Treatment of acute HCV infection in HIV-positive patients: experience from a multicentre European cohort

2010 ◽  
Vol 15 (2) ◽  
pp. 267-273 ◽  
Author(s):  
Martin Vogel ◽  
Stéphanie Dominguez ◽  
Sanjay Bhagani ◽  
Alex Azwa ◽  
Emma Page ◽  
...  
Keyword(s):  
Hcv Infection ◽  
Hiv Positive ◽  
Acute Hcv ◽  
Patients Experience ◽  
Acute Hcv Infection

Molecular epidemiology of acute HCV infection in HIV–positive patients from Hong Kong, Taipei, Tokyo

2019 ◽  
Vol 39 (6) ◽  
pp. 1044-1051 ◽  
Author(s):  
Hsin‐Yun Sun ◽  
Haruka Uemura ◽  
Ngai‐Sze Wong ◽  
Denise P‐C Chan ◽  
Bonnie C‐K Wong ◽  
...  
Keyword(s):  
Hong Kong ◽  
Molecular Epidemiology ◽  
Hcv Infection ◽  
Hiv Positive ◽  
Acute Hcv ◽  
Acute Hcv Infection

561 Pidemiology of acute HCV infection in a London cohort of HIV positive homosexual males

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 431-431 ◽  
Author(s):  
M DANTA ◽  
D BROWN ◽  
M JACOBS ◽  
G DUSHEIKO ◽  
S BHAGANI
Keyword(s):  
Hcv Infection ◽  
Hiv Positive ◽  
Acute Hcv ◽  
Acute Hcv Infection

scholarly journals Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

2000 ◽  
Vol 191 (9) ◽  
pp. 1499-1512 ◽  
Author(s):  
Franziska Lechner ◽  
David K.H. Wong ◽  
P. Rod Dunbar ◽  
Roger Chapman ◽  
Raymond T. Chung ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Acute Infection ◽  
Hcv Infection ◽  
Ctl Response ◽  
Acute Hcv ◽  
Ifn Γ ◽  
Acute Hcv Infection

Although hepatitis C virus (HCV) infection is very common, identification of patients during acute infection is rare. Consequently, little is known about the immune response during this critical stage of the disease. We analyzed the T lymphocyte response during and after acute resolving HCV infection in three persons, using interferon (IFN)-γ enzyme-linked immunospot (ELISPOT) and human histocompatibility leukocyte antigen (HLA) peptide tetramer assays. Acute infection was associated with a broadly directed T helper and cytotoxic T lymphocyte (CTL) response, which persisted after resolution of clinical hepatitis and clearance of viremia. At the earliest time point studied, highly activated CTL populations were observed that temporarily failed to secrete IFN-γ, a “stunned” phenotype, from which they recovered as viremia declined. In long-term HCV-seropositive persons, CTL responses were more common in persons who had cleared viremia compared with those with persistent viremia, although the frequencies of HCV-specific CTLs were lower than those found in persons during and after resolution of acute HCV infection. These studies demonstrate a strong and persistent CTL response in resolving acute HCV infection, and provide rationale to explore immune augmentation as a therapeutic intervention in chronic HCV infection.

799 KINETICS OF HEPATIC AND CIRCULATING MICRORNA-122 DURING EXPERIMENTAL ACUTE HCV INFECTION

2011 ◽  
Vol 54 ◽  
pp. S320-S321
Author(s):  
K. Krawczynski ◽  
Y. Choi ◽  
M. Odenthal ◽  
M. Ruhrlander ◽  
M. Muller ◽  
...  
Keyword(s):  
Hcv Infection ◽  
Circulating Microrna ◽  
Acute Hcv ◽  
Kinetics Of ◽  
Acute Hcv Infection

scholarly journals PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion

2006 ◽  
Vol 80 (22) ◽  
pp. 11398-11403 ◽  
Author(s):  
Simona Urbani ◽  
Barbara Amadei ◽  
Daniela Tola ◽  
Marco Massari ◽  
Simona Schivazappa ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cell Function ◽  
Hcv Infection ◽  
Acute Hepatitis C ◽  
Inhibitory Receptor ◽  
Cd8 Cells ◽  
Acute Hcv ◽  
Cd8 Cell ◽  
Acute Hcv Infection

ABSTRACT Hepatitis C virus (HCV)-specific CD8 cell exhaustion may represent a mechanism of HCV persistence. The inhibitory receptor PD-1 has been reported to be up-regulated in exhausted CD8 cells. Therefore, we studied PD-1 expression longitudinally during acute HCV infection. Most HCV-specific CD8 cells expressed PD-1 at the time of acute illness, irrespective of the final outcome. PD-1 expression declined with the acquisition of a memory phenotype and recovery of an efficient CD8 cell function in resolving HCV infections, whereas high levels were maintained when HCV persisted and HCV-specific CD8 cells remained dysfunctional. Blocking PD-1/PDL-1 interaction with an anti-PDL-1 antibody improved the capacity of expansion of virus-specific CD8 cells.

894 FEMALE SEX AND VARIATIONS IN IL28B ARE INDEPENDENTLY ASSOCIATED WITH SPONTANEOUS CLEARANCE OF ACUTE HCV INFECTION

2012 ◽  
Vol 56 ◽  
pp. S348
Author(s):  
J. Grebely ◽  
G.J. Dore ◽  
M. Schim van der Loeff ◽  
T. Rice ◽  
A.L. Cox ◽  
...  
Keyword(s):  
Hcv Infection ◽  
Spontaneous Clearance ◽  
Female Sex ◽  
Acute Hcv ◽  
Acute Hcv Infection

scholarly journals High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

2011 ◽  
Vol 85 (9) ◽  
pp. 4633-4633
Author(s):  
V. Kasprowicz ◽  
J. S. zur Wiesch ◽  
T. Kuntzen ◽  
B. E. Nolan ◽  
S. Longworth ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Clinical Outcome ◽  
Cd4 T Cells ◽  
Hcv Infection ◽  
Acute Hcv ◽  
High Level ◽  
Acute Hcv Infection

High efficacy of IFN-free DAA therapy for acute HCV infection in HIV patients

2018 ◽  
Vol 68 ◽  
pp. S273
Author(s):  
D. Chromy ◽  
M. Mandorfer ◽  
T. Bucsics ◽  
P. Schwabl ◽  
B. Scheiner ◽  
...  
Keyword(s):  
Hcv Infection ◽  
High Efficacy ◽  
Hiv Patients ◽  
Acute Hcv ◽  
Acute Hcv Infection
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