Detection of Mutated K12-ras in Histologically Negative Lymph Nodes as an Indicator of Poor Prognosis in Stage II Colorectal Cancer

2001 ◽  
Vol 1 (2) ◽  
pp. 110-116 ◽  
Author(s):  
Robert T. Belly ◽  
Joseph D. Rosenblatt ◽  
Michele Steinmann ◽  
Jacqueline Toner ◽  
Jianbo Sun ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Nodes ◽  
Poor Prognosis ◽  
Stage Ii ◽  
Stage Ii Colorectal Cancer ◽  
Negative Lymph Nodes

scholarly journals Prognostic Impact of the Number of Examined Lymph Nodes in Stage II Colorectal Adenocarcinoma: A Retrospective Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Purun Lei ◽  
Ying Ruan ◽  
Jianpei Liu ◽  
Qixian Zhang ◽  
Xiao Tang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Stage Ii ◽  
Lymph Node Status ◽  
Stage Migration ◽  
Prognostic Impact ◽  
Disease Specific Survival ◽  
Stage Ii Colorectal Cancer ◽  
Disease Specific

Background. Evaluation of lymph node status is critical in colorectal carcinoma (CRC) treatment. However, as patients with node involvement may be incorrectly classified into earlier stages if the examined lymph node (ELN) number is too small and escape adjuvant therapy, especially for stage II CRC. The aims of this study were to assess the impact of the ELN on the survival of patients with stage II colorectal cancer and to determine the optimal number. Methods. Data from the US Surveillance, Epidemiology, and End Results (SEER) database on stage II resected CRC (1988-2013) were extracted for mathematical modeling as ELN was available since 1988. Relationship between ELN count and stage migration and disease-specific survival was analyzed by using multivariable models. The series of the mean positive LNs, odds ratios (ORs), and hazard ratios (HRs) were fitted with a LOWESS (Locally Weighted Scatterplot Smoothing) smoother, and the structural break points were determined by the Chow test. An independent cohort of cases from 2014 was retrieved for validation in 5-year disease-specific survival (DSS). Results. An increased ELN count was associated with a higher possibility of metastasis LN detection (OR 1.010, CI 1.009-1.011, p<0.001) and better DSS in LN negative patients (OR 0.976, CI 0.975-0.977, p<0.001). The cut-off point analysis showed a threshold ELN count of 21 nodes (HR 0.692, CI 0.667-0.719, p<0.001) and was validated with significantly better DSS in the SEER 2009 cohort CRC (OR 0.657, CI 0.522-0.827, p<0.001). The cut-off value of the ELN count in site-specific surgeries was analyzed as 20 nodes in the right hemicolectomy (HR 0.674, CI 0.638-0.713, p<0.001), 19 nodes in left hemicolectomy (HR 0.691, CI 0.639-0.749, p<0.001), and 20 nodes in rectal resection patients (HR 0.671, CI 0.604-0.746, p<0.001), respectively. Conclusions. A higher number of ELNs are associated with more-accurate node staging and better prognosis in stage II CRCs. We recommend that at least 21 lymph nodes be examined for accurate diagnosis of stage II colorectal cancer.

AC133 expression associated with poor prognosis in stage II colorectal cancer

2013 ◽  
Vol 30 (1) ◽  
Author(s):  
Xiaofang Ying ◽  
Jiangxue Wu ◽  
Xiangqi Meng ◽  
Yufang Zuo ◽  
Qing Xia ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Poor Prognosis ◽  
Stage Ii ◽  
Stage Ii Colorectal Cancer

scholarly journals MAPT promoter CpG island hypermethylation is associated with poor prognosis in patients with stage II colorectal cancer

2019 ◽  
Vol Volume 11 ◽  
pp. 7337-7343 ◽  
Author(s):  
Chuntao Wang ◽  
Yanliang Liu ◽  
Wenyi Guo ◽  
Xu Zhu ◽  
Nita Ahuja ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Poor Prognosis ◽  
Cpg Island ◽  
Stage Ii ◽  
Stage Ii Colorectal Cancer

Size and number of examined lymph nodes impacts outcome in patients with stage II colorectal cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 3507-3507 ◽  
Author(s):  
L. Chirieac ◽  
Y. Suehiro ◽  
A. Niemisto ◽  
I. Shmulevich ◽  
S. Lunagomez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Nodes ◽  
Stage Ii ◽  
Stage Ii Colorectal Cancer

scholarly journals Promoter CpG island methylation of RET predicts poor prognosis in stage II colorectal cancer patients

2014 ◽  
Vol 8 (3) ◽  
pp. 679-688 ◽  
Author(s):  
Muriel X.G. Draht ◽  
Kim M. Smits ◽  
Benjamin Tournier ◽  
Valerie Jooste ◽  
Caroline Chapusot ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Cpg Island ◽  
Stage Ii ◽  
Stage Ii Colorectal Cancer ◽  
Cpg Island Methylation ◽  
Colorectal Cancer Patients
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