scholarly journals Erratum to: Single- and repeated-dose oral toxicity tests of deep sea water mineral extracts in ICR mice

2016 ◽  
Vol 59 (4) ◽  
pp. 379-379
Author(s):  
Min Hee Hwang ◽  
Miju Cho ◽  
Dong Gun Lee ◽  
Eun Byeol Go ◽  
Young Sig Park ◽  
...  
Keyword(s):  
Deep Sea ◽  
Sea Water ◽  
Repeated Dose ◽  
Toxicity Tests ◽  
Oral Toxicity ◽  
Deep Sea Water ◽  
Icr Mice ◽  
Dose Oral

scholarly journals Single- and repeated-dose oral toxicity tests of deep sea water mineral extracts in ICR mice

2016 ◽  
Vol 59 (3) ◽  
pp. 227-231 ◽  
Author(s):  
Min Hee Hwang ◽  
Miju Cho ◽  
Dong Gun Lee ◽  
Eun Byeol Go ◽  
Young Sig Park ◽  
...  
Keyword(s):  
Deep Sea ◽  
Sea Water ◽  
Repeated Dose ◽  
Toxicity Tests ◽  
Oral Toxicity ◽  
Deep Sea Water ◽  
Icr Mice ◽  
Dose Oral

scholarly journals Safety evaluation of Bifidobacterium breve MCC1274 via oral toxicity tests in rats

2018 ◽  
Vol 2 ◽  
pp. 239784731880737
Author(s):  
Satoshi Arai ◽  
Jun-ichi Minami ◽  
Masamichi Muto ◽  
Noriyuki Iwabuchi ◽  
Koji Yamauchi ◽  
...  
Keyword(s):  
Single Dose ◽  
Daily Intake ◽  
Clinical Signs ◽  
Blood Chemistry ◽  
Repeated Dose ◽  
Toxicity Tests ◽  
Control Group ◽  
Oral Toxicity ◽  
Bifidobacterium Breve ◽  
Dose Oral

In this study, the safety of Bifidobacterium breve MCC1274, a probiotic bifidobacterial strain, was assessed by single-dose and 90-day repeated-dose oral toxicity studies. In the single-dose oral toxicity assay using 6000 mg/kg of B. breve MCC1274 corresponding to 8.4 × 1011 colony-forming unit (CFU)/kg, mortality and adverse effects were not observed. Furthermore, the administration of 1000 mg/kg of B. breve MCC1274 by oral gavage in saline for 90 days did not induce any signs of toxicity, such as changes in clinical signs, body weight (BW), food consumption, ophthalmoscopy, urinalysis, hematology, blood chemistry, organ weight, gross pathology, and histopathology compared to the control group given cornstarch in saline (10/sex/group). The no-observed-adverse-effect-level of B. breve MCC1274 in the 90-day repeated-dose toxicity study was greater than 1000 mg/kg corresponding to 1.3 × 1011 CFU/kg. Based on the findings of this study, the acceptable daily intake of B. breve MCC1274 was calculated to be 1.3 × 109 CFU/kg BW/day.

scholarly journals 3-week repeated dose oral toxicity study of Clausena excavata extract in ICR mice

2019 ◽  
Vol 62 (2) ◽  
pp. 123-127
Author(s):  
Ju-Hyoung Park ◽  
Young-Rak Cho ◽  
Young Min Kim ◽  
Jae-Shin Kang ◽  
Joa Sub Oh ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Oral Toxicity ◽  
Icr Mice ◽  
Dose Oral

scholarly journals Pararhodobacter marinus sp. nov., isolated from deep-sea water of the Indian Ocean

2019 ◽  
Vol 69 (4) ◽  
pp. 932-936 ◽  
Author(s):  
Qiliang Lai ◽  
Xiupian Liu ◽  
Jun Yuan ◽  
Shuchen Xie ◽  
Zongze Shao
Keyword(s):  
Indian Ocean ◽  
Deep Sea ◽  
Type Species ◽  
Sea Water ◽  
Rrna Gene ◽  
Chromosomal Dna ◽  
Content Type ◽  
Deep Sea Water ◽  
Link Type ◽  
The Indian Ocean

