scholarly journals The Cardiovascular Involvement In The Zika Virus Infection

10.3823/2579 ◽  
2018 ◽  
Vol 11 ◽  
Author(s):  
Modesto Leite Rolim Neto ◽  
Arthur Rafhael Amorim Alves Esmeraldo ◽  
Dábylla Cynthia Carvalho Bezerra ◽  
Francisca Patricia de Melo Santos Leite ◽  
Cristiano Nogueira Marques ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Virus Infection ◽  
Zika Virus ◽  
Congenital Heart ◽  
Cardiac Involvement ◽  
Clinical Manifestations ◽  
Neurological Complications ◽  
Zika Virus Infection ◽  
Cardiovascular Involvement

The evidences highlight that 13.5% of the echocardiographic studies performed in children with congenital Zika virus infection presented amendments of congenital heart disease (CHD). Several recent studies have shown that the pathogenesis of neurological complications of the Zika virus, as Guillain-Barre Syndrome, in relation to other clinical manifestations there are still no conclusive findings. Scientific studies have observed the possibility of cardiac involvement be underdiagnosed due to the mercy of the infection per ZIKV, in their majority.

The P-MAPA immunomodulator partially prevents apoptosis induced by Zika virus infection in THP-1 cells

2020 ◽  
Vol 21 ◽  
Author(s):  
Morganna C. Lima ◽  
Elisa A. N. Azevedo ◽  
Clarice N. L. de Morais ◽  
Larissa I. O. de Sousa ◽  
Bruno M. Carvalho ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Virus Infection ◽  
Virus Replication ◽  
Zika Virus ◽  
Mammalian Cells ◽  
Caspase 3 ◽  
Neurological Complications ◽  
Zika Virus Infection

Background: Zika virus is an emerging arbovirus of global importance. ZIKV infection is associated with a range of neurological complications such as the Congenital Zika Syndrome and Guillain Barré Syndrome. Despite the magnitude of recent outbreaks, there is no specific therapy to prevent or to alleviate disease pathology. Objective: To investigate the role of P-MAPA immunomodulator in Zika-infected THP-1 cells. Methods: THP-1 cells were subjected at Zika virus infection (Multiplicity of Infection = 0.5) followed by treatment with P-MAPA for until 96 hours post-infection. After that, the cell death was analyzed by annexin+/ PI+ and caspase 3/ 7+ staining by flow cytometry. In addition, the virus replication and cell proliferation were accessed by RT-qPCR and Ki67 staining, respectively. Results: We demonstrate that P-MAPA in vitro treatment significantly reduces Zika virus-induced cell death and caspase-3/7 activation on THP-1 infected cells, albeit it has no role in virus replication and cell proliferation. Conclusions: Our study reveals that P-MAPA seems to be a satisfactory alternative to inhibits the effects of Zika virus infection in mammalian cells.

Neurological Complications of Congenital Zika Virus Infection

2019 ◽  
Vol 91 ◽  
pp. 3-10 ◽  
Author(s):  
Vinícius de Melo Marques ◽  
Camilla Sousa Santos ◽  
Isabella Godinho Santiago ◽  
Solomar Martins Marques ◽  
Maria das Graças Nunes Brasil ◽  
...  
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Neurological Complications ◽  
Zika Virus Infection

Cardiac involvement in genetic disease

2010 ◽  
pp. 2834-2841
Author(s):  
Thomas A. Traill
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Family History ◽  
Genetic Disease ◽  
Congenital Heart ◽  
Cardiac Involvement ◽  
Atrioventricular Canal ◽  
Marfan's Syndrome ◽  
Atrioventricular Canal Defect ◽  
History Of

Many clinicians find themselves faced, from time to time, with a patient who has a family history of a known disorder, such as Marfan’s syndrome, or who has noncardiac features that suggest a syndrome. Down’s syndrome—25 to 50% have congenital heart disease, most characteristically atrioventricular canal defect....

Zika virus infection in children: epidemiology and clinical manifestations

2017 ◽  
Vol 34 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Marcos Vinicius da Silva Pone ◽  
Sheila Moura Pone ◽  
Andrea Araujo Zin ◽  
Pedro Henrique Barros Mendes ◽  
Mitsue Senra Aibe ◽  
...  
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Clinical Manifestations ◽  
Zika Virus Infection

Seroprevalence of Zika virus in selected regions in Kenya

2019 ◽  
Vol 113 (12) ◽  
pp. 735-739 ◽  
Author(s):  
Bramuel Kisuya ◽  
Moses M Masika ◽  
Esto Bahizire ◽  
Julius O Oyugi
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Healthy Adult ◽  
Neurological Complications ◽  
Previous Exposure ◽  
Limited Data ◽  
Zika Virus Infection ◽  
Human Sera ◽  
Study Population ◽  
The University

Abstract Background The Zika virus pandemic in South America in 2015–2016 and the association of Zika virus infection with neurological complications such as microcephaly in newborns distressed the global community. There is limited data on the prevalence of Zika virus in Kenya despite evidence of its circulation in East Africa. This study aimed at assessing the seroprevalence of Zika virus in selected areas in Kenya. Methods Healthy adult human sera originally collected from Nairobi, Eldoret and Kisumu from 2009 to 2014 and archived at the University of Nairobi laboratories were examined for Zika virus antibodies. An IgG-based ELISA was used to screen 577 sera. Any serum tested positive by ELISA was confirmed for Zika virus infection by plaque reduction neutralization test (PRNT). Results The seroprevalence of Zika virus in the study population was about 0.2 % (1/577) as confirmed by PRNT. Additionally, three sera that were false positive by ELISA for Zika virus were confirmed as positive for dengue virus by PRNT. Conclusion There was evidence of low previous exposure to Zika virus in the study population. Of the three regions in Kenya where sera for this study were obtained, only Kisumu County had one case of previous exposure to Zika virus.

scholarly journals Clinical Manifestations of Zika Virus Infection, Rio de Janeiro, Brazil, 2015

2016 ◽  
Vol 22 (7) ◽  
pp. 1318-1320 ◽  
Author(s):  
José Cerbino-Neto ◽  
Emersom Cicilini Mesquita ◽  
Thiago Moreno L. Souza ◽  
Viviane Parreira ◽  
Bernardo Bastos Wittlin ◽  
...  
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Rio De Janeiro ◽  
Clinical Manifestations ◽  
Zika Virus Infection
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