scholarly journals Autophagy-enhancing and neuroprotective effects of Wonji-Gobon mixture (WGM) in a Parkinson’s disease mouse model

2018 ◽  
Vol 61 (4) ◽  
pp. 341-349
Author(s):  
Jin-Wook Lee ◽  
Jin-Young Kwak ◽  
Young-Mee Koh ◽  
Taek-Won Ahn
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Neuroprotective Effects

Neuroprotective Effects of a GLP-2 Analogue in the MPTP Parkinson’s Disease Mouse Model

2021 ◽  
pp. 1-15
Author(s):  
Zijuan Zhang ◽  
Li Hao ◽  
Ming Shi ◽  
Ziyang Yu ◽  
Simai Shao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Mouse Model ◽  
Neurodegenerative Disorder ◽  
Enzyme Linked Immunosorbent Assay ◽  
Protective Effects ◽  
Neuroprotective Effects ◽  
Expression Levels ◽  
Dual Agonist

Background: Glucagon-like peptide 2 (GLP-2) is a peptide hormone derived from the proglucagon gene expressed in the intestines, pancreas and brain. Some previous studies showed that GLP-2 improved aging and Alzheimer’s disease related memory impairments. Parkinson’s disease (PD) is a progressive neurodegenerative disorder, and to date, there is no particular medicine reversed PD symptoms effectively. Objective: The aim of this study was to evaluate neuroprotective effects of a GLP-2 analogue in the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) PD mouse model. Methods: In the present study, the protease resistant Gly(2)-GLP-2 (50 nmol/kg ip.) analogue has been tested for 14 days by behavioral assessment, transmission electron microscope, immunofluorescence histochemistry, enzyme-linked immunosorbent assay and western blot in an acute PD mouse model induced by MPTP. For comparison, the incretin receptor dual agonist DA5-CH was tested in a separate group. Results: The GLP-2 analogue treatment improved the locomotor and exploratory activity of mice, and improved bradykinesia and movement imbalance of mice. Gly(2)-GLP-2 treatment also protected dopaminergic neurons and restored tyrosine hydroxylase expression levels in the substantia nigra. Gly(2)-GLP-2 furthermore reduced the inflammation response as seen in lower microglia activation, and decreased NLRP3 and interleukin-1β pro-inflammatory cytokine expression levels. In addition, the GLP-2 analogue improved MPTP-induced mitochondrial dysfunction in the substantia nigra. The protective effects were comparable to those of the dual agonist DA5-CH. Conclusion: The present results demonstrate that Gly(2)-GLP-2 can attenuate NLRP3 inflammasome-mediated inflammation and mitochondrial damage in the substantia nigra induced by MPTP, and Gly(2)-GLP-2 shows neuroprotective effects in this PD animal model.

Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T α-synuclein mouse model of Parkinson's disease

2018 ◽  
Vol 9 (12) ◽  
pp. 6414-6426 ◽  
Author(s):  
Li-fan Zhang ◽  
Xiao-lin Yu ◽  
Mei Ji ◽  
Shu-ying Liu ◽  
Xiao-ling Wu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Cognitive Deficits ◽  
Neuroprotective Effects

Resveratrol exerts neuroprotective effects on the A53T α-synuclein mouse model of Parkinson's disease.

Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease

2015 ◽  
Vol 765 ◽  
pp. 284-290 ◽  
Author(s):  
WeiZhen Liu ◽  
Yanwei Li ◽  
Jaishree Jalewa ◽  
Taylor Saunders-Wood ◽  
Lin Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Neuroprotective Effects

scholarly journals GDNF-Transfected Macrophages Produce Potent Neuroprotective Effects in Parkinson's Disease Mouse Model

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e106867 ◽  
Author(s):  
Yuling Zhao ◽  
Matthew J. Haney ◽  
Richa Gupta ◽  
John P. Bohnsack ◽  
Zhijian He ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Neuroprotective Effects

Neuroprotective effects of alkaloids fromPiper longumin a MPTP-induced mouse model of Parkinson’s disease

2015 ◽  
Vol 53 (10) ◽  
pp. 1516-1524 ◽  
Author(s):  
Ying Bi ◽  
Peng-Cheng Qu ◽  
Qing-Song Wang ◽  
Li Zheng ◽  
Hao-Long Liu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Neuroprotective Effects
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