A Lipid-Soluble Ginseng Extract Inhibits Human Large Cell Lung Cancer (NCI-H460) Cells Xenograft In Vivo and the Proliferation of Cancer Cells In Vitro

2010 ◽  
Vol 53 (3) ◽  
pp. 375-378 ◽  
Author(s):  
Eun Sil Lee
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Large Cell ◽  
Ginseng Extract ◽  
H460 Cells ◽  
Large Cell Lung Cancer

scholarly journals ABCG2-overexpressing H460/MX20 cell xenografts in athymic nude mice maintained original biochemical and cytological characteristics

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Wei Zhang ◽  
Zhen Chen ◽  
Likun Chen ◽  
Fang Wang ◽  
Furong Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Nude Mice ◽  
Large Cell ◽  
Athymic Nude Mice ◽  
H460 Cell ◽  
Large Cell Lung Cancer ◽  
Cytological Characteristics

Abstract H460/MX20 are derived from large cell lung cancer H460 cell line and then transformed into ABCG2-overexpressing cells by mitoxantrone’s induction, which are widely used in study of multidrug resistance (MDR) in vitro. To establish and spread the model of H460/MX20 cell xenografts, we investigated whether cell biological characteristics and the MDR phenotype were maintained in vivo model. Our results demonstrated that the cell proliferation, cell cycle, and ABCG2 expression level in xH460/MX20 cells isolated from H460/MX20 cell xenografts were similar to H460/MX20 cells in vitro. Importantly, xH460/MX20 cells exhibited high levels of resistance to ABCG2 substrates such as mitoxantrone and topotecan as H460/MX20 cells did. Furthermore, lapatinib, the inhibitor of ABCG2, potently reversed mitoxantrone- and topotecan-resistance of xH460/MX20 cells. Taken together, these results suggest that H460/MX20 cell xenografts in athymic nude mice still retain their original cytological characteristics and MDR phenotype. Thus, the H460/MX20 cell xenografts model could serve as a sound model in vivo for study on reversal MDR.

scholarly journals The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer

2009 ◽  
Vol 8 (8) ◽  
pp. 2221-2231 ◽  
Author(s):  
M. Cecilia Crisanti ◽  
Africa F. Wallace ◽  
Veena Kapoor ◽  
Fabian Vandermeers ◽  
Melissa L. Dowling ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Hdac Inhibitor ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung

Tricarbonylrhenium(i) complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer

2016 ◽  
Vol 40 (9) ◽  
pp. 7379-7387 ◽  
Author(s):  
Camila Vargas Garcia ◽  
Gabrieli Lessa Parrilha ◽  
Bernardo Lages Rodrigues ◽  
Sarah Fernandes Teixeira ◽  
Ricardo Alexandre de Azevedo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lung Cancer ◽  
Antiproliferative Activity ◽  
Mode Of Action ◽  
Large Cell ◽  
H460 Cells ◽  
Large Cell Lung Cancer ◽  
Hydrazone Complexes

Tricarbonylrhenium(i)-hydrazone complexes showed antiproliferative activity against NCI-H460 cells. The mode of action involves apoptosis and ROS scavenge.

scholarly journals Irradiation Decreases the Neuroendocrine Biomarker Pro-Opiomelanocortin in Small Cell Lung Cancer Cells In Vitro and In Vivo

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0148404 ◽  
Author(s):  
Suzanne L. Meredith ◽  
Jennifer L. Bryant ◽  
Muhammad Babur ◽  
Philip W. Riddell ◽  
Roya Behrouzi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung
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