Baseline hepatitis B surface antigen (HBsAg) as predictor of sustained HBsAg loss in chronic hepatitis B patients treated with peginterferon alfa-2a and adefovir

2013 ◽  
Vol 18 (7) ◽  
pp. 895-904 ◽  
Author(s):  
R Bart Takkenberg ◽  
Louis Jansen ◽  
Annikki de Niet ◽  
Hans L Zaaijer ◽  
Christine J Weegink ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Hbsag Loss ◽  
Peginterferon Alfa

scholarly journals Usefulness of a Hepatitis B Surface Antigen-Based Model for the Prediction of Functional Cure in Patients with Chronic Hepatitis B Virus Infection Treated with Nucleos(t)ide Analogues: A Real-World Study

2021 ◽  
Vol 10 (15) ◽  
pp. 3308
Author(s):  
Gian Paolo Caviglia ◽  
Yulia Troshina ◽  
Enrico Garro ◽  
Marcantonio Gesualdo ◽  
Serena Aneli ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Functional Cure ◽  
Hbsag Loss ◽  
Chronic Hepatitis B Virus ◽  
Long Term Treatment ◽  
Hbsag Seroclearance

In patients with chronic hepatitis B (CHB) under long-term treatment with nucleso(t)ide analogues (NAs), the loss of hepatitis B surface antigen (HBsAg) is a rare event. A growing body of evidence supports the use of quantitative HBsAg for the prediction of functional cure, although these results are mainly derived from studies performed on Asian patients with hepatitis B e antigen (HBeAg)-positive CHB. Here, we investigated the clinical role of quantitative HBsAg in a real-life cohort of CHB patients under treatment with NAs in a tertiary care center from North-West Italy. A total of 101 CHB patients (HBeAg-negative, n = 86) undergoing NAs treatment were retrospectively enrolled. HBsAg was measured at baseline (T0), 6 months (T1), 12 months (T2) and at the last follow-up (FU). Median FU was 5.5 (3.2–8.3) years; at the end of FU, 11 patients lost the HBsAg (annual incidence rate = 1.8%). Baseline HBsAg levels were significantly different between patients with no HBsAg loss and those achieving a functional cure (3.46, 2.91–3.97 vs. 1.11, 0.45–1.98 Log IU/mL, p < 0.001). Similarly, the HBsAg decline (Δ) from T0 to T2 was significantly different between the two groups of patients (0.05, −0.04–0.13, vs. 0.38, 0.11–0.80 Log IU/mL, p = 0.002). By stratified cross-validation analysis, the combination of baseline HBsAg and ΔHBsAg T0–T2 showed an excellent accuracy for the prediction of HBsAg loss (C statistic = 0.966). These results corroborate the usefulness of quantitative HBsAg in Caucasian CHB patients treated with antivirals for the prediction of HBsAg seroclearance.

scholarly journals A case of chronic hepatitis B which achieved hepatitis B surface antigen seroclearance during combination therapy with peginterferon alfa-2b and entecavir

Kanzo ◽  
2012 ◽  
Vol 53 (1) ◽  
pp. 42-47
Author(s):  
Tadashi Inuzuka ◽  
Yukio Osaki ◽  
Fumihiro Matsuda ◽  
Azusa Sakamoto ◽  
Keiichi Hatamaru ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Combination Therapy ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Peginterferon Alfa

Serum Levels of Hepatitis B Surface Antigen Predict Severity of Fibrosis in Patients With E Antigen-Positive Chronic Hepatitis B

2015 ◽  
Vol 13 (8) ◽  
pp. 1532-1539.e1 ◽  
Author(s):  
Patrick Marcellin ◽  
Michelle Martinot-Peignoux ◽  
Tarik Asselah ◽  
Richard Batrla ◽  
Diethelm Messinger ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Serum Levels ◽  
Positive Chronic Hepatitis
Sign in / Sign up

Export Citation Format

Share Document