Biological Effects of Various Solvent Fractions Derived from Jeju Island Red Sea Cucumber (Stichopus japonicus)

2011 ◽  
Vol 54 (5) ◽  
pp. 718-724 ◽  
Author(s):  
Soo-Yeong Park
Keyword(s):  
Red Sea ◽  
Sea Cucumber ◽  
Biological Effects ◽  
Jeju Island ◽  
Stichopus Japonicus ◽  
Red Sea Cucumber

Biological effects of various solvent fractions derived from Jeju Island red sea cucumber (Stichopus japonicas)

2011 ◽  
Vol 54 (5) ◽  
pp. 718-724 ◽  
Author(s):  
Soo-Yeong Park ◽  
Hee Kyoung Lim ◽  
Seogjae Lee ◽  
Somi Kim Cho ◽  
Sanggyu Park ◽  
...  
Keyword(s):  
Red Sea ◽  
Sea Cucumber ◽  
Biological Effects ◽  
Jeju Island ◽  
Red Sea Cucumber

Effect of Korean Red Sea Cucumber (Stichopus japonicus) on Melanogenic Protein Expression in Murine B16 Melanoma

2009 ◽  
Vol 6 (1) ◽  
pp. 37-42 ◽  
Author(s):  
W.J. Yoon ◽  
M.J. Kim ◽  
H.B. Koh ◽  
W.J. Lee ◽  
N.H. Lee ◽  
...  
Keyword(s):  
Protein Expression ◽  
Red Sea ◽  
Sea Cucumber ◽  
B16 Melanoma ◽  
Stichopus Japonicus ◽  
Red Sea Cucumber

Pepsin-solubilised collagen (PSC) from Red Sea cucumber (Stichopus japonicus) regulates cell cycle and the fibronectin synthesis in HaCaT cell migration

2012 ◽  
Vol 132 (1) ◽  
pp. 487-492 ◽  
Author(s):  
Soo-Yeong Park ◽  
Hee Kyoung Lim ◽  
Seogjae Lee ◽  
Hyeong Cheol Hwang ◽  
Somi K. Cho ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Migration ◽  
Red Sea ◽  
Sea Cucumber ◽  
Hacat Cell ◽  
Stichopus Japonicus ◽  
Red Sea Cucumber

scholarly journals Quality and Preference Changes Red Sea Cucumber (Stichopus japonicus) Kimchi during Storage Period

2012 ◽  
Vol 55 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Soo-Yeong Park ◽  
Hee-Kyoung Lim ◽  
Sang-Gyu Park ◽  
Moon-Jae Cho
Keyword(s):  
Red Sea ◽  
Sea Cucumber ◽  
Storage Period ◽  
Stichopus Japonicus ◽  
Red Sea Cucumber

scholarly journals Holospiniferoside: A New Antitumor Cerebroside from The Red Sea Cucumber Holothuria spinifera: In Vitro and In Silico Studies

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1555
Author(s):  
Enas E. Eltamany ◽  
Usama Ramadan Abdelmohsen ◽  
Dina M. Hal ◽  
Amany K. Ibrahim ◽  
Hashim A. Hassanean ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Red Sea ◽  
Active Site ◽  
Sea Cucumber ◽  
Gas Chromatography Mass Spectrometry ◽  
Spectrometric Analysis ◽  
Chemical Structures ◽  
In Silico Studies ◽  
Red Sea Cucumber

Chemical investigation of the methanolic extract of the Red Sea cucumber Holothuria spinifera led to the isolation of a new cerebroside, holospiniferoside (1), together with thymidine (2), methyl-α-d-glucopyranoside (3), a new triacylglycerol (4), and cholesterol (5). Their chemical structures were established by NMR and mass spectrometric analysis, including gas chromatography–mass spectrometry (GC–MS) and high-resolution mass spectrometry (HRMS). All the isolated compounds are reported in this species for the first time. Moreover, compound 1 exhibited promising in vitro antiproliferative effect on the human breast cancer cell line (MCF-7) with IC50 of 20.6 µM compared to the IC50 of 15.3 µM for the drug cisplatin. To predict the possible mechanism underlying the cytotoxicity of compound 1, a docking study was performed to elucidate its binding interactions with the active site of the protein Mdm2–p53. Compound 1 displayed an apoptotic activity via strong interaction with the active site of the target protein. This study highlights the importance of marine natural products in the design of new anticancer agents.

scholarly journals New Cytotoxic Cerebrosides from the Red Sea Cucumber Holothuria spinifera Supported by In-Silico Studies

Marine Drugs ◽  
2020 ◽  
Vol 18 (8) ◽  
pp. 405
Author(s):  
Reda F. A. Abdelhameed ◽  
Enas E. Eltamany ◽  
Dina M. Hal ◽  
Amany K. Ibrahim ◽  
Asmaa M. AboulMagd ◽  
...  
Keyword(s):  
Red Sea ◽  
Sea Cucumber ◽  
Breast Adenocarcinoma ◽  
Cytotoxic Activities ◽  
Cholesterol Sulfate ◽  
Standard Drug ◽  
Chemical Structures ◽  
In Silico Studies ◽  
Red Sea Cucumber ◽  
Mcf 7

Bioactivity-guided fractionation of a methanolic extract of the Red Sea cucumber Holothuria spinifera and LC-HRESIMS-assisted dereplication resulted in the isolation of four compounds, three new cerebrosides, spiniferosides A (1), B (2), and C (3), and cholesterol sulfate (4). The chemical structures of the isolated compounds were established on the basis of their 1D NMR and HRMS spectral data. Metabolic profiling of the H. spinifera extract indicated the presence of diverse secondary metabolites, mostly hydroxy fatty acids, diterpenes, triterpenes, and cerebrosides. The isolated compounds were tested for their in vitro cytotoxicities against the breast adenocarcinoma MCF-7 cell line. Compounds 1, 2, 3, and 4 displayed promising cytotoxic activities against MCF-7 cells, with IC50 values of 13.83, 8.13, 8.27, and 35.56 µM, respectively, compared to that of the standard drug doxorubicin (IC50 8.64 µM). Additionally, docking studies were performed for compounds 1, 2, 3, and 4 to elucidate their binding interactions with the active site of the SET protein, an inhibitor of protein phosphatase 2A (PP2A), which could explain their cytotoxic activity. This study highlights the important role of these metabolites in the defense mechanism of the sea cucumber against fouling organisms and the potential uses of these active molecules in the design of new anticancer agents.

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