Molecular Determinants of Occult Metastatic Tumor Cells in Bone Marrow

2001 ◽  
Vol 2 (3) ◽  
pp. 222-228 ◽  
Author(s):  
Klaus Pantel ◽  
Stephan Braun
Keyword(s):  
Bone Marrow ◽  
Tumor Cells ◽  
Metastatic Tumor ◽  
Molecular Determinants

Factors regulating the growth of metastatic cancer in bone.

1999 ◽  
pp. 333-347 ◽  
Author(s):  
B F Boyce ◽  
T Yoneda ◽  
T A Guise
Keyword(s):  
Bone Marrow ◽  
Tumor Cells ◽  
Bone Cells ◽  
Vascular Endothelial Cells ◽  
Current Knowledge ◽  
Metastatic Cancer ◽  
Bone Matrix ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Surface Proteins

Metastatic tumor cells can interfere directly with the function of bone cells involved in normal bone remodeling or indirectly by influencing the behavior of hematopoietic, stromal and other cells in bone marrow that interact with bone cells. Recent studies of metastatic cancer have revealed that tumor cells interact closely with vascular endothelial cells, basement membrane and bone marrow stromal cells through cell surface proteins or by releasing factors which affect the function of these cells. Bidirectional interaction between marrow cells and tumor cells can give the latter a selective advantage for growth in bone which can lead to the destruction of or to increased production of bone matrix. Understanding of the mechanisms involved in tumor metastasis and growth in bone has increased in recent years, and in this review we shall describe current knowledge of these mechanisms and of the predilection of certain types of cancers to metastasize to bone, their growth in the bone microenvironment and interactions between them and bone cells. Because metastatic breast cancer has been studied more than any other, we shall focus on it as a representative example, although the general principles apply to other types of cancer and to myeloma.

scholarly journals Mechanisms, Diagnosis and Treatment of Bone Metastases

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2944
Author(s):  
Jozef Ban ◽  
Valerie Fock ◽  
Dave N. T. Aryee ◽  
Heinrich Kovar
Keyword(s):  
Bone Marrow ◽  
Bone Metastases ◽  
Tumor Cells ◽  
Metastatic Tumor ◽  
Disease Outcome ◽  
Bone Marrow Niche ◽  
Therapeutic Implications ◽  
Metastatic Process ◽  
Breast And Prostate Cancer ◽  
Metastatic Sites

Bone and bone marrow are among the most frequent metastatic sites of cancer. The occurrence of bone metastasis is frequently associated with a dismal disease outcome. The prevention and therapy of bone metastases is a priority in the treatment of cancer patients. However, current therapeutic options for patients with bone metastatic disease are limited in efficacy and associated with increased morbidity. Therefore, most current therapies are mainly palliative in nature. A better understanding of the underlying molecular pathways of the bone metastatic process is warranted to develop novel, well-tolerated and more successful treatments for a significant improvement of patients’ quality of life and disease outcome. In this review, we provide comparative mechanistic insights into the bone metastatic process of various solid tumors, including pediatric cancers. We also highlight current and innovative approaches to biologically targeted therapy and immunotherapy. In particular, we discuss the role of the bone marrow microenvironment in the attraction, homing, dormancy and outgrowth of metastatic tumor cells and the ensuing therapeutic implications. Multiple signaling pathways have been described to contribute to metastatic spread to the bone of specific cancer entities, with most knowledge derived from the study of breast and prostate cancer. However, it is likely that similar mechanisms are involved in different types of cancer, including multiple myeloma, primary bone sarcomas and neuroblastoma. The metastatic rate-limiting interaction of tumor cells with the various cellular and noncellular components of the bone-marrow niche provides attractive therapeutic targets, which are already partially exploited by novel promising immunotherapies.

Disseminated tumor cells in bone marrow of breast cancer patients–Comparison of immunocytochemistry and RT-PCR

2006 ◽  
Vol 66 (S 01) ◽  
Author(s):  
T Fehm ◽  
S Becker ◽  
MJ Banys ◽  
G Becker-Pergola ◽  
S Duerr-Stoerzer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Disseminated Tumor Cells ◽  
Breast Cancer Patients ◽  
Rt Pcr
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