Quinone Reductase Inductive Activity of Capsicum annuum Leaves and Isolation of the Active Compounds

2010 ◽  
Vol 53 (6) ◽  
pp. 709-715 ◽  
Author(s):  
Kang Mo Ku
Keyword(s):  
Capsicum Annuum ◽  
Quinone Reductase ◽  
Active Compounds ◽  
Inductive Activity

scholarly journals The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations

1991 ◽  
Vol 273 (3) ◽  
pp. 711-717 ◽  
Author(s):  
S R Spencer ◽  
L A Xue ◽  
E M Klenz ◽  
P Talalay
Keyword(s):  
Molecular Mechanisms ◽  
Glutathione Transferase ◽  
Quinone Reductase ◽  
Detoxification Enzymes ◽  
Glutathione Transferases ◽  
Methyl Cinnamate ◽  
Major Mechanism ◽  
Electronic Densities ◽  
Quinone Acceptor ◽  
Inductive Activity

Induction of glutathione transferases (EC. 2.5.1.18), NAD(P)H:(quinone-acceptor) oxidoreductase (EC 1.6.99.2; quinone reductase) and other detoxification enzymes is a major mechanism for protecting cells against the toxicities of electrophiles, including many carcinogens. Although inducers of these two enzymes belong to many different chemical classes, they nevertheless contain (or acquire by metabolism) electrophilic centres that appear to be essential for inclusive activity, and many inducers are Michael reaction acceptors [Talalay, De Long & Prochaska (1988) Proc. Natl. Acad. Sci. U.S.A., 85, 8261-8265]. The inducers therefore share structural and electronic features with glutathione transferase substrates. To define these features more precisely, we examined the inductive potencies (by measuring quinone reductase in murine hepatoma cells) of two types of glutathione transferase substrates: a series of 1-chloro-2-nitrobenzenes bearing para-oriented electron-donating or -withdrawing substituents and a wide variety of other commonly used and structurally unrelated glutathione transferase substrates. We conclude that virtually all glutathione transferase substrates are inducers, and their potencies in the nitrobenzene series correlate linearly with the Hammett sigma or sigma- values of the aromatic substituents, precisely as previously reported for their efficiencies as glutathione transferase substrates. More detailed information on the electronic requirements for inductive activity was obtained with a series of methyl trans-cinnamates bearing electron-withdrawing or -donating substituents on the aromatic ring, and in which the electronic densities at the olefinic and adjacent carbon atoms were measured by 13C n.m.r. Electron-withdrawing meta-substituents markedly enhance inductive potency in parallel with their increased non-enzymic reactivity with GSH. Thus, methyl 3-bromo-, 3-nitro- and 3-chloro-cinnamates are 21, 14 and 8 times more potent inducers than the parent methyl cinnamate. This finding permits the design of more potent inducers, which are important for elucidation of the molecular mechanisms of induction.

Bioguided fractionation of the antimalarial plant Argemone mexicana: isolation and quantification of active compounds from effective clinical batches

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
CA Simões-Pires ◽  
EA Diop ◽  
JR Ioset ◽  
J Falquet ◽  
A Matheeussen ◽  
...  
Keyword(s):  
Argemone Mexicana ◽  
Active Compounds

Anthraquinones with potent quinone reductase-inducing activity from the stem bark of Morinda citrifolia (Rubiaceae)

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
R Ho ◽  
O Ciclet ◽  
A Ben Zaied ◽  
P Raharivelomanana ◽  
M Cuendet
Keyword(s):  
Stem Bark ◽  
Quinone Reductase ◽  
Morinda Citrifolia

Screening of some Asteraceae to discover new active compounds against Trypanosoma brucei by metabolite profiling and PLS analysis

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
MS Nogueira ◽  
FB da Costa ◽  
MA Magenta ◽  
M Kaiser ◽  
R Brun ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Metabolite Profiling ◽  
Active Compounds ◽  
Pls Analysis
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