A taxonomic study was carried out on strain CIC4N-9T, which was isolated from deep-sea water of the Indian Ocean. The bacterium was Gram-stain-negative, catalase- and oxidase-positive, rod-shaped and non-motile. Growth was observed at salinities of 0–9% and at temperatures of 4–41 °C. The isolate was able to degrade gelatin but not aesculin. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain CIC4N-9T belonged to the genus Pararhodobacter , with the highest sequence similarity to the only recognized species, Pararhodobacter aggregans D1-19T (96.9 %). The average nucleotide identity and estimated DNA–DNA hybridization values between strain CIC4N-9T and P. aggregans D1-19T were 80.4 and 23.0 %, respectively. The principal fatty acids were summed feature 8 (C18 : 1 ω7c and/or C18 : 1 ω6c), C16 : 0, C18 : 1ω7c 11-methyl, C18 : 0 and C17 : 0. The G+C content of the chromosomal DNA was 66.8 mol%. The sole respiratory quinone was determined to be Q-10. Phosphatidylcholine, phosphatidylglycerol, phosphatidylethanolamine, diphosphatidylglycerol, two unknown phospholipids, four unknown aminolipids and one unknown polar lipid were present. The combined genotypic and phenotypic data show that strain CIC4N-9T represents a novel species within the genus Pararhodobacter , for which the name Pararhodobacter marinus sp. nov. is proposed. The type strain is CIC4N-9T (=MCCC 1A01225T=KCTC 52336T).

4-Week repeated dose oral toxicity study of N-ethyl-2-pyrrolidone in Sprague Dawley rats

2016 ◽  
Vol 81 ◽  
pp. 275-283 ◽  
Author(s):  
A.M. Saillenfait ◽  
F. Marquet ◽  
J.P. Sabaté ◽  
D. Ndiaye ◽  
A.M. Lambert-Xolin
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral

scholarly journals Anti-Inflammatory Properties of Mineral-Balanced Deep Sea Water in In-Vitro and In-Vivo Models of Inflamed Intestinal Epithelium

2020 ◽  
Vol 10 (15) ◽  
pp. 5183
Author(s):  
Jain Nam ◽  
Kyeong Jin Kim ◽  
Geonhee Park ◽  
Byeong Goo Kim ◽  
Gwi-Hwa Jeong ◽  
...  
Keyword(s):  
Deep Sea ◽  
Sea Water ◽  
Cell Model ◽  
Mineral Waters ◽  
In Vivo Models ◽  
Deep Sea Water ◽  
High Calcium ◽  
A Cell

This study aimed to determine the effect of deep-sea water (DSW)-derived mineral waters on intestinal health, using a cell model and a dextran sulfate sodium (DSS)-induced enteritis mouse model. DSW was desalted and minerals were added to generate mineral waters that were classified as trace mineral (TM), high magnesium (HM), high magnesium low salt (HMLS), and high magnesium high calcium (HMHC), using a tabletop electrodialysis device. Caco-2 cells cocultured with Raw264.7 cells were either pre-treated or not with the four water groups, and inflammation was induced by treatment with lipopolysaccharide (LPS). Compared to LPS-treated Caco-2 cells, HMLS-cotreated cells maintained high transepithelial electrical resistance, similar to control cells. FITC-dextran permeability was lower in HMLS-treated than in other cells. In vivo, in comparison to DSS-treated mice, colon shortening was inhibited, and disease activity and colon injury were suppressed in HMLS-cotreated mice. RNA-seq of colonic tissues revealed that inflammatory gene expression was similar among the control and HMLS mice, and DSS-induced expression of inflammation-related genes such as TNF-α and NOS2 and inflammatory chemokine genes was suppressed. Our findings suggest that DSW-derived mineral water intake can help reduce colitis symptoms, and the effects may be partially regulated by magnesium and other minerals.

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