Insulin Molecule

2007 ◽  
Keyword(s):  
Insulin Molecule

THE STRUCTURE OF THE INSULIN MOLECULE

Science ◽  
1938 ◽  
Vol 88 (2276) ◽  
pp. 148-149 ◽  
Author(s):  
D. M. Wrinch
Keyword(s):  
Insulin Molecule

Degradation of Insulin-I131 by an Extract of Anterior Pituitary Gland

1958 ◽  
Vol 193 (3) ◽  
pp. 476-478 ◽  
Author(s):  
H. T. Narahara ◽  
R. H. Williams
Keyword(s):  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Trichloroacetic Acid ◽  
Electrophoretic Analysis ◽  
Anterior Pituitary Gland ◽  
Radioactive Material ◽  
Incubation Mixture ◽  
Pituitary Extract ◽  
Insulin Molecule

When insulin-I131 was incubated at 37°C and pH 7.5 with an extract of beef anterior pituitary, the radioactive material was rendered more soluble in trichloroacetic acid (TCA). Electrophoretic analysis of the TCA-soluble reaction product revealed that it was not free iodide. The concept that pituitary extract might contain a system capable of attacking the insulin molecule was strengthened by the observation that the addition of nonlabeled insulin to the incubation mixture decreased the rate of degradation of insulin-I131. The degradative system of beef anterior pituitary extract was found to be nondialyzable and heat-labile. The degradation of insulin by pituitary extracts may help to explain the observation of other workers that such extracts can inactivate insulin in vitro.

Patterson Projection of the Skeletons of the Structure proposed for the Insulin Molecule

Nature ◽  
1940 ◽  
Vol 145 (3687) ◽  
pp. 1018-1018 ◽  
Author(s):  
DOROTHY WRINCH
Keyword(s):  
Insulin Molecule

Evidence for Separate Handling In Vivo of Different Regions of the Insulin Molecule Using A14- and B1-labeled Insulin Tracers

Diabetes ◽  
1984 ◽  
Vol 33 (8) ◽  
pp. 721-727 ◽  
Author(s):  
C. S. Cockram ◽  
R. H. Jones ◽  
M. A. Boroujerdi ◽  
P. H. Sonksen
Keyword(s):  
Insulin Molecule

Molecular characterization of the epitope recognized by mAb 19 on the human insulin molecule

Peptides 1994 ◽  
1995 ◽  
pp. 833-834
Author(s):  
F. Molina ◽  
S. Allauzen ◽  
B. Pau ◽  
M. Bouanani ◽  
C. Granier
Keyword(s):  
Molecular Characterization ◽  
Human Insulin ◽  
Insulin Molecule

Evidence for separate handling in vivo of different regions of the insulin molecule using A14- and B1-labeled insulin tracers

Diabetes ◽  
1984 ◽  
Vol 33 (8) ◽  
pp. 721-727 ◽  
Author(s):  
C. S. Cockram ◽  
R. H. Jones ◽  
M. A. Boroujerdi ◽  
P. H. Sonksen
Keyword(s):  
Insulin Molecule

The Structure of the Insulin Molecule

1938 ◽  
Vol 60 (9) ◽  
pp. 2247-2255 ◽  
Author(s):  
D. M. Wrinch ◽  
Irving Langmuir
Keyword(s):  
Insulin Molecule

X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule

1991 ◽  
Vol 220 (2) ◽  
pp. 425-433 ◽  
Author(s):  
U. Derewenda ◽  
Z. Derewenda ◽  
E.J. Dodson ◽  
G.G. Dodson ◽  
Xiao Bing ◽  
...  
Keyword(s):  
Single Chain ◽  
X Ray ◽  
Insulin Molecule
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