Effect of Sophora japonica Extract on Lipid Content in High Fat Diet Fed Rats

2009 ◽  
Vol 52 (2) ◽  
pp. 133-138
Author(s):  
Byung-Yong Ahn
Keyword(s):  
Lipid Content ◽  
High Fat Diet ◽  
High Fat ◽  
Sophora Japonica

scholarly journals Antiobesity Effect ofAstilbe chinensisFranch. et Savet. Extract through Regulation of Adipogenesis and AMP-Activated Protein Kinase Pathways in 3T3-L1 Adipocyte and High-Fat Diet-Induced C57BL/6N Obese Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Xian Hua Zhang ◽  
Zhiqiang Wang ◽  
Bueom-Goo Kang ◽  
Seung Hwan Hwang ◽  
Jae-Young Lee ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Lipid Content ◽  
High Fat Diet ◽  
Binding Protein ◽  
Resistance Index ◽  
Nonesterified Fatty Acid ◽  
Dependent Manner ◽  
Obese Mice ◽  
High Fat ◽  
Amp Activated Protein Kinase

Astilbe chinensisFranch. et Savat. (AC) has been used in traditional medicine for the treatment of chronic bronchitis, arthralgia, and gastralgia. In this study, we investigated the antiobesity effect of AC extract on 3T3-L1 preadipocytes and high-fat-diet-fed C57BL/6N obese mice. We found that AC extracts dramatically decreased the lipid content of 3T3-L1 cells in a concentration-dependent manner without cytotoxicity. The action mechanism of AC extract was demonstrated to be the inhibition of lipid accumulation and dose-dependent decrease in the expression of CCAAT/enhancer-binding proteinα(C/EBPα), peroxisome proliferator-activated receptor-γ(PPAR-γ), and sterol regulatory element-binding protein 1 (SREBP1). Furthermore, AC extract increased the mitochondrial phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC), mitochondrial biogenesis, and lipolysis-related factors. In amice model of high-fat-diet-induced obesity, the mice administered AC extract experienced significant decrease of 64% in weight gain, 55% in insulin resistance index, 22% in plasma triglycerides (TG), 56% in total cholesterol (TC), and 21% in nonesterified fatty acid (NEFA) levels compared with those in the high-fat diet-fed control mice. Collectively, these results indicated that AC extract exerted antiobesogenic activity through the modulation of the AMPK signaling pathway, inhibition of adipogenesis, decreased lipid content, and reduced adipocyte size.

scholarly journals Liver size and lipid content differences between BALB/c and BALB/cJ mice on a high-fat diet are due, in part, to Zhx2

2019 ◽  
Vol 30 (7-8) ◽  
pp. 226-236 ◽  
Author(s):  
Erica L. Clinkenbeard ◽  
Courtney Turpin ◽  
Jieyun Jiang ◽  
Martha L. Peterson ◽  
Brett T. Spear
Keyword(s):  
Lipid Content ◽  
High Fat Diet ◽  
High Fat ◽  
Liver Size

scholarly journals Intramyocellular Lipid Content and Molecular Adaptations in Response to a 1-Week High-Fat Diet

2005 ◽  
Vol 13 (12) ◽  
pp. 2088-2094 ◽  
Author(s):  
Vera B. Schrauwen-Hinderling ◽  
Marianne Eline Kooi ◽  
Matthijs K.C. Hesselink ◽  
Esther Moonen-Kornips ◽  
Gert Schaart ◽  
...  
Keyword(s):  
Lipid Content ◽  
High Fat Diet ◽  
Intramyocellular Lipid ◽  
High Fat ◽  
Intramyocellular Lipid Content

scholarly journals Fat absorption and deposition in Japanese quail (Coturnix coturnix japonica) fed a high fat diet

