scholarly journals Prevalence of Helicobacter pylori resistance to clarithromycin determined by 23S ribosomal RNA analysis in Jordan

10.3823/789 ◽  
2016 ◽  
Author(s):  
Diab AF ◽  
Diab F Hasan ◽  
Nassar SS
Keyword(s):  
Helicobacter Pylori ◽  
Ribosomal Rna ◽  
Rna Analysis ◽  
23S Ribosomal Rna

scholarly journals Helicobacter pylori Eradication According to Sequencing-Based 23S Ribosomal RNA Point Mutation Associated with Clarithromycin Resistance

2019 ◽  
Vol 9 (1) ◽  
pp. 54 ◽  
Author(s):  
Seung In Seo ◽  
Byoung Joo Do ◽  
Jin Gu Kang ◽  
Hyoung Su Kim ◽  
Myoung Kuk Jang ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Point Mutation ◽  
Ribosomal Rna ◽  
Eradication Rate ◽  
Point Mutations ◽  
Clarithromycin Resistance ◽  
Clinically Significant ◽  
H Pylori ◽  
23S Ribosomal Rna ◽  
Significant Point

Background/Aims: Clarithromycin resistance in Helicobacter pylori is associated with point mutations in the 23S ribosomal RNA (rRNA) gene. We investigated the point mutations in the 23S rRNA genes of patients with clarithromycin-resistant H. pylori and compared the H. pylori eradication rates based on the point mutations. Methods: A total of 431 adult patients with H. pylori infection were recruited in Kangdong Sacred Heart Hospital in 2017 and 2018. Patients who did not have point mutations related to clarithromycin resistance and/or had clinically insignificant point mutations were treated with PAC (proton pump inhibitor, amoxicillin, clarithromycin) for seven days, while patients with clinically significant point mutations were treated with PAM (proton pump inhibitor, amoxicillin, metronidazole) for seven days. H. pylori eradication rates were compared. Results: Sequencing-based detection of point mutations identified four mutations that were considered clinically significant (A2142G, A2142C, A2143G, A2143C). The clarithromycin resistance rate was 21.3% in the overall group of patients. A2143G was the most clinically significant point mutation (84/431, 19.5%), while T2182C was the most clinically insignificant point mutation (283/431, 65.7%). The overall H. pylori eradication rate was 83.7%, and the seven-day PAM-treated clarithromycin-resistance group showed a significantly lower eradication rate than the seven-day PAC-treated nonresistance group (ITT; 55.4% (51/92) vs. 74.3% (252/339), p = 0.001, PP; 66.2% (51/77) vs. 88.4% (252/285), p = 0.0001). Conclusions: There were significantly lower eradication rates in the patients with clarithromycin-resistant H. pylori when treated with PAM for seven days. A future study comparing treatment regimens in clarithromycin-resistant H. pylori-infected patients may be necessary.

scholarly journals Eradication of Helicobacter pylori According to 23S Ribosomal RNA Point Mutations Associated With Clarithromycin Resistance

2013 ◽  
Vol 208 (7) ◽  
pp. 1123-1130 ◽  
Author(s):  
H. J. Lee ◽  
J. I. Kim ◽  
D. Y. Cheung ◽  
T. H. Kim ◽  
E. J. Jun ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Ribosomal Rna ◽  
Point Mutations ◽  
Clarithromycin Resistance ◽  
23S Ribosomal Rna

scholarly journals Influence of a 23S ribosomal RNA mutation in Helicobacter pylori strains on the in vitro synergistic effect of clarithromycin and amoxicillin

2012 ◽  
Vol 5 (1) ◽  
Author(s):  
Türkan Sakinc ◽  
Barbara Baars ◽  
Nicole Wüppenhorst ◽  
Manfred Kist ◽  
Johannes Huebner ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Synergistic Effect ◽  
Ribosomal Rna ◽  
23S Ribosomal Rna

Probing 23S Ribosomal RNA Cleavage Sites in Coccoid Helicobacter pylori

Helicobacter ◽  
2001 ◽  
Vol 6 (2) ◽  
pp. 100-109 ◽  
Author(s):  
Hans-Jurg Monstein ◽  
Charlotta D. de la Cour ◽  
Jon Jonasson
Keyword(s):  
Helicobacter Pylori ◽  
Ribosomal Rna ◽  
Rna Cleavage ◽  
Cleavage Sites ◽  
23S Ribosomal Rna

scholarly journals Types of 23S Ribosomal RNA Point Mutations and Therapeutic Outcomes for Helicobacter pylori

Gut and Liver ◽  
2020 ◽  
Author(s):  
Sang Yoon Kim ◽  
Jae Myung Park ◽  
Chul-Hyun Lim ◽  
Hye Ah Lee ◽  
Ga-Yeong Shin ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Ribosomal Rna ◽  
Point Mutations ◽  
Therapeutic Outcomes ◽  
23S Ribosomal Rna

RNase G participates in processing of the 5′-end of 23S ribosomal RNA

2011 ◽  
Vol 49 (3) ◽  
pp. 508-511 ◽  
Author(s):  
Woo-Seok Song ◽  
Minho Lee ◽  
Kangseok Lee
Keyword(s):  
Ribosomal Rna ◽  
23S Ribosomal Rna ◽  
Rnase G
Sign in / Sign up

Export Citation Format

Share Document