Etravirine: clinical review of a treatment option for HIV type-1-infected patients with non-nucleoside reverse transcriptase inhibitor resistance

2010 ◽  
Vol 15 (6) ◽  
pp. 803-816 ◽  
Author(s):  
William J Towner ◽  
Isabel Cassetti ◽  
Pere Domingo ◽  
Steven Nijs ◽  
Thomas N Kakuda ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Clinical Review ◽  
Treatment Option ◽  
Nucleoside Reverse Transcriptase Inhibitor ◽  
Transcriptase Inhibitor ◽  
Hiv Type 1 ◽  
Inhibitor Resistance ◽  
Reverse Transcriptase Inhibitor

Efavirenz Is a Potent Nonnucleoside Reverse Transcriptase Inhibitor of HIV Type 1 Replication in Microgliain Vitro

2000 ◽  
Vol 16 (15) ◽  
pp. 1527-1537 ◽  
Author(s):  
Andrew V. Albright ◽  
Susan Erickson-Viitanen ◽  
Michael O'Connor ◽  
Ian Frank ◽  
Marlene M. Rayner ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Transcriptase Inhibitor ◽  
Nonnucleoside Reverse Transcriptase Inhibitor ◽  
Hiv Type 1 ◽  
Reverse Transcriptase Inhibitor

scholarly journals Differentiated Care Pathways for Antiretroviral Therapy Monitoring in Malawi: Expanding Viral Load Testing in Setting of Highly Prevalent Resistance

2017 ◽  
Vol 4 (3) ◽  
Author(s):  
Sarah E Rutstein ◽  
Kara Compliment ◽  
Julie A E Nelson ◽  
Deborah Kamwendo ◽  
Ronald Mataya ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Reverse Transcriptase ◽  
Nucleoside Reverse Transcriptase Inhibitor ◽  
Therapy Monitoring ◽  
Transcriptase Inhibitor ◽  
Load Testing ◽  
First Line ◽  
Inhibitor Resistance ◽  
Reverse Transcriptase Inhibitor ◽  
Differentiated Care

Abstract We quantified resistance to first-line antiretroviral therapy among previously unmonitored patients in Malawi with viremia (≥1000 copies/mL). Ninety-five percent (n = 57/61) harbored nucleoside/tide reverse transcriptase inhibitor/non-nucleoside reverse transcriptase inhibitor resistance; resistance was more common comparing >2 (97%) versus ≤2 years (87%) on therapy. Immediate switch for persons retained in care may improve monitoring efficiency and maximize clinical outcomes.

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