scholarly journals Epitope Mapping of Dengue-Virus-Enhancing Monoclonal-Antibody Using Phage Display Peptide Library

2008 ◽  
Vol 4 (1) ◽  
pp. 76-84 ◽  
Author(s):  
Chung-I Rai ◽  
Huan-Yao Lei ◽  
Yee-Shin Lin ◽  
Hsiao-Sheng Liu ◽  
Shun-Hua Chen ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Dengue Virus ◽  
Phage Display ◽  
Epitope Mapping ◽  
Peptide Library ◽  
Phage Display Peptide Library

Epitope mapping of bovine alpha-lactalbumin using a random phage display peptide library

1997 ◽  
Vol 25 (2) ◽  
pp. 160S-160S
Author(s):  
ALISON C. HUNT ◽  
SAMANTHA C. WILLIAMS ◽  
PAUL J. DAVIS ◽  
R. ANDREW BADLEY
Keyword(s):  
Phage Display ◽  
Epitope Mapping ◽  
Peptide Library ◽  
Phage Display Peptide Library ◽  
Alpha Lactalbumin

scholarly journals Epitope Mapping of Metuximab on CD147 Using Phage Display and Molecular Docking

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Bifang He ◽  
Canquan Mao ◽  
Beibei Ru ◽  
Hesong Han ◽  
Peng Zhou ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Phage Display ◽  
Epitope Mapping ◽  
Bioinformatics Analysis ◽  
Conformational Epitope ◽  
Peptide Library ◽  
Docking Result ◽  
Structural Mechanism ◽  
Phage Display Peptide Library ◽  
Docking Model

Metuximab is the generic name of Licartin, a new drug for radioimmunotherapy of hepatocellular carcinoma. Although it is known to be a mouse monoclonal antibody against CD147, the complete epitope mediating the binding of metuximab to CD147 remains unknown. We panned the Ph.D.-12 phage display peptide library against metuximab and got six mimotopes. The following bioinformatics analysis based on mimotopes suggested that metuximab recognizes a conformational epitope composed of more than 20 residues. The residues of its epitope may include T28, V30, K36, L38, K57, F74, D77, S78, D79, D80, Q81, G83, S86, N98, Q100, L101, H102, G103, P104, V131, P132, and K191. The homology modeling of metuximab and the docking of CD147 to metuximab were also performed. Based on the top one docking model, the epitope was predicted to contain 28 residues: AGTVFTTV (23–30), I37, D45, E84, V88, EPMGTANIQLH (92–102), VPP (131–133), Q164, and K191. Almost half of the residues predicted on the basis of mimotope analysis also appear in the docking result, indicating that both results are reliable. As the predicted epitopes of metuximab largely overlap with interfaces of CD147-CD147 interactions, a structural mechanism of metuximab is proposed as blocking the formation of CD147 dimer.

Identification of rabies virus mimotopes screened from a phage display peptide library with purified dog anti-rabies virus serum IgG

2013 ◽  
Vol 174 (1-2) ◽  
pp. 47-51 ◽  
Author(s):  
Limin Yang ◽  
Junyu Cen ◽  
Qinghua Xue ◽  
Jing Li ◽  
Yuhai Bi ◽  
...  
Keyword(s):  
Phage Display ◽  
Rabies Virus ◽  
Peptide Library ◽  
Phage Display Peptide Library ◽  
Serum Igg

Identification of PSA peptide mimotopes using phage display peptide library

Peptides ◽  
2011 ◽  
Vol 32 (6) ◽  
pp. 1097-1102 ◽  
Author(s):  
Arulkumaran Shanmugam ◽  
Robert Suriano ◽  
Devyani Chaudhuri ◽  
Shilpi Rajoria ◽  
Andrea George ◽  
...  
Keyword(s):  
Phage Display ◽  
Peptide Library ◽  
Phage Display Peptide Library ◽  
Peptide Mimotopes

A synthetic peptide with estrogen-like activity derived from a phage-display peptide library

Peptides ◽  
2002 ◽  
Vol 23 (3) ◽  
pp. 573-580 ◽  
Author(s):  
Natarajan Venkatesh ◽  
Yehudith Zaltsman ◽  
Dalia Somjen ◽  
Batya Gayer ◽  
Ettickan Boopathi ◽  
...  
Keyword(s):  
Phage Display ◽  
Synthetic Peptide ◽  
Peptide Library ◽  
Phage Display Peptide Library

Identification of antigenic epitopes of the SapA protein of Campylobacter fetus using a phage display peptide library

2012 ◽  
Vol 93 (3) ◽  
pp. 1274-1280
Author(s):  
Hailing Zhao ◽  
Shenye Yu ◽  
Huifang Liu ◽  
Wei Si ◽  
Chunlai Wang ◽  
...  
Keyword(s):  
Phage Display ◽  
Peptide Library ◽  
Phage Display Peptide Library ◽  
Campylobacter Fetus ◽  
Antigenic Epitopes
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