Optimal Therapy for Chronic Myeloid Leukemia Blast Crisis: Current Concepts

2006 ◽  
Vol 1 (2) ◽  
pp. 87-94
Author(s):  
Constantine S. Tam ◽  
Hagop Kantarjian ◽  
Jorge E. Cortes
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blast Crisis ◽  
Optimal Therapy ◽  
Leukemia Blast

Chronic myeloid leukemia with pure erythroid leukemia blast crisis

2021 ◽  
pp. 1-5
Author(s):  
Jeremy W. Jacobs ◽  
Rahul Ramaswamy ◽  
Vanessa States ◽  
Jennifer Reppucci ◽  
Olalekan O. Oluwole ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blast Crisis ◽  
Leukemia Blast

scholarly journals Aberrant activation of CaMKIIγ accelerates chronic myeloid leukemia blast crisis

Leukemia ◽  
2016 ◽  
Vol 30 (6) ◽  
pp. 1282-1289 ◽  
Author(s):  
Y Gu ◽  
W Zheng ◽  
J Zhang ◽  
X Gan ◽  
X Ma ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blast Crisis ◽  
Leukemia Blast

Epidural myeloid sarcoma as the presenting symptom of chronic myeloid leukemia blast crisis

2020 ◽  
Vol 39 (8) ◽  
pp. 2453-2459
Author(s):  
Maroua Slouma ◽  
Safa Rahmouni ◽  
Rim Dhahri ◽  
Yasmine Khayati ◽  
Samy Zriba ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blast Crisis ◽  
Myeloid Sarcoma ◽  
Leukemia Blast

scholarly journals Circulating endothelial cells are increased in chronic myeloid leukemia blast crisis

2015 ◽  
Vol 48 (6) ◽  
pp. 509-514
Author(s):  
C.R.T. Godoy ◽  
D. Levy ◽  
V. Giampaoli ◽  
D.A.F. Chamone ◽  
S.P. Bydlowski ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blast Crisis ◽  
Circulating Endothelial Cells ◽  
Leukemia Blast

B-lymphoid or myeloid lineage identity of cell lines derived from chronic myeloid leukemia blast crisis

2005 ◽  
Vol 161 (2) ◽  
pp. 187-188
Author(s):  
Bonaventure Ndikung Bejeng Soh ◽  
Florian Klein ◽  
Niklas Feldhahn ◽  
Markus Müschen
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Cell Lines ◽  
Myeloid Leukemia ◽  
Blast Crisis ◽  
Myeloid Lineage ◽  
Leukemia Blast ◽  
B Lymphoid

Coexistence of inversion 16 and the Philadelphia chromosome comprising P190 BCR/ABL in chronic myeloid leukemia blast crisis

2011 ◽  
Vol 93 (6) ◽  
pp. 806-810 ◽  
Author(s):  
Soranobu Ninomiya ◽  
Nobuhiro Kanemura ◽  
Hisashi Tsurumi ◽  
Senji Kasahara ◽  
Takeshi Hara ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blast Crisis ◽  
Philadelphia Chromosome ◽  
Leukemia Blast

scholarly journals Immunophenotyping in Chronic Myeloid Leukemia Blast Crisis: Looking beyond Morphology

2016 ◽  
Vol 50 (4) ◽  
pp. 181-184
Author(s):  
Subhash Varma ◽  
Neelam Varma ◽  
Pankaj Malhotra ◽  
Vikram Narang ◽  
Man US Sachdeva ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blast Crisis ◽  
Chronic Phase ◽  
Common Occurrence ◽  
Treatment Protocols ◽  
Female Ratio ◽  
Leukemia Blast ◽  
Male To Female

ABSTRACT Introduction Patients of chronic myeloid leukemia (CML) eventually transform to blast crisis (BC) after a variable length of chronic phase (CP). With improvement in management protocols, many patients of CML-BC are expected to show remission after initial chemotherapy and a better survival. Hence, it becomes imperative to correctly classify the nature of BC for further course of management. Materials and methods This study retrospectively analyzed cases of CML-BC, over a period of 5 years, with comprehensive immunophenotyping done on flow cytometry. Results Fifteen cases of CML-BC with male-to-female ratio of 3:1 and mean age of 40.2 years were included in the study. Flow cytometry revealed 14 cases of myeloid and one case of lymphoid BC. One case each of megakaryocytic and myelomonocytic lineage were seen among the 14 cases of myeloid BC. Aberrant marker expression was a common occurrence. Myeloperoxidase cytochemical stain had shown positivity only in 3 of the 14 cases of myeloid BC. Conclusion Immunophenotyping is necessary for assigning specific lineage to blasts in patients of CML-BC and thus providing clinically useful information regarding the treatment protocols and prognosis of the patient. How to cite this article Narang V, Sachdeva MUS, Bose P, Varma N, Malhotra P, Varma S. Immunophenotyping in Chronic Myeloid Leukemia Blast Crisis: Looking beyond Morphology. J Postgrad Med Edu Res 2016;50(4):181-184

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