2013 ◽  
Vol 84 (1) ◽  
Author(s):  
Mhlengi M. Magubane ◽  
Busisani W. Lembede ◽  
Kennedy H. Erlwanger ◽  
Eliton Chivandi ◽  
Janine Donaldson
Keyword(s):  
Japanese Quail ◽  
Lipid Content ◽  
High Fat Diet ◽  
Lipid Absorption ◽  
Thigh Muscle ◽  
Standard Diet ◽  
High Fat ◽  
Muscle Lipid ◽  
Coturnix Coturnix ◽  
Female Quail

Dietary fat contributes significantly to the energy requirements of poultry. Not all species are able to increase their absorptive capacity for fats in response to a high fat diet. The effects of a high fat diet (10% canola oil) on the lipid absorption and deposition in the liver, breast and thigh muscles of male and female Japanese quail were investigated. Thirty-eight Japanese quail (Coturnix coturnix japonica) were randomly divided into a high fat diet (HFD) and a standard diet (STD) group. The birds were fed the diets for seven weeks after which half of the birds were subjected to oral fat loading tests (OFLT) with plant oils containing long-chain and medium-chain triglycerides. The remaining birds were included for the lipid deposition measurements. Thereafter the birds were euthanised, blood samples were collected and liver, breast and thigh muscle lipid deposition was determined. Female quail on both diets had significantly higher plasma triglyceride concentrations (p < 0.05) compared with their male counterparts. No significant differences in plasma triglyceride concentrations were observed after the OFLTs. Female quail had significantly heavier liver masses compared with the males but there was no significant difference in the liver lipid content per gram liver mass. Female quail on the HFD had higher lipid content (p < 0.05) in the breast muscle compared with their male counterparts whilst male quail on the HFD had higher lipid content (p < 0.05) in the thigh muscle in comparison with both males and females on the standard diet. Dietary supplementation with 10% canola oil did not alter gastrointestinal tract lipid absorption, but it caused differences between the sexes in muscle lipid accumulation, the physiological significance of which requires further investigation.

scholarly journals Diet during early life defines testicular lipid content and sperm quality in adulthood

2020 ◽  
Vol 319 (6) ◽  
pp. E1061-E1073
Author(s):  
Luís Crisóstomo ◽  
Romeu A. Videira ◽  
Ivana Jarak ◽  
Kristina Starčević ◽  
Tomislav Mašek ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Lipid Content ◽  
High Fat Diet ◽  
Early Life ◽  
Sperm Quality ◽  
Early Adulthood ◽  
Sperm Parameters ◽  
Chow Diet ◽  
High Fat ◽  
Permanent Damage

Childhood obesity is a serious concern associated with ill health later in life. Emerging data suggest that obesity has long-term adverse effects upon male sexual and reproductive health, but few studies have addressed this issue. We hypothesized that exposure to high-fat diet during early life alters testicular lipid content and metabolism, leading to permanent damage to sperm parameters. After weaning ( day 21 after birth), 36 male mice were randomly divided into three groups and fed with a different diet regimen for 200 days: a standard chow diet (CTRL), a high-fat diet (HFD) (carbohydrate: 35.7%, protein: 20.5%, and fat: 36.0%), and a high-fat diet for 60 days, then replaced by standard chow (HFDt). Biometric and metabolic data were monitored. Animals were then euthanized, and tissues were collected. Epididymal sperm parameters and endocrine parameters were evaluated. Testicular metabolites were extracted and characterized by 1H-NMR and GC-MS. Testicular mitochondrial and antioxidant activity were evaluated. Our results show that mice fed with a high-fat diet, even if only until early adulthood, had lower sperm viability and motility, and higher incidence of head and tail defects. Although diet reversion with weight loss during adulthood prevents the progression of metabolic syndrome, testicular content in fatty acids is irreversibly affected. Excessive fat intake promoted an overaccumulation of proinflammatory n-6 polyunsaturated fatty acids in the testis, which is strongly correlated with negative effects upon sperm quality. Therefore, the adoption of high-fat diets during early life correlates with irreversible changes in testicular lipid content and metabolism, which are related to permanent damage to sperm quality later in life.

Sign in / Sign up

Export Citation Format

Share Document