitis B Virus ◽  
B Virus ◽  
25 Oh Vitamin D

Chronic hepatitis B virus (HBV) infection is a serious public health issue. Vitamin D is involved in various pathophysiological mechanisms as an immune modulator and the deficiency rate of vitamin D is prevalent in chronic liver disease. Fucoidan exerts anti-inflammatory, anticoagulant, antitumor, antimetastatic, and antiangiogenetic effects; however, its effect on the immune responses of HBV patients is unclear. This study investigated how 25(OH)Vitamin D status affected the effectiveness of oligo fucoidan in patients with HBV infection in the immune tolerance phase. Fifty-one patients received oligo fucoidan 4400 mg/day for 48 weeks. Flow cytometry was used to detect T lymphocyte markers (CD3+CD4+, CD3+CD8+, CD4+CD45RO+, CD8+CD45RO+). The levels of white blood cell (WBC), platelets (PLT), and albumin were decreased after 48 weeks of supplementation (p < 0.05). Percentages of CD3+CD8+ and CD8+CD45RO+ cells were decreased after 12 weeks of supplementation (p < 0.05). In patients with adequate vitamin D, HBV-DNA concentrations decreased and the proportion of CD4+CD45RO+ and CD8+CD45RO+ cells increased upon oligo fucoidan supplementation. The HBeAg status of one vitamin D-adequate patient changed from positive to negative at the 12th week of supplementation. The oligo fucoidan may regulate immune effects in patients with HBV infection, and the 25(OH)Vitamin D status might have affected the effectiveness of oligo fucoidan.

SAT-188-Expansion and genetic modification of primary hepatocytes to study long-term hepatitis B virus infection

2019 ◽  
Vol 70 (1) ◽  
pp. e712
Author(s):  
Eleftherios Michailidis ◽  
Paul Park ◽  
Mohammad Kabbani ◽  
Liliana Mancio Silva ◽  
Yingpu Yu ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Genetic Modification ◽  
Hepatitis B Virus Infection ◽  
Primary Hepatocytes ◽  
B Virus
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