Targeting the Ubiquitin—Proteasome Pathway in Breast Cancer

2004 ◽  
Vol 5 (2) ◽  
pp. 148-157 ◽  
Author(s):  
Fatima Cardoso ◽  
Jeffrey S. Ross ◽  
Martine J. Piccart ◽  
Christos Sotiriou ◽  
Virginie Durbecq
Keyword(s):  
Breast Cancer ◽  
Ubiquitin Proteasome Pathway ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway

Targeting the ubiquitin-proteasome pathway in breast cancer

2004 ◽  
Vol 2 (3) ◽  
pp. 63-64
Author(s):  
F Cardoso ◽  
M.J Piccart ◽  
C Sotiriou ◽  
V Durbecq
Keyword(s):  
Breast Cancer ◽  
Ubiquitin Proteasome Pathway ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway

scholarly journals β-glucan from Lentinus edodes inhibits breast cancer progression via the Nur77/HIF-1α axis

2020 ◽  
Vol 40 (12) ◽  
Author(s):  
Xiuru Zhang ◽  
Tingting Li ◽  
Shuwen Liu ◽  
Yiming Xu ◽  
Minjun Meng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Lung Metastases ◽  
Strong Positive Correlation ◽  
Lentinus Edodes ◽  
Small Interference Rna ◽  
Ubiquitin Proteasome Pathway ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway

Abstract Background: β-glucan from Lentinus edodes (LNT) is a plant-derived medicinal fungus possessing significant bioactivities on anti-tumor. Both hypoxia-induced factor-1α (HIF)-1α and Nur77 have been shown to be involved in the development of breast cancer. However, there is yet no proof of Nur77/HIF-1α involvement in the process of LNT-mediated tumor-inhibition effect. Methods: Immunohistochemistry, immunofluorescence and Hematoxylin–Eosin staining were used to investigate tumor growth and metastasis in MMTV-PyMT transgenic mice. Proliferation and metastasis-associated molecules were determined by Western blotting and reverse transcription-quantitative PCR. Hypoxic cellular model was established under the exposure of CoCl2. Small interference RNA was transfected using Lipofectamine reagent. The ubiquitin proteasome pathway was blunted by adding the proteasome inhibitor MG132. Results: LNT inhibited the growth of breast tumors and the development of lung metastases from breast cancer, accompanied by a decreased expression of HIF-1α in the tumor tissues. In in vitro experiments, hypoxia induced the expression of HIF-1α and Nur77 in breast cancer cells, while LNT addition down-regulated HIF-1α expression in an oxygen-free environment, and this process was in a manner of Nur77 dependent. Mechanistically, LNT evoked the down-regulation of HIF-1α involved the Nur77-mediated ubiquitin proteasome pathway. A strong positive correlation between Nur77 and HIF-1α expression in human breast cancer specimens was also confirmed. Conclusion: Therefore, LNT appears to inhibit the progression of breast cancer partly through the Nur77/HIF-1α signaling axis. The findings of the present study may provide a theoretical basis for targeting HIFs in the treatment of breast cancer.

REGγ regulates ERα degradation via ubiquitin–proteasome pathway in breast cancer

2015 ◽  
Vol 456 (1) ◽  
pp. 534-540 ◽  
Author(s):  
Fan Chai ◽  
Yan Liang ◽  
Jiong Bi ◽  
Li Chen ◽  
Fan Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ubiquitin Proteasome Pathway ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway
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